Optimisation and validation of a medium-throughput electrophysiology-based hERG assay using IonWorks™ HT MH Bridgland-Taylor, AC Hargreaves, A Easter, A Orme, DC Henthorn, ... Journal of pharmacological and toxicological methods 54 (2), 189-199, 2006 | 177 | 2006 |
Development of a multicompartment permeability‐limited lung PBPK model and its application in predicting pulmonary pharmacokinetics of antituberculosis drugs L Gaohua, J Wedagedera, BG Small, L Almond, K Romero, D Hermann, ... CPT: pharmacometrics & systems pharmacology 4 (10), 605-613, 2015 | 88 | 2015 |
Efficient discovery of anti-inflammatory small-molecule combinations using evolutionary computing BG Small, BW McColl, R Allmendinger, J Pahle, G López-Castejón, ... Nature Chemical Biology 7 (12), 902-908, 2011 | 77 | 2011 |
Optimisation and validation of a medium-throughput electrophysiology-based hNav1. 5 assay using IonWorks™ AR Harmer, N Abi-Gerges, A Easter, A Woods, CL Lawrence, BG Small, ... Journal of pharmacological and toxicological methods 57 (1), 30-41, 2008 | 68 | 2008 |
LY339434, a GluR5 kainate receptor agonist B Small, J Thomas, M Kemp, K Hoo, B Ballyk, M Deverill, AM Ogden, ... Neuropharmacology 37 (10-11), 1261-1267, 1998 | 54 | 1998 |
Evidence for gender differences in electrophysiological properties of canine Purkinje fibres N Abi‐Gerges, BG Small, CL Lawrence, TG Hammond, JP Valentin, ... British journal of pharmacology 142 (8), 1255-1264, 2004 | 46 | 2004 |
Gender differences in the slow delayed (IKs) but not in inward (IK1) rectifier K+ currents of canine Purkinje fibre cardiac action potential: key roles for IKs, β‐adrenoceptor … N Abi‐Gerges, BG Small, CL Lawrence, TG Hammond, JP Valentin, ... British journal of pharmacology 147 (6), 653-660, 2006 | 42 | 2006 |
Increasing application of pediatric physiologically based pharmacokinetic models across academic and industry organizations TN Johnson, BG Small, K Rowland Yeo CPT: Pharmacometrics & Systems Pharmacology 11 (3), 373-383, 2022 | 29 | 2022 |
Validation of a voltage-sensitive dye (di-4-ANEPPS)-based method for assessing drug-induced delayed repolarisation in beagle dog left ventricular midmyocardial myocytes MEL Hardy, CE Pollard, BG Small, M Bridgland-Taylor, AJ Woods, ... Journal of pharmacological and toxicological methods 60 (1), 94-106, 2009 | 29 | 2009 |
Integration of omics data sources to inform mechanistic modeling of immune‐oncology therapies: a tutorial for clinical pharmacologists G Lazarou, V Chelliah, BG Small, M Walker, PH van der Graaf, ... Clinical Pharmacology & Therapeutics 107 (4), 858-870, 2020 | 28 | 2020 |
A quantitative systems pharmacology consortium approach to managing immunogenicity of therapeutic proteins AM Kierzek, TP Hickling, I Figueroa, JC Kalvass, M Nijsen, K Mohan, ... CPT: Pharmacometrics & Systems Pharmacology 8 (11), 773, 2019 | 23 | 2019 |
Prediction of liver volume–a population‐based approach to meta‐analysis of paediatric, adult and geriatric populations–an update BG Small, B Wendt, M Jamei, TN Johnson Biopharmaceutics & drug disposition 38 (4), 290-300, 2017 | 23 | 2017 |
Early assessment of proarrhythmic risk of drugs using the in vitro data and single-cell-based in silico models: proof of concept M Abbasi, BG Small, N Patel, M Jamei, S Polak Toxicology Mechanisms and Methods 27 (2), 88-99, 2017 | 17 | 2017 |
A best practice framework for applying physiologically‐based pharmacokinetic modeling to pediatric drug development TN Johnson, BG Small, EG Berglund, K Rowland Yeo CPT: Pharmacometrics & Systems Pharmacology 10 (9), 967-972, 2021 | 12 | 2021 |
Development of physiologically‐based pharmacokinetic models for standard of care and newer tuberculosis drugs H Humphries, L Almond, A Berg, I Gardner, O Hatley, X Pan, B Small, ... CPT: Pharmacometrics & Systems Pharmacology 10 (11), 1382-1395, 2021 | 8 | 2021 |
Development and application of a pediatric mechanistic kidney model F Salem, BG Small, TN Johnson CPT: Pharmacometrics & Systems Pharmacology 11 (7), 854-866, 2022 | 7 | 2022 |
Development of a Multicompartment Permeability-Limited Lung PBPK Model and Its Application in Predicting Pulmonary Pharmacokinetics of Antituberculosis Drugs. CPT … L Gaohua, J Wedagedera, BG Small, L Almond, K Romero, D Hermann, ... | 7 | |
Another step toward qualification of pediatric physiologically based pharmacokinetic models to facilitate inclusivity and diversity in pediatric clinical studies BG Small, TN Johnson, K Rowland Yeo Clinical Pharmacology & Therapeutics 113 (3), 735-745, 2023 | 6 | 2023 |
LY339434, a GluR5-selective kainate receptor agonist BG Small, SR Baker, A Rubio, EF Sharpe, BA Ballyk, K Hoo, A Mandelzys, ... BRITISH JOURNAL OF PHARMACOLOGY 122, 59P-59P, 1997 | 5 | 1997 |
Development of a novel multi-compartment granuloma model to predict local drug distribution and its impact on pharmacodynamics and disease progression in tuberculosis RH Rose, L Gaohua, J Wedagedera, BG Small, A Barnett, K Romero, ... Proceedings of the PAGE Conference, Lisboa, Portugal, 7-10, 2016 | 3 | 2016 |