Bin Yang
Bin Yang
Executive Director, Medicinal Chemistry, Kymera Therapeutics
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Proteolysis targeting chimeras (PROTACs) in ‘beyond rule-of-five’chemical space: Recent progress and future challenges
SD Edmondson, B Yang, C Fallan
Bioorganic & Medicinal Chemistry Letters 29 (13), 1555-1564, 2019
Discovery and mechanistic study of a small molecule inhibitor for motor protein KIFC1
J Wu, K Mikule, W Wang, N Su, P Petteruti, F Gharahdaghi, E Code, X Zhu, ...
ACS chemical biology 8 (10), 2201-2208, 2013
Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer
RF Hwang, TT Moore, MM Hattersley, M Scarpitti, B Yang, E Devereaux, ...
Molecular cancer research 10 (9), 1147-1157, 2012
Asymmetric Synthesis of α-Substituted β-Amino Ketones from Sulfinimines (N-Sulfinyl Imines). Synthesis of the Indolizidine Alkaloid (−)-223A
FA Davis, B Yang
Journal of the American Chemical Society 127 (23), 8398-8407, 2005
Asymmetric Synthesis of cis-5-tert-Butylproline with Metal Carbenoid NH Insertion
FA Davis, B Yang, J Deng
The Journal of Organic Chemistry 68 (13), 5147-5152, 2003
Direct Asymmetric Synthesis of β-Amino Ketones from Sulfinimines (N-Sulfinylimines). Synthesis of (−)-Indolizidine 209B
FA Davis, B Yang
Organic Letters 5 (26), 5011-5014, 2003
Asymmetric Synthesis of β-Amino Carbonyl Compounds with N-Sulfinyl β-Amino Weinreb Amides
FA Davis, MB Nolt, Y Wu, KR Prasad, D Li, B Yang, K Bowen, SH Lee, ...
The Journal of organic chemistry 70 (6), 2184-2190, 2005
Optimization of 4, 6-bis-anilino-1H-pyrrolo [2, 3-d] pyrimidine IGF-1R tyrosine kinase inhibitors towards JNK selectivity
SD Chamberlain, AM Redman, JW Wilson, F Deanda, JB Shotwell, ...
Bioorganic & medicinal chemistry letters 19 (2), 360-364, 2009
Discovery of AZD4573, a potent and selective inhibitor of CDK9 that enables short duration of target engagement for the treatment of hematological malignancies
B Barlaam, R Casella, J Cidado, C Cook, C De Savi, A Dishington, ...
Journal of Medicinal Chemistry 63 (24), 15564-15590, 2020
Discovery of AZD9833, a potent and orally bioavailable selective estrogen receptor degrader and antagonist
JS Scott, TA Moss, A Balazs, B Barlaam, J Breed, RJ Carbajo, ...
Journal of Medicinal Chemistry 63 (23), 14530-14559, 2020
Discovery of potent KIFC1 inhibitors using a method of integrated high-throughput synthesis and screening
B Yang, ML Lamb, T Zhang, EJ Hennessy, G Grewal, L Sha, ...
Journal of medicinal chemistry 57 (23), 9958-9970, 2014
Heterocyclic amides useful for the treatment of cancer and psoriasis
L Dakin, B Fauber, A Hird, J Janetka, DJ Russell, Q Su, B Yang, XL Zheng
US Patent App. 12/675,728, 2010
Discovery of 4, 6-bis-anilino-1H-pyrrolo [2, 3-d] pyrimidines: Potent inhibitors of the IGF-1R receptor tyrosine kinase
SD Chamberlain, JW Wilson, F Deanda, S Patnaik, AM Redman, B Yang, ...
Bioorganic & medicinal chemistry letters 19 (2), 469-473, 2009
Discovery of proteolysis-targeting chimera molecules that selectively degrade the IRAK3 pseudokinase
SL Degorce, O Tavana, E Banks, C Crafter, L Gingipalli, D Kouvchinov, ...
Journal of Medicinal Chemistry 63 (18), 10460-10473, 2020
Identification and optimization of benzimidazole sulfonamides as orally bioavailable sphingosine 1-phosphate receptor 1 antagonists with in vivo activity
EJ Hennessy, V Oza, A Adam, K Byth, L Castriotta, G Grewal, ...
Journal of Medicinal Chemistry 58 (17), 7057-7075, 2015
Structure-based design and synthesis of tricyclic IAP (Inhibitors of Apoptosis Proteins) inhibitors
AW Hird, BM Aquila, MH Block, EJ Hennessy, VM Kamhi, CA Omer, ...
Bioorganic & Medicinal Chemistry Letters 24 (7), 1820-1824, 2014
Optimization of highly kinase selective bis-anilino pyrimidine PAK1 inhibitors
W McCoull, EJ Hennessy, K Blades, C Chuaqui, JE Dowling, ...
ACS Medicinal Chemistry Letters 7 (12), 1118-1123, 2016
Identification and optimisation of 7-azaindole PAK1 inhibitors with improved potency and kinase selectivity
W McCoull, EJ Hennessy, K Blades, MR Box, C Chuaqui, JE Dowling, ...
MedChemComm 5 (10), 1533-1539, 2014
Adventures in scaffold morphing: discovery of fused ring heterocyclic checkpoint kinase 1 (CHK1) inhibitors
B Yang, MM Vasbinder, AW Hird, Q Su, H Wang, Y Yu, D Toader, ...
Journal of Medicinal Chemistry 61 (3), 1061-1073, 2018
Discovery of novel hedgehog antagonists from cell-based screening: Isosteric modification of p38 bisamides as potent inhibitors of SMO
B Yang, AW Hird, DJ Russell, BP Fauber, LA Dakin, X Zheng, Q Su, ...
Bioorganic & medicinal chemistry letters 22 (14), 4907-4911, 2012
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