Wolfgang Knecht
Wolfgang Knecht
Senior Lecturer & Manager Lund Protein Production Platform (LP3), Department of Biology, Lund
Verified email at - Homepage
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Structural basis for substrate specificities of cellular deoxyribonucleoside kinases
K Johansson, S Ramaswamy, C Ljungcrantz, W Knecht, J Piškur, ...
Nature structural biology 8 (7), 616-620, 2001
Horizontal gene transfer promoted evolution of the ability to propagate under anaerobic conditions in yeasts
Z Gojković, W Knecht, E Zameitat, J Warneboldt, JB Coutelis, Y Pynyaha, ...
Molecular Genetics and Genomics 271, 387-393, 2004
Requirements for the mitochondrial import and localization of dihydroorotate dehydrogenase
J Rawls, W Knecht, K Diekert, R Lill, M Löffler
European Journal of Biochemistry 267 (7), 2079-2087, 2000
Trypsin IV or mesotrypsin and p23 cleave protease-activated receptors 1 and 2 to induce inflammation and hyperalgesia
W Knecht, GS Cottrell, S Amadesi, J Mohlin, A Skaregarde, K Gedda, ...
Journal of Biological Chemistry 282 (36), 26089-26100, 2007
Kinetics of inhibition of human and rat dihydroorotate dehydrogenase by atovaquone, lawsone derivatives, brequinar sodium and polyporic acid
W Knecht, J Henseling, M Löffler
Chemico-biological interactions 124 (1), 61-76, 2000
Species-related inhibition of human and rat dihydroorotate dehydrogenase by immunosuppressive isoxazol and cinchoninic acid derivatives
W Knecht, M Löffler
Biochemical pharmacology 56 (9), 1259-1264, 1998
Functional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutants
B Munch-Petersen, W Knecht, C Lenz, L Søndergaard, J Piškur
Journal of Biological Chemistry 275 (9), 6673-6679, 2000
Functional expression of a fragment of human dihydroorotate dehydrogenase by means of the baculovirus expression vector system, and kinetic investigation of the purified …
W Knecht, U Bergjohann, S Gonski, B Kirschbaum, M Lóffler
European journal of biochemistry 240 (1), 292-301, 1996
Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents
AD Olmstead, W Knecht, I Lazarov, SB Dixit, F Jean
PLoS pathogens 8 (1), e1002468, 2012
A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines
W Knecht, MPB Sandrini, K Johansson, H Eklund, B Munch-Petersen, ...
The EMBO journal 21 (7), 1873-1880, 2002
Expression, purification, and characterization of histidine-tagged rat and human flavoenzyme dihydroorotate dehydrogenase
B Bader, W Knecht, M Fries, M Löffler
Protein expression and purification 13 (3), 414-422, 1998
Recombinant expression of N‐terminal truncated mutants of the membrane bound mouse, rat and human flavoenzyme dihydroorotate dehydrogenase: A versatile tool to rate inhibitor …
A Ullrich, W Knecht, M Fries, M Löffler
European Journal of Biochemistry 268 (6), 1861-1868, 2001
Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis
GS Cottrell, S Amadesi, S Pikios, E Camerer, JA Willardsen, BR Murphy, ...
Gastroenterology 132 (7), 2422-2437, 2007
Identification of residues involved in the specificity and regulation of the highly efficient multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster
W Knecht, B Munch-Petersen, J Piškur
Journal of molecular biology 301 (4), 827-837, 2000
Application of optical biosensors in small-molecule screening activities
S Geschwindner, JF Carlsson, W Knecht
Sensors 12 (4), 4311-4323, 2012
Deoxyribonucleoside kinases belonging to the thymidine kinase 2 (TK2)-like group vary significantly in substrate specificity, kinetics and feed-back regulation
W Knecht, GE Petersen, B Munch-Petersen, J Piškur
Journal of molecular biology 315 (4), 529-540, 2002
Limited mutagenesis increases the stability of human carboxypeptidase U (TAFIa) and demonstrates the importance of CPU stability over proCPU concentration in down‐regulating …
W Knecht, J Willemse, H Stenhamre, M Andersson, P Berntsson, ...
The FEBS journal 273 (4), 778-792, 2006
Crystal structure of non-structural protein 10 from severe acute respiratory syndrome coronavirus-2
A Rogstam, M Nyblom, S Christensen, C Sele, VO Talibov, T Lindvall, ...
International journal of molecular sciences 21 (19), 7375, 2020
Creating novel activated factor XI inhibitors through fragment based lead generation and structure aided drug design
O Fjellström, S Akkaya, HG Beisel, PO Eriksson, K Erixon, D Gustafsson, ...
PLoS One 10 (1), e0113705, 2015
Structural basis for feedback inhibition of the deoxyribonucleoside salvage pathway: studies of the Drosophila deoxyribonucleoside kinase
NE Mikkelsen, K Johansson, A Karlsson, W Knecht, G Andersen, J Piškur, ...
Biochemistry 42 (19), 5706-5712, 2003
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