Julia Shifman
Julia Shifman
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Transfer-PCR (TPCR): a highway for DNA cloning and protein engineering
A Erijman, A Dantes, R Bernheim, JM Shifman, Y Peleg
Journal of structural biology 175 (2), 171-177, 2011
Heme redox potential control in de novo designed four-α-helix bundle proteins
JM Shifman, BR Gibney, RE Sharp, PL Dutton
Biochemistry 39 (48), 14813-14821, 2000
Computational design of an integrin I domain stabilized in the open high affinity conformation
M Shimaoka, JM Shifman, H Jing, J Takagi, SL Mayo, TA Springer
Nature structural biology 7 (8), 674-678, 2000
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums
JM Shifman, MH Choi, S Mihalas, SL Mayo, MB Kennedy
Proceedings of the National Academy of Sciences 103 (38), 13968-13973, 2006
Modulating calmodulin binding specificity through computational protein design
JM Shifman, SL Mayo
Journal of molecular biology 323 (3), 417-423, 2002
Exploring the origins of binding specificity through the computational redesign of calmodulin
JM Shifman, SL Mayo
Proceedings of the National Academy of Sciences 100 (23), 13274-13279, 2003
How structure defines affinity in protein-protein interactions
A Erijman, E Rosenthal, JM Shifman
PLOS one 9 (10), e110085, 2014
Functionalized de novo designed proteins: mechanism of proton coupling to oxidation/reduction in heme protein maquettes
JM Shifman, CC Moser, WA Kalsbeck, DF Bocian, PL Dutton
Biochemistry 37 (47), 16815-16827, 1998
What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf
D Filchtinski, O Sharabi, A Rüppel, IR Vetter, C Herrmann, JM Shifman
Journal of molecular biology 399 (3), 422-435, 2010
Development of high affinity and high specificity inhibitors of matrix metalloproteinase 14 through computational design and directed evolution
V Arkadash, G Yosef, J Shirian, I Cohen, Y Horev, M Grossman, I Sagi, ...
Journal of Biological Chemistry 292 (8), 3481-3495, 2017
Tradeoff between stability and multispecificity in the design of promiscuous proteins
M Fromer, JM Shifman
PLoS computational biology 5 (12), e1000627, 2009
Computational design of calmodulin mutants with up to 900-fold increase in binding specificity
E Yosef, R Politi, MH Choi, JM Shifman
Journal of molecular biology 385 (5), 1470-1480, 2009
Multispecific recognition: mechanism, evolution, and design
A Erijman, Y Aizner, JM Shifman
Biochemistry 50 (5), 602-611, 2011
Dead‐end elimination for multistate protein design
C Yanover, M Fromer, JM Shifman
Journal of computational chemistry 28 (13), 2122-2129, 2007
Protein engineering by combined computational and in vitro evolution approaches
L Rosenfeld, M Heyne, JM Shifman, N Papo
Trends in biochemical sciences 41 (5), 421-433, 2016
Affinity-and specificity-enhancing mutations are frequent in multispecific interactions between TIMP2 and MMPs
O Sharabi, J Shirian, M Grossman, M Lebendiker, I Sagi, J Shifman
PloS one 9 (4), e93712, 2014
Saturation scanning of ubiquitin variants reveals a common hot spot for binding to USP2 and USP21
I Leung, A Dekel, JM Shifman, SS Sidhu
Proceedings of the National Academy of Sciences 113 (31), 8705-8710, 2016
Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP‐9 and MMP‐14
J Shirian, V Arkadash, I Cohen, T Sapir, ES Radisky, N Papo, JM Shifman
FEBS letters 592 (7), 1122-1134, 2018
RAS/Effector interactions from structural and biophysical perspective
A Erijman, JM Shifman
Mini Rev Med Chem. 16 (5), 370-375, 2016
Triathlon for energy functions: Who is the winner for design of protein–protein interactions?
O Sharabi, A Dekel, JM Shifman
Proteins: Structure, Function, and Bioinformatics 79 (5), 1487-1498, 2011
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