Antibody engineering for the analysis of affinity maturation of an anti‐hapten response. D Allen, T Simon, F Sablitzky, K Rajewsky, A Cumano The EMBO journal 7 (7), 1995-2001, 1988 | 343 | 1988 |
In vitro to in vivo extrapolation for high throughput prioritization and decision making SM Bell, X Chang, JF Wambaugh, DG Allen, M Bartels, KLR Brouwer, ... Toxicology in vitro 47, 213-227, 2018 | 204 | 2018 |
Development of a neurotoxic equivalence scheme of relative potency for assessing the risk of PCB mixtures T Simon, JK Britt, RC James Regulatory Toxicology and Pharmacology 48 (2), 148-170, 2007 | 121 | 2007 |
Proposing a scientific confidence framework to help support the application of adverse outcome pathways for regulatory purposes G Patlewicz, TW Simon, JC Rowlands, RA Budinsky, RA Becker Regulatory Toxicology and Pharmacology 71 (3), 463-477, 2015 | 113 | 2015 |
Mode of action and dose–response framework analysis for receptor-mediated toxicity: The aryl hydrocarbon receptor as a case study RA Budinsky, D Schrenk, T Simon, M Van den Berg, JF Reichard, ... Critical reviews in toxicology 44 (1), 83-119, 2014 | 84 | 2014 |
The use of mode of action information in risk assessment: Quantitative key events/dose-response framework for modeling the dose-response for key events TW Simon, SS Simons Jr, RJ Preston, AR Boobis, SM Cohen, NG Doerrer, ... Critical reviews in toxicology 44 (sup3), 17-43, 2014 | 65 | 2014 |
Modulatory effects of FMRF-NH2 on outward currents and oscillatory activity in heart interneurons of the medicinal leech TW Simon, CA Opdyke, RL Calabrese Journal of Neuroscience 12 (2), 525-537, 1992 | 62 | 1992 |
Evidence-based toxicology for the 21st century: opportunities and challenges ML Stephens, M Andersen, RA Becker, K Betts, K Boekelheide, E Carney, ... ALTEX-Alternatives to animal experimentation 30 (1), 74-103, 2013 | 56 | 2013 |
An exposure: activity profiling method for interpreting high-throughput screening data for estrogenic activity—Proof of concept RA Becker, KP Friedman, TW Simon, MS Marty, G Patlewicz, ... Regulatory Toxicology and Pharmacology 71 (3), 398-408, 2015 | 51 | 2015 |
Light-evoked walking in crayfish: Behavioral and neuronal responses triggered TW Simon, DH Edwards J Comp Physiol A 166, 745-755, 1990 | 50 | 1990 |
The adverse outcome pathway for rodent liver tumor promotion by sustained activation of the aryl hydrocarbon receptor RA Becker, G Patlewicz, TW Simon, JC Rowlands, RA Budinsky Regulatory Toxicology and Pharmacology 73 (1), 172-190, 2015 | 49 | 2015 |
Human and Rat Primary Hepatocyte CYP1A1 and 1A2 Induction with 2,3,7,8-Tetrachlorodibenzo-p-dioxin, 2,3,7,8-Tetrachlorodibenzofuran, and 2,3,4,7,8 … RA Budinsky, EL LeCluyse, SS Ferguson, JC Rowlands, T Simon Toxicological Sciences 118 (1), 224-235, 2010 | 46 | 2010 |
How well can carcinogenicity be predicted by high throughput “characteristics of carcinogens” mechanistic data? RA Becker, DA Dreier, MK Manibusan, LAT Cox, TW Simon, JS Bus Regulatory Toxicology and Pharmacology 90, 185-196, 2017 | 45 | 2017 |
Use and validation of HT/HC assays to support 21st century toxicity evaluations G Patlewicz, T Simon, K Goyak, RD Phillips, JC Rowlands, SD Seidel, ... Regulatory Toxicology and Pharmacology 65 (2), 259-268, 2013 | 45 | 2013 |
Providing context for phosphatidylethanol as a biomarker of alcohol consumption with a pharmacokinetic model TW Simon Regulatory Toxicology and Pharmacology 94, 163-171, 2018 | 42 | 2018 |
Two-dimensional Monte Carlo simulation and beyond: a comparison of several probabilistic risk assessment methods applied to a superfund site TW Simon Human and Ecological Risk Assessment: An International Journal 5 (4), 823-843, 1999 | 42 | 1999 |
Utilizing threshold of toxicological concern (TTC) with high throughput exposure predictions (HTE) as a risk-based prioritization approach for thousands of chemicals G Patlewicz, JF Wambaugh, SP Felter, TW Simon, RA Becker Computational Toxicology 7, 58-67, 2018 | 40 | 2018 |
Modulation of high-threshold transmission between heart interneurons of the medicinal leech by FMRF-NH2 TW Simon, J Schmidt, RL Calabrese Journal of neurophysiology 71 (2), 454-466, 1994 | 36 | 1994 |
Estimates of Cancer Potency of 2,3,7,8-Tetrachlorodibenzo(p)dioxin Using Linear and Nonlinear Dose-Response Modeling and Toxicokinetics T Simon, LL Aylward, CR Kirman, JC Rowlands, RA Budinsky Toxicological sciences 112 (2), 490-506, 2009 | 35 | 2009 |
Approaches for describing and communicating overall uncertainty in toxicity characterizations: US Environmental Protection Agency's Integrated Risk Information System (IRIS) as … NB Beck, RA Becker, N Erraguntla, WH Farland, RL Grant, G Gray, ... Environment international 89, 110-128, 2016 | 34 | 2016 |