David Solit
David Solit
Director, Kravis Center for Molecular Oncology, Memorial Sloan Kettering Cancer Center
Verified email at mskcc.org - Homepage
Title
Cited by
Cited by
Year
Comprehensive molecular characterization of human colon and rectal cancer
Cancer Genome Atlas Network
Nature 487 (7407), 330, 2012
47722012
mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt
KE O'Reilly, F Rojo, QB She, D Solit, GB Mills, D Smith, H Lane, ...
Cancer research 66 (3), 1500-1508, 2006
25752006
Comprehensive molecular characterization of urothelial bladder carcinoma
Cancer Genome Atlas Research Network
Nature 507 (7492), 315-322, 2014
17242014
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
R Straussman, T Morikawa, K Shee, M Barzily-Rokni, ZR Qian, J Du, ...
Nature 487 (7408), 500-504, 2012
15172012
Emergence of KRAS mutations and acquired resistance to anti-EGFR therapy in colorectal cancer
S Misale, R Yaeger, S Hobor, E Scala, M Janakiraman, D Liska, E Valtorta, ...
Nature 486 (7404), 532-536, 2012
15002012
BRAF mutation predicts sensitivity to MEK inhibition
DB Solit, LA Garraway, CA Pratilas, A Sawai, G Getz, A Basso, Q Ye, ...
Nature 439 (7074), 358-362, 2006
13852006
Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients
A Zehir, R Benayed, RH Shah, A Syed, S Middha, HR Kim, P Srinivasan, ...
Nature medicine 23 (6), 703, 2017
13352017
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF (V600E)
PI Poulikakos, Y Persaud, M Janakiraman, X Kong, C Ng, G Moriceau, ...
Nature 480 (7377), 387-390, 2011
13052011
Tumor mutational load predicts survival after immunotherapy across multiple cancer types
RM Samstein, CH Lee, AN Shoushtari, MD Hellmann, R Shen, ...
Nature genetics 51 (2), 202-206, 2019
7872019
Inherited DNA-repair gene mutations in men with metastatic prostate cancer
CC Pritchard, J Mateo, MF Walsh, N De Sarkar, W Abida, H Beltran, ...
N Engl J Med 375, 443-453, 2016
7612016
Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function
AD Basso, DB Solit, G Chiosis, B Giri, P Tsichlis, N Rosen
Journal of Biological Chemistry 277 (42), 39858-39866, 2002
6872002
Genome sequencing identifies a basis for everolimus sensitivity
G Iyer, AJ Hanrahan, MI Milowsky, H Al-Ahmadie, SN Scott, ...
Science 338 (6104), 221-221, 2012
6282012
OncoKB: a precision oncology knowledge base
D Chakravarty, J Gao, S Phillips, R Kundra, H Zhang, J Wang, ...
JCO precision oncology 1, 1-16, 2017
5992017
Molecular determinants of response to anti–programmed cell death (PD)-1 and anti–programmed death-ligand 1 (PD-L1) blockade in patients with non–small-cell lung cancer profiled …
H Rizvi, F Sanchez-Vega, K La, W Chatila, P Jonsson, D Halpenny, ...
Journal of Clinical Oncology 36 (7), 633, 2018
5492018
Mutational profile of advanced primary and metastatic radioactive iodine-refractory thyroid cancers reveals distinct pathogenetic roles for BRAF, PIK3CA, and AKT1
JC Ricarte-Filho, M Ryder, DA Chitale, M Rivera, A Heguy, M Ladanyi, ...
Cancer research 69 (11), 4885-4893, 2009
5212009
V600EBRAF is associated with disabled feedback inhibition of RAF–MEK signaling and elevated transcriptional output of the pathway
CA Pratilas, BS Taylor, Q Ye, A Viale, C Sander, DB Solit, N Rosen
Proceedings of the National Academy of Sciences 106 (11), 4519-4524, 2009
5042009
17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts
DB Solit, FF Zheng, M Drobnjak, PN Münster, B Higgins, D Verbel, ...
Clinical cancer research 8 (5), 986-993, 2002
5042002
Tumor adaptation and resistance to RAF inhibitors
P Lito, N Rosen, DB Solit
Nature medicine 19 (11), 1401-1409, 2013
4922013
The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
EW Joseph, CA Pratilas, PI Poulikakos, M Tadi, W Wang, BS Taylor, ...
Proceedings of the National Academy of Sciences 107 (33), 14903-14908, 2010
4482010
The BAD protein integrates survival signaling by EGFR/MAPK and PI3K/Akt kinase pathways in PTEN-deficient tumor cells
QB She, DB Solit, Q Ye, KE O’Reilly, J Lobo, N Rosen
Cancer cell 8 (4), 287-297, 2005
4222005
The system can't perform the operation now. Try again later.
Articles 1–20