Michael Downes
Michael Downes
Senior Staff Scientist, Salk Insititute
Verified email at salk.edu
Cited by
Cited by
The genome sequence of Drosophila melanogaster
MD Adams, SE Celniker, RA Holt, CA Evans, JD Gocayne, ...
Science 287 (5461), 2185-2195, 2000
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
R Lister, M Pelizzola, YS Kida, RD Hawkins, JR Nery, G Hon, ...
Nature 471 (7336), 68-73, 2011
PPARγ signaling and metabolism: the good, the bad and the future
M Ahmadian, JM Suh, N Hah, C Liddle, AR Atkins, M Downes, RM Evans
Nature medicine 19 (5), 557-566, 2013
AMPK and PPARδ agonists are exercise mimetics
VA Narkar, M Downes, TY Ruth, E Embler, YX Wang, E Banayo, ...
Cell 134 (3), 405-415, 2008
Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network
AL Bookout, Y Jeong, M Downes, TY Ruth, RM Evans, DJ Mangelsdorf
Cell 126 (4), 789-799, 2006
Nuclear receptor expression links the circadian clock to metabolism
X Yang, M Downes, TY Ruth, AL Bookout, W He, M Straume, ...
Cell 126 (4), 801-810, 2006
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
T Inagaki, A Moschetta, YK Lee, L Peng, G Zhao, M Downes, TY Ruth, ...
Proceedings of the National Academy of Sciences 103 (10), 3920-3925, 2006
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
H Cho, X Zhao, M Hatori, TY Ruth, GD Barish, MT Lam, LW Chong, ...
Nature 485 (7396), 123-127, 2012
Humanized xenobiotic response in mice expressing nuclear receptor SXR
W Xie, JL Barwick, M Downes, B Blumberg, CM Simon, MC Nelson, ...
Nature 406 (6794), 435-439, 2000
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
HY Kao, P Ordentlich, N Koyano-Nakagawa, Z Tang, M Downes, ...
Genes & development 12 (15), 2269-2277, 1998
Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy
MH Sherman, TY Ruth, DD Engle, N Ding, AR Atkins, H Tiriac, ...
Cell 159 (1), 80-93, 2014
Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
HY Kao, M Downes, P Ordentlich, RM Evans
Genes & development 14 (1), 55-66, 2000
Class IIa histone deacetylases are hormone-activated regulators of FOXO and mammalian glucose homeostasis
MM Mihaylova, DS Vasquez, K Ravnskjaer, PD Denechaud, TY Ruth, ...
Cell 145 (4), 607-621, 2011
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
S Fang, JM Suh, SM Reilly, E Yu, O Osborn, D Lackey, E Yoshihara, ...
Nature medicine 21 (2), 159-165, 2015
A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response
N Ding, TY Ruth, N Subramaniam, MH Sherman, C Wilson, R Rao, ...
Cell 153 (3), 601-613, 2013
Cryptochromes mediate rhythmic repression of the glucocorticoid receptor
KA Lamia, SJ Papp, TY Ruth, GD Barish, NH Uhlenhaut, JW Jonker, ...
Nature 480 (7378), 552-556, 2011
Genome-wide orchestration of cardiac functions by the orphan nuclear receptors ERRα and γ
CR Dufour, BJ Wilson, JM Huss, DP Kelly, WA Alaynick, M Downes, ...
Cell metabolism 5 (5), 345-356, 2007
Sharp, an inducible cofactor that integrates nuclear receptor repression and activation
Y Shi, M Downes, W Xie, HY Kao, P Ordentlich, CC Tsai, M Hon, ...
Genes & development 15 (9), 1140-1151, 2001
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
M Downes, MA Verdecia, AJ Roecker, R Hughes, JB Hogenesch, ...
Molecular cell 11 (4), 1079-1092, 2003
An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice
SM Reilly, SH Chiang, SJ Decker, L Chang, M Uhm, MJ Larsen, JR Rubin, ...
Nature medicine 19 (3), 313-321, 2013
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