Christopher Vockley
Christopher Vockley
Broad Institute of MIT and Harvard
Verified email at
Cited by
Cited by
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
IB Hilton, AM D'ippolito, CM Vockley, PI Thakore, GE Crawford, TE Reddy, ...
Nature biotechnology 33 (5), 510-517, 2015
RNA-guided gene activation by CRISPR-Cas9–based transcription factors
P Perez-Pinera, DD Kocak, CM Vockley, AF Adler, AM Kabadi, ...
Nature methods 10 (10), 973-976, 2013
Expanded encyclopaedias of DNA elements in the human and mouse genomes
JE Moore, MJ Purcaro, HE Pratt, CB Epstein, N Shoresh, J Adrian, T Kawli, ...
Nature 583 (7818), 699-710, 2020
Direct GR Binding Sites Potentiate Clusters of TF Binding across the Human Genome
CM Vockley, AM D’Ippolito, IC McDowell, WH Majoros, A Safi, L Song, ...
Cell 166 (5), 1269-1281. e19, 2016
Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE-and CRISPR/Cas9-based transcriptional activators
LR Polstein, P Perez-Pinera, DD Kocak, CM Vockley, P Bledsoe, L Song, ...
Genome research 25 (8), 1158-1169, 2015
Regulation of chromatin accessibility and Zic binding at enhancers in the developing cerebellum
CL Frank, F Liu, R Wijayatunge, L Song, MT Biegler, MG Yang, ...
Nature neuroscience 18 (5), 647-656, 2015
Clustering gene expression time series data using an infinite Gaussian process mixture model
IC McDowell, D Manandhar, CM Vockley, AK Schmid, TE Reddy, ...
PLoS computational biology 14 (1), e1005896, 2018
Massively parallel quantification of the regulatory effects of noncoding genetic variation in a human cohort
CM Vockley, C Guo, WH Majoros, M Nodzenski, DM Scholtens, ...
Genome research 25 (8), 1206-1214, 2015
Evidence for multiple roles for grainyheadlike 2 in the establishment and maintenance of human mucociliary airway epithelium
X Gao, CM Vockley, F Pauli, KM Newberry, Y Xue, SH Randell, TE Reddy, ...
Proceedings of the National Academy of Sciences 110 (23), 9356-9361, 2013
Genome-wide quantification of the effects of DNA methylation on human gene regulation
AJ Lea, CM Vockley, RA Johnston, CA Del Carpio, LB Barreiro, TE Reddy, ...
eLife 7, e37513, 2018
Glucocorticoid receptor recruits to enhancers and drives activation by motif-directed binding
IC McDowell, A Barrera, AM D'Ippolito, CM Vockley, LK Hong, ...
Genome research 28 (9), 1272-1284, 2018
Pre-established chromatin interactions mediate the genomic response to glucocorticoids
AM D'Ippolito, IC McDowell, A Barrera, LK Hong, SM Leichter, LC Bartelt, ...
Cell systems 7 (2), 146-160. e7, 2018
Perspectives on ENCODE
MP Snyder, TR Gingeras, JE Moore, Z Weng, MB Gerstein, B Ren, ...
Nature 583 (7818), 693-698, 2020
Detection and characterization of silencers and enhancer-blockers in the greater CFTR locus
HM Petrykowska, CM Vockley, L Elnitski
Genome research 18 (8), 1238-1246, 2008
Human genome-wide measurement of drug-responsive regulatory activity
GD Johnson, A Barrera, IC McDowell, AM D’Ippolito, WH Majoros, ...
Nature Communications 9 (1), 1-9, 2018
Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain
AM Kabadi, PI Thakore, CM Vockley, DG Ousterout, TM Gibson, F Guilak, ...
ACS synthetic biology 4 (6), 689-699, 2015
Decoding the role of regulatory element polymorphisms in complex disease
CM Vockley, A Barrera, TE Reddy
Current Opinion in Genetics & Development 43, 38-45, 2017
Increased genetic diversity and intersubtype recombinants of HIV-1 in blood donors from urban Cameroon
A Machuca, S Tang, J Hu, S Lee, O Wood, C Vockley, SG Vutukuri, ...
JAIDS Journal of Acquired Immune Deficiency Syndromes 45 (3), 361-363, 2007
Many long intergenic non-coding RNAs distally regulate mRNA gene expression levels
I McDowell, A Pai, C Guo, CM Vockley, CD Brown, TE Reddy, ...
bioRxiv, 044719, 2016
A long-range flexible billboard model of gene activation
CM Vockley, IC McDowell, AM D'Ippolito, TE Reddy
Transcription 8 (4), 261-267, 2017
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