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John Talpos
John Talpos
National Center for Toxicological Research
Verified email at fda.hhs.gov
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NMDA receptors, cognition and schizophrenia–testing the validity of the NMDA receptor hypofunction hypothesis
G Gilmour, S Dix, L Fellini, F Gastambide, N Plath, T Steckler, J Talpos, ...
Neuropharmacology 62 (3), 1401-1412, 2012
2172012
Animal models of working memory: a review of tasks that might be used in screening drug treatments for the memory impairments found in schizophrenia
PA Dudchenko, J Talpos, J Young, MG Baxter
Neuroscience & Biobehavioral Reviews 37 (9), 2111-2124, 2013
1522013
A novel touchscreen-automated paired-associate learning (PAL) task sensitive to pharmacological manipulation of the hippocampus: a translational rodent model of cognitive …
JC Talpos, BD Winters, R Dias, LM Saksida, TJ Bussey
Psychopharmacology 205, 157-168, 2009
1332009
Biased mGlu5-positive allosteric modulators provide in vivo efficacy without potentiating mGlu5 modulation of NMDAR currents
JM Rook, Z Xiang, X Lv, A Ghoshal, JW Dickerson, TM Bridges, ...
Neuron 86 (4), 1029-1040, 2015
1282015
Trial-unique, delayed nonmatching-to-location (TUNL): a novel, highly hippocampus-dependent automated touchscreen test of location memory and pattern separation
JC Talpos, SM McTighe, R Dias, LM Saksida, TJ Bussey
Neurobiology of learning and memory 94 (3), 341-352, 2010
1282010
A comparison of multiple 5-HT receptors in two tasks measuring impulsivity
JC Talpos, LS Wilkinson, TW Robbins
Journal of Psychopharmacology 20 (1), 47-58, 2006
1202006
Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives
MJ Kas, JC Glennon, J Buitelaar, E Ey, B Biemans, J Crawley, RH Ring, ...
Psychopharmacology 231, 1125-1146, 2014
1092014
Can SARS-CoV-2 infect the central nervous system via the olfactory bulb or the blood-brain barrier?
SM Burks, H Rosas-Hernandez, MA Ramirez-Lee, E Cuevas, JC Talpos
Brain, behavior, and immunity 95, 7-14, 2021
732021
Strain-dependent effects on acquisition and reversal of visual and spatial tasks in a rat touchscreen battery of cognition
G Kumar, J Talpos, T Steckler
Physiology & behavior 144, 26-36, 2015
572015
The pharmacological sensitivity of a touchscreen-based visual discrimination task in the rat using simple and perceptually challenging stimuli
JC Talpos, AC Fletcher, C Circelli, MD Tricklebank, SL Dix
Psychopharmacology 221, 437-449, 2012
512012
Hippocampal lesions in rats impair learning and memory for locations on a touch-sensitive computer screen: the “ASAT” task
JC Talpos, R Dias, TJ Bussey, LM Saksida
Behavioural brain research 192 (2), 216-225, 2008
512008
Touching on translation
J Talpos, T Steckler
Cell and tissue research 354 (1), 297-308, 2013
492013
A touch-screen based paired-associates learning (PAL) task for the rat may provide a translatable pharmacological model of human cognitive impairment
JC Talpos, N Aerts, L Fellini, T Steckler
Pharmacology Biochemistry and Behavior 122, 97-106, 2014
482014
The subchronic phencyclidine rat model: relevance for the assessment of novel therapeutics for cognitive impairment associated with schizophrenia
SK Janhunen, H Svärd, J Talpos, G Kumar, T Steckler, N Plath, L Lerdrup, ...
Psychopharmacology 232, 4059-4083, 2015
462015
Severe cross-modal object recognition deficits in rats treated sub-chronically with NMDA receptor antagonists are reversed by systemic nicotine: implications for abnormal …
DL Jacklin, A Goel, KJ Clementino, AWM Hall, JC Talpos, BD Winters
Neuropsychopharmacology 37 (10), 2322-2331, 2012
432012
Dissociable effects of NR2A and NR2B NMDA receptor antagonism on cognitive flexibility but not pattern separation
G Kumar, J Olley, T Steckler, J Talpos
Psychopharmacology 232, 3991-4003, 2015
412015
Animal models and measures of perceptual processing in schizophrenia
SJ Siegel, JC Talpos, MA Geyer
Neuroscience & Biobehavioral Reviews 37 (9), 2092-2098, 2013
392013
Early life exposure to extended general anesthesia with isoflurane and nitrous oxide reduces responsivity on a cognitive test battery in the nonhuman primate
JC Talpos, JJ Chelonis, M Li, JP Hanig, MG Paule
Neurotoxicology 70, 80-90, 2019
362019
Executive function
J Talpos, M Shoaib
Cognitive Enhancement, 191-213, 2015
302015
Re-evaluating the PCP challenge as a pre-clinical model of impaired cognitive flexibility in schizophrenia
L Fellini, G Kumar, S Gibbs, T Steckler, J Talpos
European Neuropsychopharmacology 24 (11), 1836-1849, 2014
282014
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