Identification of the gene that codes for the σ2 receptor A Alon, HR Schmidt, MD Wood, JJ Sahn, SF Martin, AC Kruse Proceedings of the National Academy of Sciences 114 (27), 7160-7165, 2017 | 281 | 2017 |
Improved molecular replacement by density-and energy-guided protein structure optimization F DiMaio, TC Terwilliger, RJ Read, A Wlodawer, G Oberdorfer, U Wagner, ... Nature 473 (7348), 540-543, 2011 | 264 | 2011 |
A secreted disulfide catalyst controls extracellular matrix composition and function T Ilani, A Alon, I Grossman, B Horowitz, E Kartvelishvily, SR Cohen, ... Science 341 (6141), 74-76, 2013 | 163 | 2013 |
Drug-induced phospholipidosis confounds drug repurposing for SARS-CoV-2 TA Tummino, VV Rezelj, B Fischer, A Fischer, MJ O’meara, B Monel, ... Science 373 (6554), 541-547, 2021 | 162 | 2021 |
COVID-19: famotidine, histamine, mast cells, and mechanisms RW Malone, P Tisdall, P Fremont-Smith, Y Liu, XP Huang, KM White, ... Frontiers in Pharmacology 12, 633680, 2021 | 151 | 2021 |
Structures of the σ2 receptor enable docking for bioactive ligand discovery A Alon, J Lyu, JM Braz, TA Tummino, V Craik, MJ O’Meara, CM Webb, ... Nature 600 (7890), 759-764, 2021 | 128 | 2021 |
AbDesign: An algorithm for combinatorial backbone design guided by natural conformations and sequences GD Lapidoth, D Baran, GM Pszolla, C Norn, A Alon, MD Tyka, ... Proteins: Structure, Function, and Bioinformatics 83 (8), 1385-1406, 2015 | 110 | 2015 |
Human quiescin-sulfhydryl oxidase, QSOX1: probing internal redox steps by mutagenesis EJ Heckler, A Alon, D Fass, C Thorpe Biochemistry 47 (17), 4955-4963, 2008 | 92 | 2008 |
The dynamic disulphide relay of quiescin sulphydryl oxidase A Alon, I Grossman, Y Gat, VK Kodali, F DiMaio, T Mehlman, G Haran, ... Nature 488 (7411), 414-418, 2012 | 91 | 2012 |
QSOX contains a pseudo-dimer of functional and degenerate sulfhydryl oxidase domains A Alon, EJ Heckler, C Thorpe, D Fass FEBS letters 584 (8), 1521-1525, 2010 | 57 | 2010 |
An inhibitory antibody blocks the first step in the dithiol/disulfide relay mechanism of the enzyme QSOX1 I Grossman, A Alon, T Ilani, D Fass Journal of molecular biology 425 (22), 4366-4378, 2013 | 34 | 2013 |
Dormant spores sense amino acids through the B subunits of their germination receptors L Artzi, A Alon, KP Brock, AG Green, A Tam, FH Ramírez-Guadiana, ... Nature Communications 12 (1), 6842, 2021 | 27 | 2021 |
The SpoVA membrane complex is required for dipicolinic acid import during sporulation and export during germination Y Gao, RDC Barajas-Ornelas, JD Amon, FH Ramírez-Guadiana, A Alon, ... Genes & Development 36 (9-10), 634-646, 2022 | 24 | 2022 |
Structural perspectives on sigma-1 receptor function A Alon, H Schmidt, S Zheng, AC Kruse Sigma Receptors: Their Role in Disease and as Therapeutic Targets, 5-13, 2017 | 18 | 2017 |
Exploring ORFan domains in giant viruses: structure of mimivirus sulfhydryl oxidase R596 M Hakim, D Ezerina, A Alon, O Vonshak, D Fass PLoS One 7 (11), e50649, 2012 | 18 | 2012 |
cis‐Proline mutants of quiescin sulfhydryl oxidase 1 with altered redox properties undermine extracellular matrix integrity and cell adhesion in fibroblast cultures G Javitt, I Grossman‐Haham, A Alon, E Resnick, Y Mutsafi, T Ilani, D Fass Protein Science 28 (1), 228-238, 2019 | 13 | 2019 |
Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2 TA Tummino, VV Rezelj, B Fischer, A Fischer, MJ O’Meara, B Monel, ... bioRxiv, 2021 | 9 | 2021 |
Phylogenetics and enzymology of plant quiescin sulfhydryl oxidase K Limor-Waisberg, A Alon, T Mehlman, D Fass FEBS letters 586 (23), 4119-4125, 2012 | 9 | 2012 |
Crystal structures of the σ2 receptor template large-library docking for selective chemotypes active in vivo A Alon, J Lyu, JM Braz, TA Tummino, V Craik, MJ O’Meara, CM Webb, ... bioRxiv, 2021.04. 29.441652, 2021 | 7 | 2021 |
Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential LDJ Schiffelers, S Normann, SC Binder, E Hagelauer, A Kopp, A Alon, ... bioRxiv, 2023.04. 20.537718, 2023 | 4 | 2023 |