| Structure of the stapled p53 peptide bound to Mdm2 S Baek, PS Kutchukian, GL Verdine, R Huber, TA Holak, KW Lee, ... Journal of the American Chemical Society 134 (1), 103-106, 2012 | 292 | 2012 |
| Reaction of superoxide and nitric oxide with peroxynitrite: implications for peroxynitrite-mediated oxidation REACTIONSIN VIVO D Jourd'heuil, FL Jourd'heuil, PS Kutchukian, RA Musah, DA Wink, ... Journal of Biological Chemistry 276 (31), 28799-28805, 2001 | 284 | 2001 |
| Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods PS Kutchukian, JF Dropinski, KD Dykstra, B Li, DA DiRocco, ... Chemical science 7 (4), 2604-2613, 2016 | 187 | 2016 |
| Stitched α-helical peptides via bis ring-closing metathesis GJ Hilinski, YW Kim, J Hong, PS Kutchukian, CM Crenshaw, ... Journal of the American Chemical Society 136 (35), 12314-12322, 2014 | 174 | 2014 |
| Rethinking molecular similarity: comparing compounds on the basis of biological activity PM Petrone, B Simms, F Nigsch, E Lounkine, P Kutchukian, A Cornett, ... ACS chemical biology 7 (8), 1399-1409, 2012 | 163 | 2012 |
| Introduction of All-Hydrocarbon i,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis YW Kim, PS Kutchukian, GL Verdine Organic letters 12 (13), 3046-3049, 2010 | 141 | 2010 |
| All-atom model for stabilization of α-helical structure in peptides by hydrocarbon staples PS Kutchukian, JS Yang, GL Verdine, EI Shakhnovich Journal of the American Chemical Society 131 (13), 4622-4627, 2009 | 135 | 2009 |
| De novo design: balancing novelty and confined chemical space PS Kutchukian, EI Shakhnovich Expert opinion on drug discovery 5 (8), 789-812, 2010 | 111 | 2010 |
| Inside the Mind of a Medicinal Chemist: The Role of Human Bias in Compound Prioritization during Drug Discovery PS Kutchukian, NY Vasilyeva, J Xu, MK Lindvall, MP Dillon, M Glick, ... PLOS ONE 7 (11), e48476, 2012 | 89 | 2012 |
| FOG: Fragment Optimized Growth Algorithm for the de Novo Generation of Molecules Occupying Druglike Chemical Space PS Kutchukian, D Lou, EI Shakhnovich Journal of chemical information and modeling 49 (7), 1630-1642, 2009 | 89 | 2009 |
| Targeting RNA with small molecules: identification of selective, RNA-binding small molecules occupying drug-like chemical space NF Rizvi, JP Santa Maria Jr, A Nahvi, J Klappenbach, DJ Klein, PJ Curran, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (4), 384-396, 2020 | 69 | 2020 |
| Enforced presentation of an extrahelical guanine to the lesion recognition pocket of human 8-oxoguanine glycosylase, hOGG1 CM Crenshaw, K Nam, K Oo, PS Kutchukian, BR Bowman, M Karplus, ... Journal of Biological Chemistry 287 (30), 24916-24928, 2012 | 67 | 2012 |
| Biodiversity of small molecules–a new perspective in screening set selection PM Petrone, AM Wassermann, E Lounkine, P Kutchukian, B Simms, ... Drug discovery today 18 (13-14), 674-680, 2013 | 63 | 2013 |
| Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench‐Stable Organozinc Reagents TJ Greshock, KP Moore, RT McClain, A Bellomo, CK Chung, SD Dreher, ... Angewandte Chemie 128 (44), 13918-13922, 2016 | 58 | 2016 |
| Large scale meta-analysis of fragment-based screening campaigns: privileged fragments and complementary technologies PS Kutchukian, AM Wassermann, MK Lindvall, SK Wright, J Ottl, J Jacob, ... Journal of biomolecular screening 20 (5), 588-596, 2015 | 36 | 2015 |
| Molecular profiling reveals a common metabolic signature of tissue fibrosis J Zhang, ES Muise, S Han, PS Kutchukian, P Costet, Y Zhu, Y Kan, ... Cell Reports Medicine 1 (4), 2020 | 33 | 2020 |
| Mapping targetable sites on human telomerase RNA pseudoknot/template domain using 2′-OMe RNA-interacting polynucleotide (RIPtide) microarrays L Gude, SS Berkovitch, WL Santos, PS Kutchukian, AR Pawloski, ... Journal of Biological Chemistry 287 (22), 18843-18853, 2012 | 31 | 2012 |
| Representing high throughput expression profiles via perturbation barcodes reveals compound targets TM Filzen, PS Kutchukian, JD Hermes, J Li, M Tudor PLoS computational biology 13 (2), e1005335, 2017 | 28 | 2017 |
| Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase JP Santa Maria Jr, Y Park, L Yang, N Murgolo, MD Altman, P Zuck, ... ACS chemical biology 12 (9), 2448-2456, 2017 | 25 | 2017 |
| Chemotography for multi-target SAR analysis in the context of biological pathways E Lounkine, P Kutchukian, P Petrone, JW Davies, M Glick Bioorganic & Medicinal Chemistry 20 (18), 5416-5427, 2012 | 22 | 2012 |
Meir GlickDirector, Structural Chemistry, Merck & CoVerified email at merck.com
