Telomeric DNA damage is irreparable and causes persistent DNA-damage-response activation M Fumagalli, F Rossiello, M Clerici, S Barozzi, D Cittaro, JM Kaplunov, ... Nature cell biology 14 (4), 355-365, 2012 | 888 | 2012 |
A central role for DNA replication forks in checkpoint activation and response JA Tercero, MP Longhese, JFX Diffley Molecular cell 11 (5), 1323-1336, 2003 | 480 | 2003 |
The checkpoint protein Ddc2, functionally related to S. pombe Rad26, interacts with Mec1 and is regulated by Mec1-dependent phosphorylation in budding yeast V Paciotti, M Clerici, G Lucchini, MP Longhese Genes & development 14 (16), 2046-2059, 2000 | 344 | 2000 |
The Saccharomyces cerevisiae Sae2 protein promotes resection and bridging of double strand break ends M Clerici, D Mantiero, G Lucchini, MP Longhese Journal of Biological Chemistry 280 (46), 38631-38638, 2005 | 255 | 2005 |
DNA damage response at functional and dysfunctional telomeres MP Longhese Genes & development 22 (2), 125-140, 2008 | 243 | 2008 |
DNA damage checkpoint in budding yeast MP Longhese, M Foiani, M Muzi-Falconi, G Lucchini, P Plevani The EMBO journal 17 (19), 5525-5528, 1998 | 211 | 1998 |
The Yku70–Yku80 complex contributes to regulate double‐strand break processing and checkpoint activation during the cell cycle M Clerici, D Mantiero, I Guerini, G Lucchini, MP Longhese EMBO reports 9 (8), 810-818, 2008 | 203 | 2008 |
RPA regulates telomerase action by providing Est1p access to chromosome ends V Schramke, P Luciano, V Brevet, S Guillot, Y Corda, MP Longhese, ... Nature genetics 36 (1), 46-54, 2004 | 189 | 2004 |
Replication factor A is required in vivo for DNA replication, repair, and recombination MP Longhese, P Plevani, G Lucchini Molecular and cellular biology 14 (12), 7884-7890, 1994 | 177 | 1994 |
The Saccharomyces cerevisiae Sae2 protein negatively regulates DNA damage checkpoint signalling M Clerici, D Mantiero, G Lucchini, MP Longhese EMBO reports 7 (2), 212-218, 2006 | 175 | 2006 |
Mec1p is essential for phosphorylation of the yeast DNA damage checkpoint protein Ddc1p, which physically interacts with Mec3p V Paciotti, G Lucchini, P Plevani, MP Longhese The EMBO journal 17 (14), 4199-4209, 1998 | 169 | 1998 |
Multiple pathways regulate 3′ overhang generation at S. cerevisiae telomeres D Bonetti, M Martina, M Clerici, G Lucchini, MP Longhese Molecular cell 35 (1), 70-81, 2009 | 167 | 2009 |
The novel DNA damage checkpoint protein ddc1p is phosphorylated periodically during the cell cycle and in response to DNA damage in budding yeast MP Longhese, V Paciotti, R Fraschini, R Zaccarini, P Plevani, G Lucchini The EMBO Journal, 1997 | 167 | 1997 |
The functions of budding yeast Sae2 in the DNA damage response require Mec1-and Tel1-dependent phosphorylation E Baroni, V Viscardi, H Cartagena-Lirola, G Lucchini, MP Longhese Molecular and cellular biology, 2004 | 154 | 2004 |
Mechanisms and regulation of DNA end resection MP Longhese, D Bonetti, N Manfrini, M Clerici The EMBO journal 29 (17), 2864-2874, 2010 | 150 | 2010 |
Dual role for Saccharomyces cerevisiae Tel1 in the checkpoint response to double‐strand breaks D Mantiero, M Clerici, G Lucchini, MP Longhese EMBO reports 8 (4), 380-387, 2007 | 149 | 2007 |
Irreparable telomeric DNA damage and persistent DDR signalling as a shared causative mechanism of cellular senescence and ageing F Rossiello, U Herbig, MP Longhese, M Fumagalli, FA di Fagagna Current opinion in genetics & development 26, 89-95, 2014 | 148 | 2014 |
Characterization of mec1 kinase-deficient mutants and of new hypomorphic mec1 alleles impairing subsets of the DNA damage response pathway V Paciotti, M Clerici, M Scotti, G Lucchini, MP Longhese Molecular and cellular biology, 2001 | 143 | 2001 |
Interplays between ATM/Tel1 and ATR/Mec1 in sensing and signaling DNA double-strand breaks E Gobbini, D Cesena, A Galbiati, A Lockhart, MP Longhese DNA repair 12 (10), 791-799, 2013 | 134 | 2013 |
Physical and functional interactions between nucleotide excision repair and DNA damage checkpoint M Giannattasio, F Lazzaro, MP Longhese, P Plevani, M Muzi‐Falconi The EMBO Journal 23 (2), 429-438, 2004 | 131 | 2004 |