| Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis Y Zhao, P Gong, Y Chen, JC Nwachukwu, S Srinivasan, CM Ko, ... Science translational medicine 7 (271), 271ra9-271ra9, 2015 | 174 | 2015 |
| Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network JC Nwachukwu, S Srinivasan, NE Bruno, AA Parent, TS Hughes, ... elife 3, e02057, 2014 | 143 | 2014 |
| Structural mechanism for signal transduction in RXR nuclear receptor heterodimers DJ Kojetin, E Matta-Camacho, TS Hughes, S Srinivasan, JC Nwachukwu, ... Nature communications 6 (1), 8013, 2015 | 136 | 2015 |
| Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements WH Hudson, IMS Vera, JC Nwachukwu, ER Weikum, AG Herbst, Q Yang, ... Nature communications 9 (1), 1337, 2018 | 116 | 2018 |
| Structural and molecular mechanisms of cytokine-mediated endocrine resistance in human breast cancer cells JD Stender, JC Nwachukwu, I Kastrati, Y Kim, T Strid, M Yakir, ... Molecular cell 65 (6), 1122-1135. e5, 2017 | 116 | 2017 |
| Creb coactivators direct anabolic responses and enhance performance of skeletal muscle NE Bruno, KA Kelly, R Hawkins, M Bramah‐Lawani, AL Amelio, ... The EMBO journal 33 (9), 1027-1043, 2014 | 102 | 2014 |
| The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells SW Fanning, R Jeselsohn, V Dharmarajan, CG Mayne, M Karimi, ... Elife 7, e37161, 2018 | 100 | 2018 |
| Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes ER Weikum, IMS de Vera, JC Nwachukwu, WH Hudson, KW Nettles, ... Nucleic acids research 45 (14), 8596-8608, 2017 | 74 | 2017 |
| Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α S Srinivasan, JC Nwachukwu, AA Parent, V Cavett, J Nowak, TS Hughes, ... Nature chemical biology 9 (5), 326-332, 2013 | 67 | 2013 |
| Full antagonism of the estrogen receptor without a prototypical ligand side chain S Srinivasan, JC Nwachukwu, NE Bruno, V Dharmarajan, D Goswami, ... Nature chemical biology 13 (1), 111-118, 2017 | 63 | 2017 |
| Thiophene-core estrogen receptor ligands having superagonist activity J Min, P Wang, S Srinivasan, JC Nwachukwu, P Guo, M Huang, ... Journal of medicinal chemistry 56 (8), 3346-3366, 2013 | 62 | 2013 |
| Predictive features of ligand‐specific signaling through the estrogen receptor JC Nwachukwu, S Srinivasan, Y Zheng, S Wang, J Min, C Dong, Z Liao, ... Molecular Systems Biology 12 (4), 864, 2016 | 50 | 2016 |
| Structural mechanisms of allostery and autoinhibition in JNK family kinases JD Laughlin, JC Nwachukwu, M Figuera-Losada, L Cherry, KW Nettles, ... Structure 20 (12), 2174-2184, 2012 | 49 | 2012 |
| Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure–activity relationships of estrogen receptor ligands based on bridged oxabicyclic … M Zhu, C Zhang, JC Nwachukwu, S Srinivasan, V Cavett, Y Zheng, ... Organic & biomolecular chemistry 10 (43), 8692-8700, 2012 | 43 | 2012 |
| Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP P Mita, JN Savas, N Djouder, JR Yates III, S Ha, R Ruoff, ED Schafler, ... Molecular and cellular biology 31 (17), 3639-3652, 2011 | 43 | 2011 |
| Systems structural biology analysis of ligand effects on ERα predicts cellular response to environmental estrogens and anti-hormone therapies JC Nwachukwu, S Srinivasan, NE Bruno, J Nowak, NJ Wright, F Minutolo, ... Cell chemical biology 24 (1), 35-45, 2017 | 42 | 2017 |
| Identification and structure–activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo [2.2. 1] hept-2-ene-7-oxide P Wang, J Min, JC Nwachukwu, V Cavett, KE Carlson, P Guo, M Zhu, ... Journal of medicinal chemistry 55 (5), 2324-2341, 2012 | 42 | 2012 |
| First-trimester trophoblast cell model gene response to hypoxia N Koklanaris, JC Nwachukwu, SJ Huang, S Guller, K Karpisheva, ... American journal of obstetrics and gynecology 194 (3), 687-693, 2006 | 35 | 2006 |
| Development of selective estrogen receptor modulator (SERM)‐like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7 … Y Zheng, M Zhu, S Srinivasan, JC Nwachukwu, V Cavett, J Min, ... ChemMedChem 7 (6), 1094-1100, 2012 | 33 | 2012 |
| Dual-mechanism estrogen receptor inhibitors J Min, JC Nwachukwu, CK Min, JW Njeri, S Srinivasan, ES Rangarajan, ... Proceedings of the National Academy of Sciences 118 (35), e2101657118, 2021 | 30 | 2021 |
