Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index EK Speliotes, CJ Willer, SI Berndt, KL Monda, G Thorleifsson, AU Jackson, ... Nature genetics 42 (11), 937-948, 2010 | 2899 | 2010 |
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution IM Heid, AU Jackson, JC Randall, TW Winkler, L Qi, V Steinthorsdottir, ... Nature genetics 42 (11), 949-960, 2010 | 895 | 2010 |
The genetic architecture of type 2 diabetes C Fuchsberger, J Flannick, TM Teslovich, A Mahajan, V Agarwala, ... Nature 536 (7614), 41-47, 2016 | 779 | 2016 |
A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes I Moltke, N Grarup, ME Jørgensen, P Bjerregaard, JT Treebak, ... Nature 512 (7513), 190-193, 2014 | 271 | 2014 |
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes JRB Perry, MN Weedon, C Langenberg, AU Jackson, V Lyssenko, ... Human molecular genetics 19 (3), 535-544, 2010 | 205 | 2010 |
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension P Surendran, F Drenos, R Young, H Warren, JP Cook, AK Manning, ... Nature genetics 48 (10), 1151-1161, 2016 | 177 | 2016 |
The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes T Sparsø, G Andersen, T Nielsen, KS Burgdorf, AP Gjesing, AL Nielsen, ... Diabetologia 51 (1), 70-75, 2008 | 172 | 2008 |
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity V Turcot, Y Lu, HM Highland, C Schurmann, AE Justice, RS Fine, ... Nature genetics 50 (1), 26-41, 2018 | 152 | 2018 |
Genetic evidence of assortative mating in humans MR Robinson, A Kleinman, M Graff, AAE Vinkhuyzen, D Couper, ... Nature Human Behaviour 1 (1), 1-13, 2017 | 142 | 2017 |
G-allele of intronic rs10830963 in MTNR1B confers increased risk of impaired fasting glycemia and type 2 diabetes through an impaired glucose-stimulated insulin release … T Sparsø, A Bonnefond, E Andersson, N Bouatia-Naji, J Holmkvist, ... Diabetes 58 (6), 1450-1456, 2009 | 140 | 2009 |
Genome-wide population-based association study of extremely overweight young adults–the GOYA study L Paternoster, DM Evans, EA Nohr, C Holst, V Gaborieau, P Brennan, ... PloS one 6 (9), e24303, 2011 | 129 | 2011 |
Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes K Bacos, L Gillberg, P Volkov, AH Olsson, T Hansen, O Pedersen, ... Nature communications 7 (1), 1-13, 2016 | 124 | 2016 |
Association of a functional 17β-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females OP Kristiansen, RL Nolsøe, L Larsen, AMP Gjesing, J Johannesen, ... Human molecular genetics 12 (10), 1101-1110, 2003 | 86 | 2003 |
Studies of the associations between functional β 2-adrenergic receptor variants and obesity, hypertension and type 2 diabetes in 7,808 white subjects AP Gjesing, G Andersen, KS Burgdorf, K Borch-Johnsen, T Jørgensen, ... Diabetologia 50 (3), 563-568, 2007 | 85 | 2007 |
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus A Mahajan, X Sim, HJ Ng, A Manning, MA Rivas, HM Highland, AE Locke, ... PLoS Genet 11 (1), e1004876, 2015 | 83 | 2015 |
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes I Miguel-Escalada, S Bonàs-Guarch, I Cebola, J Ponsa-Cobas, ... Nature genetics 51 (7), 1137-1148, 2019 | 70 | 2019 |
The CTRB1/2 locus affects diabetes susceptibility and treatment via the incretin pathway L M‘t Hart, A Fritsche, G Nijpels, N van Leeuwen, LA Donnelly, JM Dekker, ... Diabetes 62 (9), 3275-3281, 2013 | 63 | 2013 |
Variant near ADAMTS9 known to associate with type 2 diabetes is related to insulin resistance in offspring of type 2 diabetes patients—EUGENE2 study TW Boesgaard, AP Gjesing, N Grarup, J Rutanen, PA Jansson, ML Hribal, ... PloS one 4 (9), e7236, 2009 | 62 | 2009 |
Mutation analysis of the preproghrelin gene: no association with obesity and type 2 diabetes LH Larsen, AP Gjesing, TIA Sørensen, YH Hamid, SM Echwald, S Toubro, ... Clinical Biochemistry 38 (5), 420-424, 2005 | 59 | 2005 |
Large-scale studies of the Hph I insulin gene variable-number-of-tandem-repeats polymorphism in relation to Type 2 diabetes mellitus and insulin release SK Hansen, AP Gjesing, SK Rasmussen, C Glümer, SA Urhammer, ... Diabetologia 47 (6), 1079-1087, 2004 | 59 | 2004 |