| Multiplex metabolic pathway engineering using CRISPR/Cas9 in Saccharomyces cerevisiae T Jakočiūnas, I Bonde, M Herrgård, SJ Harrison, M Kristensen, ... Metabolic engineering 28, 213-222, 2015 | 474 | 2015 |
| Site-specific integration in CHO cells mediated by CRISPR/Cas9 and homology-directed DNA repair pathway JS Lee, TB Kallehauge, LE Pedersen, HF Kildegaard Scientific reports 5 (1), 8572, 2015 | 259 | 2015 |
| A consensus genome-scale reconstruction of Chinese hamster ovary cell metabolism H Hefzi, KS Ang, M Hanscho, A Bordbar, D Ruckerbauer, M Lakshmanan, ... Cell systems 3 (5), 434-443. e8, 2016 | 258 | 2016 |
| CRMAGE: CRISPR optimized mage recombineering C Ronda, LE Pedersen, MOA Sommer, AT Nielsen Scientific reports 6 (1), 19452, 2016 | 252 | 2016 |
| Accelerating genome editing in CHO cells using CRISPR Cas9 and CRISPy, a web‐based target finding tool C Ronda, LE Pedersen, HG Hansen, TB Kallehauge, MJ Betenbaugh, ... Biotechnology and bioengineering 111 (8), 1604-1616, 2014 | 236 | 2014 |
| CRISPy-web: an online resource to design sgRNAs for CRISPR applications K Blin, LE Pedersen, T Weber, SY Lee Synthetic and Systems Biotechnology 1 (2), 118-121, 2016 | 182 | 2016 |
| One‐step generation of triple knockout CHO cell lines using CRISPR/Cas9 and fluorescent enrichment LM Grav, JS Lee, S Gerling, TB Kallehauge, AH Hansen, S Kol, GM Lee, ... Biotechnology journal 10 (9), 1446-1456, 2015 | 164 | 2015 |
| Multiplex secretome engineering enhances recombinant protein production and purity S Kol, D Ley, T Wulff, M Decker, J Arnsdorf, S Schoffelen, AH Hansen, ... Nature communications 11 (1), 1908, 2020 | 104 | 2020 |
| Accelerated homology‐directed targeted integration of transgenes in Chinese hamster ovary cells via CRISPR/Cas9 and fluorescent enrichment JS Lee, LM Grav, LE Pedersen, GM Lee, HF Kildegaard Biotechnology and bioengineering 113 (11), 2518-2523, 2016 | 86 | 2016 |
| CasPER, a method for directed evolution in genomic contexts using mutagenesis and CRISPR/Cas9 T Jakočiūnas, LE Pedersen, AV Lis, MK Jensen, JD Keasling Metabolic engineering 48, 288-296, 2018 | 83 | 2018 |
| Ribosome profiling-guided depletion of an mRNA increases cell growth rate and protein secretion TB Kallehauge, S Li, LE Pedersen, TK Ha, D Ley, MR Andersen, ... Scientific reports 7 (1), 40388, 2017 | 67 | 2017 |
| Comprehensive analysis of genomic safe harbors as target sites for stable expression of the heterologous gene in HEK293 cells S Shin, SH Kim, SW Shin, LM Grav, LE Pedersen, JS Lee, GM Lee ACS Synthetic Biology 9 (6), 1263-1269, 2020 | 46 | 2020 |
| Awakening dormant glycosyltransferases in CHO cells with CRISPRa KJC Karottki, H Hefzi, K Xiong, I Shamie, AH Hansen, S Li, LE Pedersen, ... Biotechnology and bioengineering 117 (2), 593-598, 2020 | 43 | 2020 |
| Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals RM Lennen, HG Lim, K Jensen, ET Mohammed, PV Phaneuf, MH Noh, ... Metabolic Engineering 76, 179-192, 2023 | 42 | 2023 |
| Genome-wide CRISPRi-based identification of targets for decoupling growth from production S Li, CB Jendresen, J Landberg, LE Pedersen, N Sonnenschein, ... ACS Synthetic Biology 9 (5), 1030-1040, 2020 | 42 | 2020 |
| Elucidation of the CHO super-ome (CHO-SO) by proteoinformatics A Kumar, D Baycin-Hizal, D Wolozny, LE Pedersen, NE Lewis, K Heffner, ... Journal of proteome research 14 (11), 4687-4703, 2015 | 42 | 2015 |
| Regulation of cell proliferation and cell density by the inorganic phosphate transporter PiT1 K Byskov, N Jensen, IB Kongsfelt, M Wielsøe, LE Pedersen, C Haldrup, ... Cell division 7, 1-16, 2012 | 39 | 2012 |
| Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion D Ley, S Pereira, LE Pedersen, J Arnsdorf, H Hefzi, AM Davy, TK Ha, ... Metabolic Engineering 56, 120-129, 2019 | 36 | 2019 |
| An optimized genome-wide, virus-free CRISPR screen for mammalian cells K Xiong, KJ la Cour Karottki, H Hefzi, S Li, LM Grav, S Li, P Spahn, JS Lee, ... Cell Reports Methods 1 (4), 2021 | 29 | 2021 |
| A dual-reporter system for investigating and optimizing protein translation and folding in E. coli A Zutz, L Hamborg, LE Pedersen, MM Kassem, E Papaleo, A Koza, ... Nature Communications 12 (1), 6093, 2021 | 27 | 2021 |
Gyun Min LeeProfessor of Biological Sciences, KAISTVerified email at kaist.ac.kr
