| Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’chemical space: Recent progress and future challenges SD Edmondson, B Yang, C Fallan Bioorganic & Medicinal Chemistry Letters 29 (13), 1555-1564, 2019 | 324 | 2019 |
| Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1 J Wu, K Mikule, W Wang, N Su, P Petteruti, F Gharahdaghi, E Code, X Zhu, ... ACS chemical biology 8 (10), 2201-2208, 2013 | 176 | 2013 |
| Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer RF Hwang, TT Moore, MM Hattersley, M Scarpitti, B Yang, E Devereaux, ... Molecular cancer research 10 (9), 1147-1157, 2012 | 128 | 2012 |
| Asymmetric Synthesis of α-Substituted β-Amino Ketones from Sulfinimines (N-Sulfinyl Imines). Synthesis of the Indolizidine Alkaloid (−)-223A FA Davis, B Yang Journal of the American Chemical Society 127 (23), 8398-8407, 2005 | 101 | 2005 |
| Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist JS Scott, TA Moss, A Balazs, B Barlaam, J Breed, RJ Carbajo, ... Journal of medicinal chemistry 63 (23), 14530-14559, 2020 | 90 | 2020 |
| Asymmetric Synthesis of cis-5-tert-Butylproline with Metal Carbenoid NH Insertion FA Davis, B Yang, J Deng The Journal of Organic Chemistry 68 (13), 5147-5152, 2003 | 87 | 2003 |
| Discovery of AZD4573, a potent and selective inhibitor of CDK9 that enables short duration of target engagement for the treatment of hematological malignancies B Barlaam, R Casella, J Cidado, C Cook, C De Savi, A Dishington, ... Journal of Medicinal Chemistry 63 (24), 15564-15590, 2020 | 82 | 2020 |
| Direct Asymmetric Synthesis of β-Amino Ketones from Sulfinimines (N-Sulfinylimines). Synthesis of (−)-Indolizidine 209B FA Davis, B Yang Organic Letters 5 (26), 5011-5014, 2003 | 81 | 2003 |
| Optimization of 4, 6-bis-anilino-1H-pyrrolo [2, 3-d] pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity SD Chamberlain, AM Redman, JW Wilson, F Deanda, JB Shotwell, ... Bioorganic & medicinal chemistry letters 19 (2), 360-364, 2009 | 76 | 2009 |
| Asymmetric Synthesis of β-Amino Carbonyl Compounds with N-Sulfinyl β-Amino Weinreb Amides FA Davis, MB Nolt, Y Wu, KR Prasad, D Li, B Yang, K Bowen, SH Lee, ... The Journal of organic chemistry 70 (6), 2184-2190, 2005 | 73 | 2005 |
| Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening B Yang, ML Lamb, T Zhang, EJ Hennessy, G Grewal, L Sha, ... Journal of medicinal chemistry 57 (23), 9958-9970, 2014 | 49 | 2014 |
| Discovery of proteolysis-targeting chimera molecules that selectively degrade the IRAK3 pseudokinase SL Degorce, O Tavana, E Banks, C Crafter, L Gingipalli, D Kouvchinov, ... Journal of Medicinal Chemistry 63 (18), 10460-10473, 2020 | 48 | 2020 |
| Heterocyclic amides useful for the treatment of cancer and psoriasis L Dakin, B Fauber, A Hird, J Janetka, DJ Russell, Q Su, B Yang, XL Zheng US Patent App. 12/675,728, 2010 | 46 | 2010 |
| Discovery of 4, 6-bis-anilino-1H-pyrrolo [2, 3-d] pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase SD Chamberlain, JW Wilson, F Deanda, S Patnaik, AM Redman, B Yang, ... Bioorganic & medicinal chemistry letters 19 (2), 469-473, 2009 | 37 | 2009 |
| Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors AW Hird, BM Aquila, MH Block, EJ Hennessy, VM Kamhi, CA Omer, ... Bioorganic & Medicinal Chemistry Letters 24 (7), 1820-1824, 2014 | 30 | 2014 |
| Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors W McCoull, EJ Hennessy, K Blades, C Chuaqui, JE Dowling, ... ACS Medicinal Chemistry Letters 7 (12), 1118-1123, 2016 | 29 | 2016 |
| Identification and optimization of benzimidazole sulfonamides as orally bioavailable sphingosine 1-phosphate receptor 1 antagonists with in vivo activity EJ Hennessy, V Oza, A Adam, K Byth, L Castriotta, G Grewal, ... Journal of Medicinal Chemistry 58 (17), 7057-7075, 2015 | 27 | 2015 |
| Adventures in scaffold morphing: discovery of fused ring heterocyclic checkpoint kinase 1 (CHK1) inhibitors B Yang, MM Vasbinder, AW Hird, Q Su, H Wang, Y Yu, D Toader, ... Journal of Medicinal Chemistry 61 (3), 1061-1073, 2018 | 25 | 2018 |
| Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity W McCoull, EJ Hennessy, K Blades, MR Box, C Chuaqui, JE Dowling, ... MedChemComm 5 (10), 1533-1539, 2014 | 23 | 2014 |
| Small molecule inhibitor of apoptosis proteins antagonists: a patent review AW Hird, BM Aquila, EJ Hennessy, MM Vasbinder, B Yang Expert Opinion on Therapeutic Patents 25 (7), 755-774, 2015 | 22 | 2015 |
Bernard BARLAAMDrVerified email at astrazeneca.com
