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Arjun S Adhikari
Arjun S Adhikari
Stanford University, Blue River Technology
Verificeret mail på rumiscientific.com
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Molecular tension sensors report forces generated by single integrin molecules in living cells
M Morimatsu, AH Mekhdjian, AS Adhikari, AR Dunn
Nano letters 13 (9), 3985-3989, 2013
2592013
The myosin mesa and the basis of hypercontractility caused by hypertrophic cardiomyopathy mutations
S Nag, DV Trivedi, SS Sarkar, AS Adhikari, MS Sunitha, S Sutton, ...
Nature structural & molecular biology 24 (6), 525-533, 2017
2132017
Mechanical load induces a 100-fold increase in the rate of collagen proteolysis by MMP-1
AS Adhikari, J Chai, AR Dunn
Biophysical Journal 100 (3), 513a, 2011
1542011
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light
DV Trivedi, AS Adhikari, SS Sarkar, KM Ruppel, JA Spudich
Biophysical reviews 10 (1), 27-48, 2018
1522018
Early-onset hypertrophic cardiomyopathy mutations significantly increase the velocity, force, and actin-activated ATPase activity of human β-cardiac myosin
AS Adhikari, KB Kooiker, SS Sarkar, C Liu, D Bernstein, JA Spudich, ...
Cell reports 17 (11), 2857-2864, 2016
962016
A cytoskeletal clutch mediates cellular force transmission in a soft, three-dimensional extracellular matrix
LM Owen, AS Adhikari, M Patel, P Grimmer, N Leijnse, MC Kim, ...
Molecular biology of the cell 28 (14), 1959-1974, 2017
882017
The hypertrophic cardiomyopathy mutations R403Q and R663H increase the number of myosin heads available to interact with actin
SS Sarkar, DV Trivedi, MM Morck, AS Adhikari, SN Pasha, KM Ruppel, ...
Science advances 6 (14), eaax0069, 2020
862020
Effects of hypertrophic and dilated cardiomyopathy mutations on power output by human β-cardiac myosin
JA Spudich, T Aksel, SR Bartholomew, S Nag, M Kawana, EC Yu, ...
Journal of Experimental Biology 219 (2), 161-167, 2016
792016
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
AS Adhikari, DV Trivedi, SS Sarkar, D Song, KB Kooiker, D Bernstein, ...
Nature communications 10 (1), 1-10, 2019
782019
Mechanical coordination in motor ensembles revealed using engineered artificial myosin filaments
RF Hariadi, RF Sommese, AS Adhikari, RE Taylor, S Sutton, JA Spudich, ...
Nature nanotechnology 10 (8), 696-700, 2015
762015
Conformational dynamics accompanying the proteolytic degradation of trimeric collagen I by collagenases
AS Adhikari, E Glassey, AR Dunn
Journal of the American Chemical Society 134 (32), 13259-13265, 2012
682012
Myosin motor domains carrying mutations implicated in early or late onset hypertrophic cardiomyopathy have similar properties
CD Vera, CA Johnson, J Walklate, A Adhikari, M Svicevic, SM Mijailovich, ...
Journal of Biological Chemistry 294 (46), 17451-17462, 2019
372019
Strain tunes proteolytic degradation and diffusive transport in fibrin networks
A Adhikari, A Mekhdjian, A Dunn
Biophysical Journal 102 (3), 274a, 2012
282012
pH-dependent formation of lipid heterogeneities controls surface topography and binding reactivity in functionalized bilayers
GB Kempegowda, S Karve, A Bandekar, A Adhikari, T Khaimchayev, ...
Langmuir 25 (14), 8144-8151, 2009
282009
Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington’s disease models
JJ Metzger, C Pereda, A Adhikari, T Haremaki, S Galgoczi, ED Siggia, ...
Cell Reports Methods 2 (9), 2022
222022
Multiplexed Single-molecule Force Proteolysis Measurements Using Magnetic Tweezers
AS Adhikari, J Chai, AR Dunn
Journal of Visualized Experiments 65 (e3520), 2012
62012
Hypertrophic cardiomyopathy and the myosin mesa: viewing an old disease in a new light. Biophys Rev 10: 27–48
DV Trivedi, AS Adhikari, SS Sarkar, KM Ruppel, JA Spudich
52018
The molecular basis of hypercontractility caused by the hypertrophic cardiomyopathy mutations R403Q and R663H
SS Sarkar, DV Trivedi, MM Morck, AS Adhikari, SN Pasha, KM Ruppel, ...
bioRxiv, 543413, 2019
42019
Actomyosin Dynamics in 3D Traction Force Generation
LM Owen, AS Adhikari, MC Kim, N Leijnse, AR Dunn
Biophysical Journal 108 (2), 180a, 2015
12015
β-Cardiac myosin hypertrophic cardiomyopathy mutations release sequestered heads and increase enzymatic activity
AS Adhikari, DV Trivedi, SS Sarkar, D Song, KB Kooiker, D Bernstein, ...
Nature communications 10 (1), 1-10, 2019
2019
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