Ina Urbatsch
Ina Urbatsch
Professor of Cell Biology and Biochemistry
Verified email at - Homepage
Cited by
Cited by
Structure of P-glycoprotein reveals a molecular basis for poly-specific drug binding
SG Aller, J Yu, A Ward, Y Weng, S Chittaboina, R Zhuo, PM Harrell, ...
Science 323 (5922), 1718-1722, 2009
The catalytic cycle of P-glycoprotein
AE Senior, MK Al-Shawi, IL Urbatsch
FEBS letters 377 (3), 285-289, 1995
P-glycoprotein Is Stably Inhibited by Vanadate-induced Trapping of Nucleotide at a Single Catalytic Site (∗)
IL Urbatsch, B Sankaran, J Weber, AE Senior
Journal of Biological Chemistry 270 (33), 19383-19390, 1995
Both P-glycoprotein nucleotide-binding sites are catalytically active
IL Urbatsch, B Sankaran, S Bhagat, AE Senior
Journal of Biological Chemistry 270 (45), 26956-26961, 1995
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain
AB Ward, P Szewczyk, V Grimard, CW Lee, L Martinez, R Doshi, A Caya, ...
Proceedings of the National Academy of Sciences 110 (33), 13386-13391, 2013
Characterization of the ATPase activity of purified Chinese hamster P-glycoprotein
IL Urbatsch, MK Al-Shawi, AE Senior
Biochemistry 33 (23), 7069-7076, 1994
Crystal structure of the human sterol transporter ABCG5/ABCG8
JY Lee, LN Kinch, DM Borek, J Wang, J Wang, IL Urbatsch, XS Xie, ...
Nature 533 (7604), 561-564, 2016
Bradford assay for determining protein concentration
CL Kielkopf, W Bauer, IL Urbatsch
Cold Spring Harbor Protocols 2020 (4), pdb. prot102269, 2020
Covalent inhibitors of P-glycoprotein ATPase activity.
MK Al-Shawi, IL Urbatsch, AE Senior
Journal of Biological Chemistry 269 (12), 8986-8992, 1994
Large scale purification of detergent-soluble p-glycoprotein frompichia pastoris cells and characterization of nucleotide binding properties of wild-type, walker a, and walker …
N Lerner-Marmarosh, K Gimi, IL Urbatsch, P Gros, AE Senior
Journal of Biological Chemistry 274 (49), 34711-34718, 1999
Snapshots of ligand entry, malleable binding and induced helical movement in P-glycoprotein
P Szewczyk, H Tao, AP McGrath, M Villaluz, SD Rees, SC Lee, R Doshi, ...
Acta Crystallographica Section D: Biological Crystallography 71 (3), 732-741, 2015
Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites
IL Urbatsch, L Beaudet, I Carrier, P Gros
Biochemistry 37 (13), 4592-4602, 1998
Understanding polyspecificity of multidrug ABC transporters: closing in on the gaps in ABCB1
DAP Gutmann, A Ward, IL Urbatsch, G Chang, HW van Veen
Trends in biochemical sciences 35 (1), 36-42, 2010
Effects of lipids on ATPase activity of purified Chinese hamster P-glycoprotein
IL Urbatsch, AE Senior
Archives of biochemistry and biophysics 316 (1), 135-140, 1995
A gene optimization strategy that enhances production of fully functional P-glycoprotein in Pichia pastoris
J Bai, DJ Swartz, II Protasevich, CG Brouillette, PM Harrell, E Hildebrandt, ...
PloS one 6 (8), e22577, 2011
Projection structure of P-glycoprotein by electron microscopy: evidence for a closed conformation of the nucleotide binding domains
JY Lee, IL Urbatsch, AE Senior, S Wilkens
Journal of Biological Chemistry 277 (42), 40125-40131, 2002
Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly
G Tombline, LA Bartholomew, IL Urbatsch, AE Senior
Journal of Biological Chemistry 279 (30), 31212-31220, 2004
Distinct conformational spectrum of homologous multidrug ABC transporters
A Moeller, SC Lee, H Tao, JA Speir, G Chang, IL Urbatsch, CS Potter, ...
Structure 23 (3), 450-460, 2015
P-glycoprotein catalytic mechanism: studies of the ADP-vanadate inhibited state
IL Urbatsch, GA Tyndall, G Tombline, AE Senior
Journal of Biological Chemistry 278 (25), 23171-23179, 2003
Mutational analysis of conserved carboxylate residues in the nucleotide binding sites of P-glycoprotein
IL Urbatsch, M Julien, I Carrier, ME Rousseau, R Cayrol, P Gros
Biochemistry 39 (46), 14138-14149, 2000
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