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Darryl B McConnell
Darryl B McConnell
Boehringer Ingelheim
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Title
Cited by
Cited by
Year
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
W Farnaby, M Koegl, MJ Roy, C Whitworth, E Diers, N Trainor, D Zollman, ...
Nature chemical biology 15 (7), 672-680, 2019
3922019
Drugging an undruggable pocket on KRAS
D Kessler, M Gmachl, A Mantoulidis, LJ Martin, A Zoephel, M Mayer, ...
Proceedings of the National Academy of Sciences 116 (32), 15823-15829, 2019
3492019
BI-3406, a potent and selective SOS1–KRAS interaction inhibitor, is effective in KRAS-driven cancers through combined MEK inhibition
MH Hofmann, M Gmachl, J Ramharter, F Savarese, D Gerlach, ...
Cancer Discovery 11 (1), 142-157, 2021
2832021
Structure-based design of an in vivo active selective BRD9 inhibitor
LJ Martin, M Koegl, G Bader, XL Cockcroft, O Fedorov, D Fiegen, ...
Journal of medicinal chemistry 59 (10), 4462-4475, 2016
2062016
Sensitivity and engineered resistance of myeloid leukemia cells to BRD9 inhibition
AF Hohmann, LJ Martin, JL Minder, JS Roe, J Shi, S Steurer, G Bader, ...
Nature chemical biology 12 (9), 672-679, 2016
1612016
Chemically induced degradation of the oncogenic transcription factor BCL6
N Kerres, S Steurer, S Schlager, G Bader, H Berger, M Caligiuri, C Dank, ...
Cell reports 20 (12), 2860-2875, 2017
1572017
Dimeric zanamivir conjugates with various linking groups are potent, long-lasting inhibitors of influenza neuraminidase including H5N1 avian influenza
SJF Macdonald, R Cameron, DA Demaine, RJ Fenton, G Foster, D Gower, ...
Journal of medicinal chemistry 48 (8), 2964-2971, 2005
1282005
Highly selective PTK2 proteolysis targeting chimeras to probe focal adhesion kinase scaffolding functions
J Popow, H Arnhof, G Bader, H Berger, A Ciulli, D Covini, C Dank, ...
Journal of Medicinal Chemistry 62 (5), 2508-2520, 2019
1182019
Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen
SJF Macdonald, KG Watson, R Cameron, DK Chalmers, DA Demaine, ...
Antimicrobial agents and chemotherapy 48 (12), 4542-4549, 2004
1172004
Discovery of Novel Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction
A Gollner, D Rudolph, H Arnhof, M Bauer, SM Blake, G Boehmelt, ...
Journal of medicinal chemistry 59 (22), 10147-10162, 2016
1082016
Start selective and rigidify: the discovery path toward a next generation of EGFR tyrosine kinase inhibitors
H Engelhardt, D Böse, M Petronczki, D Scharn, G Bader, A Baum, ...
Journal of medicinal chemistry 62 (22), 10272-10293, 2019
1042019
2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binder
RN Brown, R Cameron, DK Chalmers, S Hamilton, A Luttick, GY Krippner, ...
Bioorganic & medicinal chemistry letters 15 (8), 2051-2055, 2005
862005
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
D Kim, L Herdeis, D Rudolph, Y Zhao, J Böttcher, A Vides, ...
Nature 619 (7968), 160-166, 2023
852023
Highly potent and long-acting trimeric and tetrameric inhibitors of influenza virus neuraminidase
KG Watson, R Cameron, RJ Fenton, D Gower, S Hamilton, B Jin, ...
Bioorganic & medicinal chemistry letters 14 (6), 1589-1592, 2004
832004
Fragment-based discovery of a chemical probe for the PWWP1 domain of NSD3
J Böttcher, D Dilworth, U Reiser, RA Neumüller, M Schleicher, ...
Nature chemical biology 15 (8), 822-829, 2019
742019
Microwave-assisted parallel synthesis of fused heterocycles in a novel parallel multimode reactor
M Treu, T Karner, R Kousek, H Berger, M Mayer, DB McConnell, A Stadler
Journal of Combinatorial Chemistry 10 (6), 863-868, 2008
722008
An orally bioavailable oxime ether capsid binder with potent activity against human rhinovirus
KG Watson, RN Brown, R Cameron, DK Chalmers, S Hamilton, B Jin, ...
Journal of medicinal chemistry 46 (15), 3181-3184, 2003
662003
Targeting son of sevenless 1: the pacemaker of KRAS
D Kessler, D Gerlach, N Kraut, DB McConnell
Current Opinion in Chemical Biology 62, 109-118, 2021
612021
Intracellular Trapping of the Selective Phosphoglycerate Dehydrogenase (PHGDH) Inhibitor BI-4924 Disrupts Serine Biosynthesis
H Weinstabl, M Treu, J Rinnenthal, SK Zahn, P Ettmayer, G Bader, ...
Journal of Medicinal Chemistry 62 (17), 7976-7997, 2019
492019
Drugging all RAS isoforms with one pocket
D Kessler, A Bergner, J Böttcher, G Fischer, S Döbel, M Hinkel, ...
Future medicinal chemistry 12 (21), 1911-1923, 2020
482020
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