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Samir Moussa
Samir Moussa
Associate Director, Innoviva Specialty Therapeutics
Verified email at istx.com
Title
Cited by
Cited by
Year
ETX2514 is a broad-spectrum β-lactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii
TF Durand-Réville, S Guler, J Comita-Prevoir, B Chen, N Bifulco, H Huynh, ...
Nature microbiology 2 (9), 1-10, 2017
2242017
A new platform for ultra-high density Staphylococcus aureus transposon libraries
M Santiago, LM Matano, SH Moussa, MS Gilmore, S Walker, TC Meredith
BMC genomics 16, 1-18, 2015
1022015
Compound-gene interaction mapping reveals distinct roles for Staphylococcus aureus teichoic acids
S Santa Maria JP Jr, Sadaka A, Moussa SH, Brown S, Zhang YJ, Rubin EJ ...
Proc Natl Acad Sci U S A 111 (34), 12510-5, 2014
97*2014
Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent
MD Barnes, V Kumar, CR Bethel, SH Moussa, J O’donnell, JD Rutter, ...
MBio 10 (2), 10.1128/mbio. 00159-19, 2019
84*2019
Rational design of a new antibiotic class for drug-resistant infections
TF Durand-Reville, AA Miller, JP O’Donnell, X Wu, MA Sylvester, S Guler, ...
Nature 597 (7878), 698-702, 2021
832021
Acinetobacter baumannii OmpA Is a Selective Antibiotic Permeant Porin
R Iyer, SH Moussa, TF Durand-Reville, R Tommasi, A Miller
ACS infectious diseases 4 (3), 373-381, 2017
732017
A synthetic lethal approach for compound and target identification in Staphylococcus aureus
L Pasquina, JP Santa Maria Jr, B McKay Wood, SH Moussa, LM Matano, ...
Nature chemical biology 12 (1), 40-45, 2016
702016
Stable micron‐scale holes are a general feature of canonical holins
CG Savva, JS Dewey, SH Moussa, KH To, A Holzenburg, R Young
Molecular microbiology 91 (1), 57-65, 2014
542014
In Vitro Activity of Sulbactam-Durlobactam against Acinetobacter baumannii-calcoaceticus Complex Isolates Collected Globally in 2016 and 2017
SM McLeod, SH Moussa, MA Hackel, AA Miller
Antimicrobial Agents and Chemotherapy 64 (4), 10.1128/aac. 02534-19, 2020
532020
Active Bax and Bak are functional holins
X Pang, SH Moussa, NM Targy, JL Bose, NM George, C Gries, H Lopez, ...
Genes & Development 25 (21), 2278-2290, 2011
502011
Frequency and mechanism of spontaneous resistance to sulbactam combined with the novel β-lactamase inhibitor ETX2514 in clinical isolates of Acinetobacter baumannii
SM McLeod, AB Shapiro, SH Moussa, M Johnstone, RE McLaughlin, ...
Antimicrobial Agents and Chemotherapy 62 (2), 10.1128/aac. 01576-17, 2018
492018
Protein determinants of phage T4 lysis inhibition
SH Moussa, V Kuznetsov, TAT Tran, JC Sacchettini, R Young
Protein Science 21 (4), 571-582, 2012
492012
Durlobactam, a New Diazabicyclooctane β-Lactamase Inhibitor for the Treatment of Acinetobacter Infections in Combination With Sulbactam
AB Shapiro, SH Moussa, SM McLeod, T Durand-Réville, AA Miller
Frontiers in Microbiology 12, 709974, 2021
422021
In vitro characterization of ETX1317, a broad-spectrum β-lactamase inhibitor that restores and enhances β-lactam activity against multi-drug-resistant enterobacteriales …
AA Miller, AB Shapiro, SM McLeod, NM Carter, SH Moussa, R Tommasi, ...
ACS Infectious Diseases 6 (6), 1389-1397, 2020
322020
ETX2514 is a broad-spectrum betalactamase inhibitor for the treatment of drug-resistant Gram-negative bacteria including Acinetobacter baumannii. Nat Microbiol 2: 17104
TF Durand-Réville, S Guler, J Comita-Prevoir, B Chen, N Bifulco, H Huynh, ...
302017
Genetic dissection of T4 lysis
SH Moussa, JL Lawler, R Young
Journal of Bacteriology 196 (12), 2201-2209, 2014
192014
Identification of the sources of< italic> Escherichia coli</italic> in a watershed using carbon-utilization patterns and composite data sets
SH Moussa, R Massengale
Journal of water and health 6 (2), 197-207, 2008
19*2008
Ceftazidime–avibactam resistance mutations V240G, D179Y, and D179Y/T243M in KPC-3 β-lactamase do not alter cefpodoxime–ETX1317 susceptibility
AB Shapiro, SH Moussa, NM Carter, N Gao, AA Miller
ACS Infectious Diseases 7 (1), 79-87, 2020
172020
The structural basis of T4 phage lysis control: DNA as the signal for lysis inhibition
IV Krieger, V Kuznetsov, JY Chang, J Zhang, SH Moussa, RF Young, ...
Journal of molecular biology 432 (16), 4623-4636, 2020
172020
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay
T Furuya, AB Shapiro, J Comita-Prevoir, EJ Kuenstner, J Zhang, SD Ribe, ...
Bioorganic & Medicinal Chemistry 28 (24), 115826, 2020
132020
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