| Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis. DW Cleveland, SG Fischer, MW Kirschner, UK Laemmli Journal of Biological Chemistry 252 (3), 1102-1106, 1977 | 6433 | 1977 |
| Number and evolutionary conservation of α-and β-tubulin and cytoplasmic β-and γ-actin genes using specific cloned cDNA probes DW Cleveland, MA Lopata, RJ MacDonald, NJ Cowan, WJ Rutter, ... Cell 20 (1), 95-105, 1980 | 2007 | 1980 |
| Onset and progression in inherited ALS determined by motor neurons and microglia S Boillée, K Yamanaka, CS Lobsiger, NG Copeland, NA Jenkins, ... Science 312 (5778), 1389-1392, 2006 | 1843 | 2006 |
| Decoding ALS: from genes to mechanism JP Taylor, RH Brown Jr, DW Cleveland Nature 539 (7628), 197-206, 2016 | 1752 | 2016 |
| ALS: a disease of motor neurons and their nonneuronal neighbors S Boillée, CV Velde, DW Cleveland Neuron 52 (1), 39-59, 2006 | 1732 | 2006 |
| An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria PC Wong, CA Pardo, DR Borchelt, MK Lee, NG Copeland, NA Jenkins, ... Neuron 14 (6), 1105-1116, 1995 | 1731 | 1995 |
| Converging mechanisms in ALS and FTD: disrupted RNA and protein homeostasis SC Ling, M Polymenidou, DW Cleveland Neuron 79 (3), 416-438, 2013 | 1664 | 2013 |
| From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS DW Cleveland, JD Rothstein Nature reviews neuroscience 2 (11), 806-819, 2001 | 1656 | 2001 |
| Unraveling the mechanisms involved in motor neuron degeneration in ALS LI Bruijn, TM Miller, DW Cleveland Annu. Rev. Neurosci. 27, 723-749, 2004 | 1650 | 2004 |
| ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions LI Bruijn, MW Becher, MK Lee, KL Anderson, NA Jenkins, NG Copeland, ... Neuron 18 (2), 327-338, 1997 | 1592 | 1997 |
| Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1 LI Bruijn, MK Houseweart, S Kato, KL Anderson, SD Anderson, E Ohama, ... Science 281 (5384), 1851-1854, 1998 | 1524 | 1998 |
| On the road to cancer: aneuploidy and the mitotic checkpoint GJPL Kops, BAA Weaver, DW Cleveland Nature Reviews Cancer 5 (10), 773-785, 2005 | 1500 | 2005 |
| Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice AM Clement, MD Nguyen, EA Roberts, ML Garcia, S Boillee, M Rule, ... science 302 (5642), 113-117, 2003 | 1341 | 2003 |
| Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43 M Polymenidou, C Lagier-Tourenne, KR Hutt, SC Huelga, J Moran, ... Nature neuroscience 14 (4), 459-468, 2011 | 1290 | 2011 |
| A structural scaffolding of intermediate filaments in health and disease E Fuchs, DW Cleveland Science 279 (5350), 514-519, 1998 | 1268 | 1998 |
| Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis K Yamanaka, SJ Chun, S Boillee, N Fujimori-Tonou, H Yamashita, ... Nature neuroscience 11 (3), 251-253, 2008 | 1259 | 2008 |
| Centromeres and kinetochores: from epigenetics to mitotic checkpoint signaling DW Cleveland, Y Mao, KF Sullivan Cell 112 (4), 407-421, 2003 | 1209 | 2003 |
| Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin DW Cleveland, SY Hwo, MW Kirschner Journal of molecular biology 116 (2), 207-225, 1977 | 1179 | 1977 |
| Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond H Ilieva, M Polymenidou, DW Cleveland Journal of Cell Biology 187 (6), 761-772, 2009 | 1164 | 2009 |
| TDP-43 and FUS/TLS: emerging roles in RNA processing and neurodegeneration C Lagier-Tourenne, M Polymenidou, DW Cleveland Human molecular genetics 19 (R1), R46-R64, 2010 | 1127 | 2010 |
Marc KirschnerProfessor of Systems Biology, Harvard Medical SchoolVerified email at hms.harvard.edu
