RNAi-mediated gene-targeting through systemic application of polyethylenimine (PEI)-complexed siRNA in vivo B Urban-Klein, S Werth, S Abuharbeid, F Czubayko, A Aigner Gene therapy 12 (5), 461-466, 2005 | 982 | 2005 |
Immunolocalization of an FGF-binding protein reveals a widespread expression pattern during different stages of mouse embryo development A Aigner, PE Ray, F Czubayko, A Wellstein Histochemistry and cell biology 117, 1-11, 2002 | 654 | 2002 |
Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin GE Stoica, A Kuo, A Aigner, I Sunitha, B Souttou, C Malerczyk, ... Journal of Biological Chemistry 276 (20), 16772-16779, 2001 | 511 | 2001 |
MicroRNA replacement therapy for miR-145 and miR-33a is efficacious in a model of colon carcinoma AF Ibrahim, U Weirauch, M Thomas, A Grünweller, RK Hartmann, ... Cancer research 71 (15), 5214-5224, 2011 | 451 | 2011 |
Poly (vinyl alcohol) nanofibers by electrospinning as a protein delivery system and the retardation of enzyme release by additional polymer coatings J Zeng, A Aigner, F Czubayko, T Kissel, JH Wendorff, A Greiner Biomacromolecules 6 (3), 1484-1488, 2005 | 430 | 2005 |
A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes S Werth, B Urban-Klein, L Dai, S Höbel, M Grzelinski, U Bakowsky, ... Journal of controlled release 112 (2), 257-270, 2006 | 402 | 2006 |
RNA Interference-Mediated Gene Silencing of Pleiotrophin Through Polyethylenimine-Complexed Small Interfering RNAs In Vivo Exerts Antitumoral Effects in … M Grzelinski, B Urban-Klein, T Martens, K Lamszus, U Bakowsky, S Höbel, ... Human gene therapy 17 (7), 751-766, 2006 | 328 | 2006 |
A secreted FGF-binding protein can serve as the angiogenic switch in human cancer F Czubayko, EDE Liaudet-Coopman, A Aigner, AT Tuveson, GJ Berchem, ... Nature medicine 3 (10), 1137-1140, 1997 | 309 | 1997 |
Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs A Aigner Journal of biotechnology 124 (1), 12-25, 2006 | 299 | 2006 |
Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth C Powers, A Aigner, GE Stoica, K McDonnell, A Wellstein Journal of Biological Chemistry 277 (16), 14153-14158, 2002 | 253 | 2002 |
Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells N Ertych, A Stolz, A Stenzinger, W Weichert, S Kaulfuß, P Burfeind, ... Nature cell biology 16 (8), 779-791, 2014 | 234 | 2014 |
Liposome–polyethylenimine complexes for enhanced DNA and siRNA delivery J Schäfer, S Höbel, U Bakowsky, A Aigner Biomaterials 31 (26), 6892-6900, 2010 | 232 | 2010 |
Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung M Günther, J Lipka, A Malek, D Gutsch, W Kreyling, A Aigner European Journal of Pharmaceutics and Biopharmaceutics 77 (3), 438-449, 2011 | 224 | 2011 |
Polyethylenimines for siRNA and miRNA delivery in vivo S Höbel, A Aigner Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology 5 (5 …, 2013 | 223 | 2013 |
Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo A Aigner BioMed Research International 2006 (1), 071659, 2006 | 219 | 2006 |
In vivo pharmacokinetics, tissue distribution and underlying mechanisms of various PEI (–PEG)/siRNA complexes A Malek, O Merkel, L Fink, F Czubayko, T Kissel, A Aigner Toxicology and applied pharmacology 236 (1), 97-108, 2009 | 216 | 2009 |
The host defence peptide LL-37/hCAP-18 is a growth factor for lung cancer cells J von Haussen, R Koczulla, R Shaykhiev, C Herr, O Pinkenburg, ... Lung cancer 59 (1), 12-23, 2008 | 215 | 2008 |
Therapeutic siRNA: state-of-the-art and future perspectives M Friedrich, A Aigner BioDrugs 36 (5), 549-571, 2022 | 214 | 2022 |
From the exposome to mechanistic understanding of chemical-induced adverse effects BI Escher, J Hackermüller, T Polte, S Scholz, A Aigner, R Altenburger, ... Environment international 99, 97-106, 2017 | 206 | 2017 |
Enhancement of fibroblast growth factor (FGF) activity by an FGF-binding protein E Tassi, A Al-Attar, A Aigner, MR Swift, K McDonnell, A Karavanov, ... Journal of Biological Chemistry 276 (43), 40247-40253, 2001 | 192 | 2001 |