Serena Rinaldo
Serena Rinaldo
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NO sensing in Pseudomonas aeruginosa: structure of the transcriptional regulator DNR
G Giardina, S Rinaldo, KA Johnson, A Di Matteo, M Brunori, F Cutruzzolà
Journal of molecular biology 378 (5), 1002-1015, 2008
SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation
A Paone, M Marani, A Fiascarelli, S Rinaldo, G Giardina, R Contestabile, ...
Cell death & disease 5 (11), e1525-e1525, 2014
The immunosuppressive drug azathioprine inhibits biosynthesis of the bacterial signal molecule cyclic-di-GMP by interfering with intracellular nucleotide pool availability
D Antoniani, E Rossi, S Rinaldo, P Bocci, M Lolicato, A Paiardini, ...
Applied microbiology and biotechnology 97 (16), 7325-7336, 2013
The transcription factor DNR from Pseudomonas aeruginosa specifically requires nitric oxide and haem for the activation of a target promoter in Escherichia coli
N Castiglione, S Rinaldo, G Giardina, F Cutruzzola
Microbiology 155 (9), 2838-2844, 2009
Nitrite and nitrite reductases: from molecular mechanisms to significance in human health and disease
N Castiglione, S Rinaldo, G Giardina, V Stelitano, F Cutruzzolà
Antioxidants & redox signaling 17 (4), 684-716, 2012
Glucose metabolism in the progression of prostate cancer
F Cutruzzolà, G Giardina, M Marani, A Macone, A Paiardini, S Rinaldo, ...
Frontiers in physiology 8, 97, 2017
In silico and in vitro validation of serine hydroxymethyltransferase as a chemotherapeutic target of the antifolate drug pemetrexed
F Daidone, R Florio, S Rinaldo, R Contestabile, ML di Salvo, F Cutruzzolà, ...
European journal of medicinal chemistry 46 (5), 1616-1621, 2011
C-di-GMP hydrolysis by Pseudomonas aeruginosa HD-GYP phosphodiesterases: analysis of the reaction mechanism and novel roles for pGpG
V Stelitano, G Giardina, A Paiardini, N Castiglione, F Cutruzzolà, ...
PLoS One 8 (9), e74920, 2013
How pyridoxal 5′‐phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state
G Giardina, P Brunotti, A Fiascarelli, A Cicalini, MGS Costa, AM Buckle, ...
The FEBS journal 282 (7), 1225-1241, 2015
Fast Dissociation of Nitric Oxide from Ferrous Pseudomonas aeruginosa cd1 Nitrite Reductase A NOVEL OUTLOOK ON THE CATALYTIC MECHANISM
S Rinaldo, A Arcovito, M Brunori, F Cutruzzolà
Journal of Biological Chemistry 282 (20), 14761-14767, 2007
Probing the activity of diguanylate cyclases and c-di-GMP phosphodiesterases in real-time by CD spectroscopy
V Stelitano, A Brandt, S Fernicola, S Franceschini, G Giardina, A Pica, ...
Nucleic acids research 41 (7), e79-e79, 2013
Nitrite reductases in denitrification
S Rinaldo, F Cutruzzolà
Biology of the nitrogen cycle, 37-55, 2007
A dramatic conformational rearrangement is necessary for the activation of DNR from Pseudomonas aeruginosa. Crystal structure of wild‐type DNR
G Giardina, S Rinaldo, N Castiglione, M Caruso, F Cutruzzola
Proteins: Structure, Function, and Bioinformatics 77 (1), 174-180, 2009
A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells
M Marani, A Paone, A Fiascarelli, A Macone, M Gargano, S Rinaldo, ...
Oncotarget 7 (4), 4570, 2016
Investigating the allosteric regulation of YfiN from Pseudomonas aeruginosa: clues from the structure of the catalytic domain
G Giardina, A Paiardini, S Fernicola, S Franceschini, S Rinaldo, ...
PloS one 8 (11), e81324, 2013
In silico discovery and in vitro validation of catechol-containing sulfonohydrazide compounds as potent inhibitors of the diguanylate cyclase PleD
S Fernicola, A Paiardini, G Giardina, G Rampioni, L Leoni, F Cutruzzolà, ...
Journal of bacteriology 198 (1), 147-156, 2016
Structural basis of functional diversification of the HD-GYP domain revealed by the Pseudomonas aeruginosa PA4781 protein, which displays an unselective bimetallic binding site
S Rinaldo, A Paiardini, V Stelitano, P Brunotti, L Cervoni, S Fernicola, ...
Journal of bacteriology 197 (8), 1525-1535, 2015
The Pseudomonas aeruginosa DNR transcription factor: light and shade of nitric oxide-sensing mechanisms
G Giardina, N Castiglione, M Caruso, F Cutruzzola, S Rinaldo
Biochemical Society Transactions 39 (1), 294-298, 2011
Screening and in vitro testing of antifolate inhibitors of human cytosolic serine hydroxymethyltransferase
A Paiardini, A Fiascarelli, S Rinaldo, F Daidone, G Giardina, DR Koes, ...
ChemMedChem 10 (3), 490-497, 2015
Intramolecular electron transfer in Pseudomonas aeruginosa cd1 nitrite reductase: thermodynamics and kinetics
O Farver, M Brunori, F Cutruzzolà, S Rinaldo, S Wherland, I Pecht
Biophysical journal 96 (7), 2849-2856, 2009
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