|Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors|
TM Loftus, DE Jaworsky, GL Frehywot, CA Townsend, GV Ronnett, ...
Science 288 (5475), 2379-2381, 2000
|Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains|
GL Challis, J Ravel, CA Townsend
Chemistry & biology 7 (3), 211-224, 2000
|Synthesis and antitumor activity of an inhibitor of fatty acid synthase|
FP Kuhajda, ES Pizer, JN Li, NS Mani, GL Frehywot, CA Townsend
Proceedings of the National Academy of Sciences 97 (7), 3450-3454, 2000
|Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts|
ES Pizer, J Thupari, WF Han, ML Pinn, FJ Chrest, GL Frehywot, ...
Cancer research 60 (2), 213-218, 2000
|Enzymology and molecular biology of aflatoxin biosynthesis|
RE Minto, CA Townsend
Chemical reviews 97 (7), 2537-2556, 1997
|Fatty acid synthase inhibition triggers apoptosis during S phase in human cancer cells|
W Zhou, PJ Simpson, JM McFadden, CA Townsend, SM Medghalchi, ...
Cancer research 63 (21), 7330-7337, 2003
|Comprehensive natural products II: chemistry and biology|
L Mander, HW Liu
|Deconstruction of iterative multidomain polyketide synthase function|
JM Crawford, PM Thomas, JR Scheerer, AL Vagstad, NL Kelleher, ...
Science 320 (5873), 243-246, 2008
|Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase|
JM Crawford, BCR Dancy, EA Hill, DW Udwary, CA Townsend
Proceedings of the National Academy of Sciences 103 (45), 16728-16733, 2006
|Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization|
JM Crawford, TP Korman, JW Labonte, AL Vagstad, EA Hill, ...
Nature 461 (7267), 1139-1143, 2009
|An externally tunable bacterial band-pass filter|
T Sohka, RA Heins, RM Phelan, JM Greisler, CA Townsend, M Ostermeier
Proceedings of the National Academy of Sciences 106 (25), 10135-10140, 2009
|Circular dichroism and magnetic circular dichroism spectroscopic studies of the non-heme ferrous active site in clavaminate synthase and its interaction with α-ketoglutarate …|
EG Pavel, J Zhou, RW Busby, M Gunsior, CA Townsend, EI Solomon
Journal of the American Chemical Society 120 (4), 743-753, 1998
|Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional α-KG-dependent non-heme iron enzyme: Correlation with mechanisms and reactivities|
J Zhou, WL Kelly, BO Bachmann, M Gunsior, CA Townsend, EI Solomon
Journal of the American Chemical Society 123 (30), 7388-7398, 2001
|New insights into the formation of fungal aromatic polyketides|
JM Crawford, CA Townsend
Nature Reviews Microbiology 8 (12), 879-889, 2010
|Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis|
SP Salowe, EN Marsh, CA Townsend
Biochemistry 29 (27), 6499-6508, 1990
|Fatty acid synthase inhibition activates AMP-activated protein kinase in SKOV3 human ovarian cancer cells|
W Zhou, WF Han, LE Landree, JN Thupari, ML Pinn, T Bililign, EK Kim, ...
Cancer research 67 (7), 2964-2971, 2007
|Expression of FAS within hypothalamic neurons: a model for decreased food intake after C75 treatment|
EK Kim, I Miller, LE Landree, FF Borisy-Rudin, P Brown, T Tihan, ...
American Journal of Physiology-Endocrinology and Metabolism 283 (5), E867-E879, 2002
|Specific abstraction of the 5'S-and 4'-deoxyribosyl hydrogen atoms from DNA by calicheamicin. gamma. 1I|
JJ Hangeland, JJ De Voss, JA Heath, CA Townsend, WD Ding, ...
Journal of the American Chemical Society 114 (23), 9200-9202, 1992
|A new class of antituberculosis agents|
PB Jones, NM Parrish, TA Houston, A Stapon, NP Bansal, JD Dick, ...
Journal of medicinal chemistry 43 (17), 3304-3314, 2000
|β-Lactam synthetase: a new biosynthetic enzyme|
BO Bachmann, R Li, CA Townsend
Proceedings of the National Academy of Sciences 95 (16), 9082-9086, 1998