| Copper-catalyzed electrophilic carbofunctionalization of alkynes to highly functionalized tetrasubstituted alkenes MG Suero, ED Bayle, BSL Collins, MJ Gaunt Journal of the American Chemical Society 135 (14), 5332-5335, 2013 | 228 | 2013 |
| New approaches for the treatment of Alzheimer’s disease PV Fish, D Steadman, ED Bayle, P Whiting Bioorganic & medicinal chemistry letters 29 (2), 125-133, 2019 | 160 | 2019 |
| Systematic investigation of the permeability of androgen receptor PROTACs DE Scott, TPC Rooney, ED Bayle, T Mirza, HMG Willems, JH Clarke, ... ACS Medicinal Chemistry Letters 11 (8), 1539-1547, 2020 | 52 | 2020 |
| Design of a biased potent small molecule inhibitor of the bromodomain and PHD finger-containing (BRPF) proteins suitable for cellular and in vivo studies N Igoe, ED Bayle, O Fedorov, C Tallant, P Savitsky, C Rogers, DR Owen, ... Journal of medicinal chemistry 60 (2), 668-680, 2017 | 49 | 2017 |
| Selective targeting of bromodomains of the bromodomain-PHD fingers family impairs osteoclast differentiation JC Meier, C Tallant, O Fedorov, H Witwicka, SY Hwang, RG Van Stiphout, ... ACS chemical biology 12 (10), 2619-2630, 2017 | 42 | 2017 |
| Design of a chemical probe for the bromodomain and plant homeodomain finger-containing (BRPF) family of proteins N Igoe, ED Bayle, C Tallant, O Fedorov, JC Meier, P Savitsky, C Rogers, ... Journal of medicinal chemistry 60 (16), 6998-7011, 2017 | 38 | 2017 |
| New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms SS Spurr, ED Bayle, W Yu, F Li, W Tempel, M Vedadi, M Schapira, ... Bioorganic & Medicinal Chemistry Letters 26 (18), 4518-4522, 2016 | 30 | 2016 |
| Carboxylesterase notum is a druggable target to modulate Wnt signaling ED Bayle, F Svensson, BN Atkinson, D Steadman, NJ Willis, ... Journal of medicinal chemistry 64 (8), 4289-4311, 2021 | 25 | 2021 |
| The proteostasis network provides targets for neurodegeneration TM Newton, JA Duce, ED Bayle British journal of pharmacology 176 (18), 3508-3514, 2019 | 18 | 2019 |
| Scaffold-hopping identifies furano [2, 3-d] pyrimidine amides as potent Notum inhibitors BN Atkinson, D Steadman, W Mahy, Y Zhao, J Sipthorp, ED Bayle, ... Bioorganic & Medicinal Chemistry Letters 30 (3), 126751, 2020 | 15 | 2020 |
| An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1, 2-benziodoxol-3-one as a superior electrophilic chlorinating agent NJ Willis, ED Bayle, G Papageorgiou, D Steadman, BN Atkinson, W Mahy, ... Beilstein Journal of Organic Chemistry 15 (1), 2790-2797, 2019 | 11 | 2019 |
| Design of a Potent, selective, and brain-penetrant inhibitor of Wnt-deactivating enzyme notum by optimization of a crystallographic fragment hit NJ Willis, W Mahy, J Sipthorp, Y Zhao, HL Woodward, BN Atkinson, ... Journal of medicinal chemistry 65 (10), 7212-7230, 2022 | 9 | 2022 |
| Structural analysis and development of Notum fragment screening hits Y Zhao, W Mahy, NJ Willis, HL Woodward, D Steadman, ED Bayle, ... ACS Chemical Neuroscience 13 (13), 2060-2077, 2022 | 4 | 2022 |
| Quinolones as inhibitors of class iv bromodomain proteins PV Fish, N Igoe, ED Bayle US Patent App. 15/508,015, 2017 | 4 | 2017 |
| Compounds which are inhibitors of Notum PV Fish, W Mahy, NJ Willis, H Woodward, BN Atkinson, ED Bayle, ... US Patent 11,634,391, 2023 | | 2023 |
| 4-Cyano-2-methoxybenzenesulfonyl Chloride E Bayle Organic Syntheses 94, 198-216, 2017 | | 2017 |
| New strategy fot the synthesis of highly substituted alkenes via copper-catalysed difunctionalization of alkynes MG Suero, E Bayle, BSLF Collins, MJ Gaunt ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 243, 2012 | | 2012 |
| CB2 0AH UK Current Institution TM Newton, JA Duce, ED Bayle | | |
