| Accurate prediction of the relative potencies of members of a series of kinase inhibitors using molecular docking and MM-GBSA scoring PD Lyne, ML Lamb, JC Saeh Journal of medicinal chemistry 49 (16), 4805-4808, 2006 | 690 | 2006 |
| Discovery of Mcl-1-specific inhibitor AZD5991 and preclinical activity in multiple myeloma and acute myeloid leukemia AE Tron, MA Belmonte, A Adam, BM Aquila, LH Boise, E Chiarparin, ... Nature communications 9 (1), 5341, 2018 | 437 | 2018 |
| AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia EK Keeton, K McEachern, KS Dillman, S Palakurthi, Y Cao, MR Grondine, ... Blood, The Journal of the American Society of Hematology 123 (6), 905-913, 2014 | 262 | 2014 |
| A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein JE Penzotti, ML Lamb, E Evensen, PDJ Grootenhuis Journal of medicinal chemistry 45 (9), 1737-1740, 2002 | 223 | 2002 |
| Computational approaches to molecular recognition ML Lamb, WL Jorgensen Current opinion in chemical biology 1 (4), 449-457, 1997 | 189 | 1997 |
| Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain G Akçay, MA Belmonte, B Aquila, C Chuaqui, AW Hird, ML Lamb, ... Nature chemical biology 12 (11), 931-936, 2016 | 187 | 2016 |
| Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1 J Wu, K Mikule, W Wang, N Su, P Petteruti, F Gharahdaghi, E Code, X Zhu, ... ACS chemical biology 8 (10), 2201-2208, 2013 | 160 | 2013 |
| Trk kinase inhibitors as new treatments for cancer and pain T Wang, D Yu, ML Lamb Expert opinion on therapeutic patents 19 (3), 305-319, 2009 | 142 | 2009 |
| Discovery of 5-Chloro-N2-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine (AZD1480) as a Novel Inhibitor of the Jak … S Ioannidis, ML Lamb, T Wang, L Almeida, MH Block, AM Davies, B Peng, ... Journal of medicinal chemistry 54 (1), 262-276, 2011 | 136 | 2011 |
| Performance of 3D-database molecular docking studies into homology models C Oshiro, EK Bradley, J Eksterowicz, E Evensen, ML Lamb, JK Lanctot, ... Journal of medicinal chemistry 47 (3), 764-767, 2004 | 130 | 2004 |
| Prediction of binding affinities for TIBO inhibitors of HIV-1 reverse transcriptase using Monte Carlo simulations in a linear response method RH Smith, WL Jorgensen, J Tirado-Rives, ML Lamb, PAJ Janssen, ... Journal of medicinal chemistry 41 (26), 5272-5286, 1998 | 121 | 1998 |
| Discovery of novel benzylidene-1, 3-thiazolidine-2, 4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases LA Dakin, MH Block, H Chen, E Code, JE Dowling, X Feng, AD Ferguson, ... Bioorganic & medicinal chemistry letters 22 (14), 4599-4604, 2012 | 114 | 2012 |
| Design, docking, and evaluation of multiple libraries against multiple targets ML Lamb, KW Burdick, S Toba, MM Young, AG Skillman, X Zou, ... Proteins: Structure, Function, and Bioinformatics 42 (3), 296-318, 2001 | 100 | 2001 |
| Estimation of the binding affinities of FKBP12 inhibitors using a linear response method ML Lamb, J Tirado-Rives, WL Jorgensen Bioorganic & medicinal chemistry 7 (5), 851-860, 1999 | 94 | 1999 |
| Evaluating free energies of binding and conservation of crystallographic waters using SZMAP AS Bayden, DT Moustakas, D Joseph-McCarthy, ML Lamb Journal of chemical information and modeling 55 (8), 1552-1565, 2015 | 87 | 2015 |
| Identification of 4-aminopyrazolylpyrimidines as potent inhibitors of Trk kinases T Wang, ML Lamb, DA Scott, H Wang, MH Block, PD Lyne, JW Lee, ... Journal of medicinal chemistry 51 (15), 4672-4684, 2008 | 80 | 2008 |
| Structure based design of non-natural peptidic macrocyclic Mcl-1 inhibitors JW Johannes, S Bates, C Beigie, MA Belmonte, J Breen, S Cao, ... ACS medicinal chemistry letters 8 (2), 239-244, 2017 | 71 | 2017 |
| Discovery of AZD4573, a potent and selective inhibitor of CDK9 that enables short duration of target engagement for the treatment of hematological malignancies B Barlaam, R Casella, J Cidado, C Cook, C De Savi, A Dishington, ... Journal of Medicinal Chemistry 63 (24), 15564-15590, 2020 | 64 | 2020 |
| Targeting adenosine A2A receptor antagonism for treatment of cancer M Congreve, GA Brown, A Borodovsky, ML Lamb Expert opinion on drug discovery 13 (11), 997-1003, 2018 | 61 | 2018 |
| Discovery of AZ0108, an orally bioavailable phthalazinone PARP inhibitor that blocks centrosome clustering JW Johannes, L Almeida, K Daly, AD Ferguson, SE Grosskurth, H Guan, ... Bioorganic & medicinal chemistry letters 25 (24), 5743-5747, 2015 | 59 | 2015 |
William L. JorgensenSterling Professor of Chemistry, Yale UniversityVerified email at yale.edu
