|IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress|
AG Lerner, JP Upton, PVK Praveen, R Ghosh, Y Nakagawa, A Igbaria, ...
Cell metabolism 16 (2), 250-264, 2012
|Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells|
SG Fonseca, S Ishigaki, CM Oslowski, S Lu, KL Lipson, R Ghosh, ...
The Journal of clinical investigation 120 (3), 744-755, 2010
|Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress|
R Ghosh, L Wang, ES Wang, BGK Perera, A Igbaria, S Morita, K Prado, ...
Cell 158 (3), 534-548, 2014
|Transcriptional regulation of VEGF-A by the unfolded protein response pathway|
R Ghosh, KL Lipson, KE Sargent, AM Mercurio, JS Hunt, D Ron, F Urano
PloS one 5 (3), e9575, 2010
|The role of IRE1α in the degradation of insulin mRNA in pancreatic β-cells|
KL Lipson, R Ghosh, F Urano
PloS one 3 (2), e1648, 2008
|The IRE1α–XBP1 pathway is essential for osteoblast differentiation through promoting transcription of Osterix|
T Tohmonda, Y Miyauchi, R Ghosh, M Yoda, S Uchikawa, J Takito, ...
EMBO reports 12 (5), 451-457, 2011
|Targeting ABL-IRE1α signaling spares ER-stressed pancreatic β cells to reverse autoimmune diabetes|
S Morita, SA Villalta, HC Feldman, AC Register, W Rosenthal, ...
Cell metabolism 25 (4), 883-897. e8, 2017
|Small molecule inhibition of IRE1α kinase/RNase has anti-fibrotic effects in the lung|
M Thamsen, R Ghosh, VC Auyeung, A Brumwell, HA Chapman, ...
PLoS One 14 (1), e0209824, 2019
|Endoplasmic reticulum stress, degeneration of pancreatic islet β-cells, and therapeutic modulation of the unfolded protein response in diabetes.|
R Ghosh, K Colon-Negron, FR Papa
Molecular Metabolism 27, 560-568, 2019
|Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival|
PC Moore, JY Qi, M Thamsen, R Ghosh, J Peng, MJ Gliedt, ...
Cancer Research 79 (24), 6190-6203, 2019
|Combined modulation of ire1|
DJ Maly, BJ Backes, SA Oakes, FR Papa, R Ghosh, L Wang
US Patent App. 15/387,463, 2017
|Inhibition Of IRE1±Activity Attenuates ER Stress-Induced Pulmonary Fibrosis|
R Ghosh, MM Giacomini, BJ Backes, D Sheppard, SA Oakes, FR Papa
C18. EMERGING PATHWAYS AND SECONDARY HITS IN PULMONARY FIBROSIS, A3923-A3923, 2012