| The resurgence of covalent drugs J Singh, RC Petter, TA Baillie, A Whitty Nature reviews Drug discovery 10 (4), 307-317, 2011 | 1974 | 2011 |
| Small-molecule inhibition of TNF-α MM He, AS Smith, JD Oslob, WM Flanagan, AC Braisted, A Whitty, ... Science 310 (5750), 1022-1025, 2005 | 610 | 2005 |
| The isoniazid-NAD adduct is a slow, tight-binding inhibitor of InhA, the Mycobacterium tuberculosis enoyl reductase: adduct affinity and drug resistance R Rawat, A Whitty, PJ Tonge Proceedings of the National Academy of Sciences 100 (24), 13881-13886, 2003 | 467 | 2003 |
| How proteins bind macrocycles EA Villar, D Beglov, S Chennamadhavuni, JA Porco Jr, D Kozakov, ... Nature chemical biology 10 (9), 723-731, 2014 | 426 | 2014 |
| Structural and functional differences between glycosylated and non-glycosylated forms of human interferon-β (IFN-β) L Runkel, W Meier, RB Pepinsky, M Karpusas, A Whitty, K Kimball, ... Pharmaceutical research 15, 641-649, 1998 | 421 | 1998 |
| The immunological synapse and CD28-CD80 interactions SK Bromley, A Iaboni, SJ Davis, A Whitty, JM Green, AS Shaw, A Weiss, ... Nature immunology 2 (12), 1159-1166, 2001 | 417 | 2001 |
| Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins M Sanicola, C Hession, D Worley, P Carmillo, C Ehrenfels, L Walus, ... Proceedings of the National Academy of Sciences 94 (12), 6238-6243, 1997 | 372 | 1997 |
| Cooperativity and biological complexity A Whitty Nature chemical biology 4 (8), 435-439, 2008 | 336 | 2008 |
| Structural conservation of druggable hot spots in protein–protein interfaces D Kozakov, DR Hall, GY Chuang, R Cencic, R Brenke, LE Grove, ... Proceedings of the National Academy of Sciences 108 (33), 13528-13533, 2011 | 281 | 2011 |
| Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs A Whitty, M Zhong, L Viarengo, D Beglov, DR Hall, S Vajda Drug Discovery Today 21 (5), 712-717, 2016 | 253 | 2016 |
| Between a rock and a hard place? A Whitty, G Kumaravel Nature chemical biology 2 (3), 112-118, 2006 | 230 | 2006 |
| Selectivity of BAFF/BLyS and APRIL for binding to the TNF family receptors BAFFR/BR3 and BCMA ES Day, TG Cachero, F Qian, Y Sun, D Wen, M Pelletier, YM Hsu, A Whitty Biochemistry 44 (6), 1919-1931, 2005 | 216 | 2005 |
| Structure-based design of a potent, selective, and irreversible inhibitor of the catalytic domain of the erbB receptor subfamily of protein tyrosine kinases J Singh, EM Dobrusin, DW Fry, T Haske, A Whitty, DJ McNamara Journal of medicinal chemistry 40 (7), 1130-1135, 1997 | 210 | 1997 |
| The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions MR Arkin, A Whitty Current opinion in chemical biology 13 (3), 284-290, 2009 | 208 | 2009 |
| Enhanced potency of human Sonic hedgehog by hydrophobic modification FR Taylor, D Wen, EA Garber, AN Carmillo, DP Baker, RM Arduini, ... Biochemistry 40 (14), 4359-4371, 2001 | 208 | 2001 |
| N-terminally PEGylated human interferon-β-1a with improved pharmacokinetic properties and in vivo efficacy in a melanoma angiogenesis model DP Baker, EY Lin, KC Lin, M Pellegrini, RC Petter, LL Chen, RM Arduini, ... Bioconjugate chemistry 17 (1), 179-188, 2006 | 196 | 2006 |
| Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-β N Di Clemente, SP Jamin, A Lugovskoy, P Carmillo, C Ehrenfels, ... Molecular endocrinology 24 (11), 2193-2206, 2010 | 182 | 2010 |
| The structure of human interferon-β: implications for activity M Karpusas, A Whitty, L Runkel, P Hochman Cellular and Molecular Life Sciences CMLS 54, 1203-1216, 1998 | 170 | 1998 |
| Cryptic binding sites on proteins: definition, detection, and druggability S Vajda, D Beglov, AE Wakefield, M Egbert, A Whitty Current opinion in chemical biology 44, 1-8, 2018 | 152 | 2018 |
| A study of the reactivity of S (VI)–F containing warheads with nucleophilic amino-acid side chains under physiological conditions H Mukherjee, J Debreczeni, J Breed, S Tentarelli, B Aquila, JE Dowling, ... Organic & biomolecular chemistry 15 (45), 9685-9695, 2017 | 141 | 2017 |
