Telomerase gene therapy in adult and old mice delays aging and increases longevity without increasing cancer B Bernardes de Jesus, E Vera, K Schneeberger, AM Tejera, E Ayuso, ... EMBO molecular medicine 4 (8), 691-704, 2012 | 614 | 2012 |
High AAV vector purity results in serotype-and tissue-independent enhancement of transduction efficiency E Ayuso, F Mingozzi, J Montane, X Leon, XM Anguela, V Haurigot, ... Gene therapy 17 (4), 503-510, 2010 | 337 | 2010 |
Whole body correction of mucopolysaccharidosis IIIA by intracerebrospinal fluid gene therapy V Haurigot, S Marcó, A Ribera, M Garcia, A Ruzo, P Villacampa, E Ayuso, ... The Journal of clinical investigation 123 (8), 3254-3271, 2013 | 241 | 2013 |
β cell expression of IGF-I leads to recovery from type 1 diabetes M George, E Ayuso, A Casellas, C Costa, JC Devedjian, F Bosch The Journal of clinical investigation 109 (9), 1153-1163, 2002 | 230 | 2002 |
Increased ocular levels of IGF-1 in transgenic mice lead to diabetes-like eye disease J Ruberte, E Ayuso, M Navarro, A Carretero, V Nacher, V Haurigot, ... The Journal of clinical investigation 113 (8), 1149-1157, 2004 | 225 | 2004 |
Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats YCL Tung, E Ayuso, X Shan, F Bosch, S O'Rahilly, AP Coll, GSH Yeo PloS one 5 (1), e8771, 2010 | 224 | 2010 |
Pharmacology of recombinant adeno-associated virus production M Penaud-Budloo, A François, N Clément, E Ayuso Molecular therapy Methods & clinical development 8, 166-180, 2018 | 173 | 2018 |
Production, purification and characterization of adeno-associated vectors E Ayuso, F Mingozzi, F Bosch Current gene therapy 10 (6), 423-436, 2010 | 169 | 2010 |
Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material M Lock, S McGorray, A Auricchio, E Ayuso, EJ Beecham, V Blouin-Tavel, ... Mary Ann Liebert, Inc. 140 Huguenot Street, 3rd Floor New Rochelle, NY 10801 USA, 2010 | 161 | 2010 |
Telomerase expression confers cardioprotection in the adult mouse heart after acute myocardial infarction C Bär, BB De Jesus, R Serrano, A Tejera, E Ayuso, V Jimenez, ... Nature communications 5 (1), 5863, 2014 | 155 | 2014 |
Correction of pathological accumulation of glycosaminoglycans in central nervous system and peripheral tissues of MPSIIIA mice through systemic AAV9 gene transfer A Ruzo, S Marcó, M García, P Villacampa, A Ribera, E Ayuso, L Maggioni, ... Human gene therapy 23 (12), 1237-1246, 2012 | 136 | 2012 |
Practical utilization of recombinant AAV vector reference standards: focus on vector genomes titration by free ITR qPCR S d'Costa, V Blouin, F Broucque, M Penaud-Budloo, A Fçranois, IC Perez, ... Molecular Therapy Methods & Clinical Development 3, 2016 | 120 | 2016 |
LRH-1–dependent glucose sensing determines intermediary metabolism in liver MH Oosterveer, C Mataki, H Yamamoto, T Harach, N Moullan, ... The Journal of clinical investigation 122 (8), 2817-2826, 2012 | 120 | 2012 |
Treatment of diabetes and long-term survival after insulin and glucokinase gene therapy D Callejas, CJ Mann, E Ayuso, R Lage, I Grifoll, C Roca, A Andaluz, ... Diabetes 62 (5), 1718-1729, 2013 | 107 | 2013 |
Manufacturing and characterization of a recombinant adeno-associated virus type 8 reference standard material E Ayuso, V Blouin, M Lock, S McGorray, X Leon, MR Alvira, A Auricchio, ... Human gene therapy 25 (11), 977-987, 2014 | 94 | 2014 |
Hypothalamic loss of Snord116 recapitulates the hyperphagia of Prader-Willi syndrome J Polex-Wolf, BYH Lam, R Larder, J Tadross, D Rimmington, F Bosch, ... The Journal of clinical investigation 128 (3), 960-969, 2018 | 93 | 2018 |
Increased intraocular insulin-like growth factor-I triggers blood-retinal barrier breakdown V Haurigot, P Villacampa, A Ribera, C Llombart, A Bosch, V Nacher, ... Journal of biological chemistry 284 (34), 22961-22969, 2009 | 91 | 2009 |
Inducible adeno-associated virus vectors promote functional angiogenesis in adult organisms via regulated vascular endothelial growth factor expression S Tafuro, E Ayuso, S Zacchigna, L Zentilin, S Moimas, F Dore, M Giacca Cardiovascular research 83 (4), 663-671, 2009 | 88 | 2009 |
Vascular endothelial growth factor–mediated islet hypervascularization and inflammation contribute to progressive reduction of β-cell mass J Agudo, E Ayuso, V Jimenez, A Casellas, C Mallol, A Salavert, S Tafuro, ... Diabetes 61 (11), 2851-2861, 2012 | 85 | 2012 |
Phagocytosis-shielded lentiviral vectors improve liver gene therapy in nonhuman primates M Milani, A Annoni, F Moalli, T Liu, D Cesana, A Calabria, S Bartolaccini, ... Science translational medicine 11 (493), eaav7325, 2019 | 79 | 2019 |