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Zhen Wang
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Human DNMT1 transition state structure
Q Du, Z Wang, VL Schramm
Proceedings of the National Academy of Sciences 113 (11), 2916-2921, 2016
752016
Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: beyond promoting vibrations
Z Wang, P Singh, CM Czekster, A Kohen, VL Schramm
Journal of the American Chemical Society 136 (23), 8333-8341, 2014
722014
A remote mutation affects the hydride transfer by disrupting concerted protein motions in thymidylate synthase
Z Wang, T Abeysinghe, JS Finer-Moore, RM Stroud, A Kohen
Journal of the American Chemical Society 134 (42), 17722-17730, 2012
622012
Thymidylate synthase catalyzed H-transfers: Two chapters in one tale
Z Wang, A Kohen
Journal of the American Chemical Society 132 (28), 9820-9825, 2010
502010
Hydride Transfer in DHFR by Transition Path Sampling, Kinetic Isotope Effects and Heavy Enzyme Studies
Z Wang, D Antoniou, SD Schwartz, VL Schramm
Biochemistry 55 (1), 157–166, 2016
362016
Mg2+ Binds to the Surface of Thymidylate Synthase and Affects Hydride Transfer at the Interior Active Site
Z Wang, PJ Sapienza, T Abeysinghe, C Luzum, AL Lee, JS Finer-Moore, ...
Journal of the American Chemical Society 135 (20), 7583-7592, 2013
312013
QM/MM calculations suggest a novel intermediate following the proton abstraction catalyzed by thymidylate synthase
Z Wang, S Ferrer, V Moliner, A Kohen
Biochemistry 52 (13), 2348-2358, 2013
312013
Triple isotope effects support concerted hydride and proton transfer and promoting vibrations in human heart lactate dehydrogenase
Z Wang, EP Chang, VL Schramm
Journal of the American Chemical Society 138 (45), 15004-15010, 2016
272016
Experimental and theoretical studies of enzyme-catalyzed hydrogen-transfer reactions
Z Wang, D Roston, A Kohen
Advances in protein chemistry and structural biology 87, 155-180, 2012
272012
Oxidase activity of a flavin‐dependent thymidylate synthase
Z Wang, A Chernyshev, EM Koehn, TD Manuel, SA Lesley, A Kohen
The FEBS journal 276 (10), 2801-2810, 2009
272009
Kinetic isotope effects in enzymes
A Kohen, D Roston, V Stojković, Z Wang
Encyclopedia of Analytical Chemistry: Applications, Theory and Instrumentation, 2006
72006
Chemoenzymatic Synthesis of Ubiquitous Biological Redox Cofactors
P Singh, Q Guo, A Kohen
Synlett 28 (10), 1151-1159, 2017
62017
Structural and Mechanistic Enzymology: Bringing together Experiments and Computing
Z Wang, D Roston, A Kohen
Elsevier Inc: Oxford, 2012
62012
Encyclopedia of Analytical Chemistry. Meyers, RA., editor. Vol. S1–S3
A Kohen, D Roston, V Stojkoviæ, Z Wang
John Wiley & Sons, Ltd, 2011
52011
Preserved Hydride Transfer Mechanism in Evolutionary Divergent Thymidylate Synthases
A Abeysinghe, Thelma, Hong, Baoyu, Wang, Zhen, Kohen
Current Topics in Biochem. Res., 2016
42016
Catalytic mechanisms of thymidylate synthases: bringing experiments and computations together
Z Wang
The University of Iowa, 2012
2012
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Artikler 1–16