Roman Fischer
Roman Fischer
Discovery Proteomics Facility, University of Oxford
Verified email at - Homepage
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ...
Nature 556 (7699), 113-117, 2018
Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling
J Adam, E Hatipoglu, L O'Flaherty, N Ternette, N Sahgal, H Lockstone, ...
Cancer cell 20 (4), 524-537, 2011
Colonic epithelial cell diversity in health and inflammatory bowel disease
K Parikh, A Antanaviciute, D Fawkner-Corbett, M Jagielowicz, A Aulicino, ...
Nature 567 (7746), 49-55, 2019
A late middle Pleistocene Denisovan mandible from the Tibetan Plateau
F Chen, F Welker, CC Shen, SE Bailey, I Bergmann, S Davis, H Xia, ...
nature 569 (7756), 409-412, 2019
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes
M Altun, HB Kramer, LI Willems, JL McDermott, CA Leach, SJ Goldenberg, ...
Chemistry & biology 18 (11), 1401-1412, 2011
The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation
A Hooftman, S Angiari, S Hester, SE Corcoran, MC Runtsch, C Ling, ...
Cell metabolism 32 (3), 468-478. e7, 2020
Ancient proteins resolve the evolutionary history of Darwin’s South American ungulates
F Welker, MJ Collins, JA Thomas, M Wadsley, S Brace, E Cappellini, ...
Nature 522 (7554), 81-84, 2015
Palaeoproteomic evidence identifies archaic hominins associated with the Châtelperronian at the Grotte du Renne
F Welker, M Hajdinjak, S Talamo, K Jaouen, M Dannemann, F David, ...
Proceedings of the National Academy of Sciences 113 (40), 11162-11167, 2016
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming
G Kochan, T Krojer, D Harvey, R Fischer, L Chen, M Vollmar, F von Delft, ...
Proceedings of the National Academy of Sciences 108 (19), 7745-7750, 2011
Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells
E Haythorne, M Rohm, M van de Bunt, MF Brereton, AI Tarasov, ...
Nature communications 10 (1), 2474, 2019
53BP1 cooperation with the REV7–shieldin complex underpins DNA structure-specific NHEJ
H Ghezraoui, C Oliveira, JR Becker, K Bilham, D Moralli, C Anzilotti, ...
Nature 560 (7716), 122-127, 2018
Metalloprotease SPRTN/DVC1 orchestrates replication-coupled DNA-protein crosslink repair
B Vaz, M Popovic, JA Newman, J Fielden, H Aitkenhead, S Halder, ...
Molecular cell 64 (4), 704-719, 2016
Direct evidence of milk consumption from ancient human dental calculus
C Warinner, J Hendy, C Speller, E Cappellini, R Fischer, C Trachsel, ...
Scientific reports 4 (1), 7104, 2014
Protein sequences bound to mineral surfaces persist into deep time
B Demarchi, S Hall, T Roncal-Herrero, CL Freeman, J Woolley, MK Crisp, ...
elife 5, e17092, 2016
Inhibition of mitochondrial aconitase by succination in fumarate hydratase deficiency
N Ternette, M Yang, M Laroyia, M Kitagawa, L O’Flaherty, K Wolhulter, ...
Cell reports 3 (3), 689-700, 2013
Animal origin of 13th-century uterine vellum revealed using noninvasive peptide fingerprinting
S Fiddyment, B Holsinger, C Ruzzier, A Devine, A Binois, U Albarella, ...
Proceedings of the National Academy of Sciences 112 (49), 15066-15071, 2015
Nitric oxide modulates metabolic remodeling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation
JD Bailey, M Diotallevi, T Nicol, E McNeill, A Shaw, S Chuaiphichai, ...
Cell reports 28 (1), 218-230. e7, 2019
A blood atlas of COVID-19 defines hallmarks of disease severity and specificity
DJ Ahern, Z Ai, M Ainsworth, C Allan, A Allcock, B Angus, MA Ansari, ...
Cell 185 (5), 916-938. e58, 2022
Salt-inducible kinase 2 couples ovarian cancer cell metabolism with survival at the adipocyte-rich metastatic niche
F Miranda, D Mannion, S Liu, Y Zheng, LS Mangala, C Redondo, ...
Cancer cell 30 (2), 273-289, 2016
Identification of distinct circulating exosomes in Parkinson's disease
PR Tomlinson, Y Zheng, R Fischer, R Heidasch, C Gardiner, S Evetts, ...
Annals of clinical and translational neurology 2 (4), 353-361, 2015
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