Lars Johannesen
Lars Johannesen
PhD student and Research fellow at FDA and Karolinska Institutet
Verified email at halloffame.dk
Title
Cited by
Cited by
Year
Differentiating Drug‐Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
L Johannesen, J Vicente, JW Mason, C Sanabria, K Waite‐Labott, ...
Clinical Pharmacology & Therapeutics 96 (5), 549-558, 2014
1602014
An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel
WJ Crumb Jr, J Vicente, L Johannesen, DG Strauss
Journal of pharmacological and toxicological methods 81, 251-262, 2016
1262016
Results From the IQ‐CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase
B Darpo, C Benson, C Dota, G Ferber, C Garnett, CL Green, V Jarugula, ...
Clinical Pharmacology & Therapeutics 97 (4), 326-335, 2015
1262015
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias
K Blinova, J Stohlman, J Vicente, D Chan, L Johannesen, ...
Toxicological Sciences 155 (1), 234-247, 2017
1042017
Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
J Vicente, L Johannesen, JW Mason, WJ Crumb, E Pueyo, N Stockbridge, ...
Journal of the American Heart Association 4 (4), e001615, 2015
952015
The IQ‐CSRC Prospective Clinical Phase 1 Study:“Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”
B Darpo, N Sarapa, C Garnett, C Benson, C Dota, G Ferber, V Jarugula, ...
Annals of Noninvasive Electrocardiology 19 (1), 70-81, 2014
942014
Late sodium current block for drug‐induced long QT syndrome: Results from a prospective clinical trial
L Johannesen, J Vicente, JW Mason, C Erato, C Sanabria, K Waite‐Labott, ...
Clinical Pharmacology & Therapeutics 99 (2), 214-223, 2016
872016
Improving the assessment of heart toxicity for all new drugs through translational regulatory science
L Johannesen, J Vicente, RA Gray, L Galeotti, Z Loring, CE Garnett, ...
Clinical Pharmacology & Therapeutics 95 (5), 501-508, 2014
662014
Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study
J Vicente, R Zusterzeel, L Johannesen, J Mason, P Sager, V Patel, ...
Clinical Pharmacology & Therapeutics 103 (1), 54-66, 2018
532018
Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk
DG Strauss, J Vicente, L Johannesen, K Blinova, JW Mason, P Weeke, ...
Circulation 135 (14), 1300-1310, 2017
522017
Automatic ECG quality scoring methodology: mimicking human annotators
L Johannesen, L Galeotti
Physiological Measurement 33 (9), 1479, 2012
522012
Mechanisms of sex and age differences in ventricular repolarization in humans
J Vicente, L Johannesen, L Galeotti, DG Strauss
American heart journal 168 (5), 749-756. e3, 2014
462014
A Comparison of IIR and Wavelet Filtering for Noise Reduction of the ECG
JS Sørensen, L Johannesen, USL Grove, K Lundhus, JP Couderc, C Graff
Computing in Cardiology, 2010, 489-492, 2010
382010
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block
J Vicente, L Johannesen, M Hosseini, JW Mason, PT Sager, E Pueyo, ...
PLOS ONE 11 (12), e0163619, 2016
322016
Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk
L Johannesen, J Vicente, M Hosseini, DG Strauss
PLOS ONE 11 (12), e0166925, 2016
272016
Assessment of ECG quality on an android platform
L Johannesen
Computing in Cardiology 38, 433-436, 2011
272011
Universal correction for QT/RR hysteresis
M Malik, L Johannesen, K Hnatkova, N Stockbridge
Drug safety 39 (6), 577-588, 2016
212016
Assessing ECG signal quality indices to discriminate ECGs with artefacts from pathologically different arrhythmic ECGs
C Daluwatte, L Johannesen, L Galeotti, J Vicente, DG Strauss, CG Scully
Physiological Measurement 37 (8), 1370, 2016
202016
Assessing electrocardiographic data quality and possible replacement of pharmacologic positive control in thorough QT/QTc studies by investigations of drug-free QTc stability
M Malik, J Zhang, L Johannesen, K Hnatkova, C Garnett
Heart Rhythm 8 (11), 1777-1785, 2011
192011
Assessment of Multi‐Ion Channel Block in a Phase I Randomized Study Design: Results of the Ci PA Phase I ECG Biomarker Validation Study
J Vicente, R Zusterzeel, L Johannesen, R Ochoa‐Jimenez, JW Mason, ...
Clinical Pharmacology & Therapeutics 105 (4), 943-953, 2019
182019
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