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Peter Seth Kutchukian
Peter Seth Kutchukian
Novartis Institutes for BioMedical Research (NIBR)
Verified email at novartis.com - Homepage
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Cited by
Cited by
Year
Reaction of superoxide and nitric oxide with peroxynitrite: implications for peroxynitrite-mediated oxidation REACTIONSIN VIVO
D Jourd'heuil, FL Jourd'heuil, PS Kutchukian, RA Musah, DA Wink, ...
Journal of Biological Chemistry 276 (31), 28799-28805, 2001
2672001
Structure of the stapled p53 peptide bound to Mdm2
S Baek, PS Kutchukian, GL Verdine, R Huber, TA Holak, KW Lee, ...
Journal of the American Chemical Society 134 (1), 103-106, 2012
2592012
Rethinking molecular similarity: comparing compounds on the basis of biological activity
PM Petrone, B Simms, F Nigsch, E Lounkine, P Kutchukian, A Cornett, ...
ACS chemical biology 7 (8), 1399-1409, 2012
1472012
Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods
PS Kutchukian, JF Dropinski, KD Dykstra, B Li, DA DiRocco, ...
Chemical science 7 (4), 2604-2613, 2016
1452016
Stitched α-helical peptides via bis ring-closing metathesis
GJ Hilinski, YW Kim, J Hong, PS Kutchukian, CM Crenshaw, ...
Journal of the American Chemical Society 136 (35), 12314-12322, 2014
1422014
Introduction of All-Hydrocarbon i,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis
YW Kim, PS Kutchukian, GL Verdine
Organic letters 12 (13), 3046-3049, 2010
1312010
All-atom model for stabilization of α-helical structure in peptides by hydrocarbon staples
PS Kutchukian, JS Yang, GL Verdine, EI Shakhnovich
Journal of the American Chemical Society 131 (13), 4622-4627, 2009
1222009
De novo design: balancing novelty and confined chemical space
PS Kutchukian, EI Shakhnovich
Expert opinion on drug discovery 5 (8), 789-812, 2010
982010
FOG: Fragment Optimized Growth Algorithm for the de Novo Generation of Molecules Occupying Druglike Chemical Space
PS Kutchukian, D Lou, EI Shakhnovich
Journal of chemical information and modeling 49 (7), 1630-1642, 2009
812009
Inside the Mind of a Medicinal Chemist: The Role of Human Bias in Compound Prioritization during Drug Discovery
PS Kutchukian, NY Vasilyeva, J Xu, MK Lindvall, MP Dillon, M Glick, ...
PLOS ONE 7 (11), e48476, 2012
722012
Enforced presentation of an extrahelical guanine to the lesion recognition pocket of human 8-oxoguanine glycosylase, hOGG1
CM Crenshaw, K Nam, K Oo, PS Kutchukian, BR Bowman, M Karplus, ...
Journal of Biological Chemistry 287 (30), 24916-24928, 2012
642012
Biodiversity of small molecules–a new perspective in screening set selection
PM Petrone, AM Wassermann, E Lounkine, P Kutchukian, B Simms, ...
Drug discovery today 18 (13-14), 674-680, 2013
602013
Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench‐Stable Organozinc Reagents
TJ Greshock, KP Moore, RT McClain, A Bellomo, CK Chung, SD Dreher, ...
Angewandte Chemie 128 (44), 13918-13922, 2016
462016
Targeting RNA with small molecules: identification of selective, RNA-binding small molecules occupying drug-like chemical space
NF Rizvi, JP Santa Maria Jr, A Nahvi, J Klappenbach, DJ Klein, PJ Curran, ...
SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (4), 384-396, 2020
452020
Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies
PS Kutchukian, AM Wassermann, MK Lindvall, SK Wright, J Ottl, J Jacob, ...
Journal of biomolecular screening 20 (5), 588-596, 2015
332015
Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2′-OMe RNA-interacting polynucleotide (RIPtide) microarrays
L Gude, SS Berkovitch, WL Santos, PS Kutchukian, AR Pawloski, ...
Journal of Biological Chemistry 287 (22), 18843-18853, 2012
312012
Representing high throughput expression profiles via perturbation barcodes reveals compound targets
TM Filzen, PS Kutchukian, JD Hermes, J Li, M Tudor
PLoS computational biology 13 (2), e1005335, 2017
272017
Molecular profiling reveals a common metabolic signature of tissue fibrosis
J Zhang, ES Muise, S Han, PS Kutchukian, P Costet, Y Zhu, Y Kan, ...
Cell Reports Medicine 1 (4), 100056, 2020
232020
Chemotography for multi-target SAR analysis in the context of biological pathways
E Lounkine, P Kutchukian, P Petrone, JW Davies, M Glick
Bioorganic & Medicinal Chemistry 20 (18), 5416-5427, 2012
222012
Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase
JP Santa Maria Jr, Y Park, L Yang, N Murgolo, MD Altman, P Zuck, ...
ACS chemical biology 12 (9), 2448-2456, 2017
192017
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