Frédérick Raphaël
Frédérick Raphaël
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Reversal of tumoral immune resistance by inhibition of tryptophan 2, 3-dioxygenase
L Pilotte, P Larrieu, V Stroobant, D Colau, E Dolušić, R Frédérick, ...
Proceedings of the National Academy of Sciences 109 (7), 2497-2502, 2012
Tryptophan 2, 3-dioxygenase (TDO) inhibitors. 3-(2-(pyridyl) ethenyl) indoles as potential anticancer immunomodulators
E Dolušić, P Larrieu, L Moineaux, V Stroobant, L Pilotte, D Colau, ...
Journal of medicinal chemistry 54 (15), 5320-5334, 2011
Coumarin and isocoumarin as serine protease inhibitors
L Pochet, R Frédérick, B Masereel
Current pharmaceutical design 10 (30), 3781-3796, 2004
Synthesis and biological evaluation of novel analogues of the pan class I phosphatidylinositol 3-kinase (PI3K) inhibitor 2-(difluoromethyl)-1-[4, 6-di (4-morpholinyl)-1, 3, 5 …
GW Rewcastle, SA Gamage, JU Flanagan, R Frederick, WA Denny, ...
Journal of medicinal chemistry 54 (20), 7105-7126, 2011
Synthesis and evaluation of β-carboline derivatives as potential monoamine oxidase inhibitors
J Reniers, S Robert, R Frederick, B Masereel, S Vincent, J Wouters
Bioorganic & medicinal chemistry 19 (1), 134-144, 2011
Discovery and preliminary SARs of keto-indoles as novel indoleamine 2, 3-dioxygenase (IDO) inhibitors
E Dolušić, P Larrieu, S Blanc, F Sapunaric, J Pouyez, L Moineaux, ...
European journal of medicinal chemistry 46 (7), 3058-3065, 2011
3, 6-Disubstituted coumarins as mechanism-based inhibitors of thrombin and factor Xa
R Frédérick, S Robert, C Charlier, J de Ruyck, J Wouters, B Pirotte, ...
Journal of medicinal chemistry 48 (24), 7592-7603, 2005
Novel trisubstituted harmine derivatives with original in vitro anticancer activity
R Frédérick, C Bruyère, C Vancraeynest, J Reniers, C Meinguet, L Pochet, ...
Journal of medicinal chemistry 55 (14), 6489-6501, 2012
Lactate dehydrogenase B controls lysosome activity and autophagy in cancer
L Brisson, P Bański, M Sboarina, C Dethier, P Danhier, MJ Fontenille, ...
Cancer Cell 30 (3), 418-431, 2016
Synthesis, biological evaluation and molecular modelling of sulfonohydrazides as selective PI3K p110α inhibitors
JD Kendall, GW Rewcastle, R Frederick, C Mawson, WA Denny, ...
Bioorganic & medicinal chemistry 15 (24), 7677-7687, 2007
Indoleamine 2, 3-dioxygenase inhibitors: a patent review (2008–2012)
E Dolušić, R Frédérick
Expert opinion on therapeutic patents 23 (10), 1367-1381, 2013
New selective carbonic anhydrase IX inhibitors: synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides
T Rogez-Florent, S Meignan, C Foulon, P Six, A Gros, C Bal-Mahieu, ...
Bioorganic & medicinal chemistry 21 (6), 1451-1464, 2013
Modulators of the coagulation cascade: focus and recent advances in inhibitors of tissue factor, factor VIIa and their complex
R Frédérick, L Pochet, C Charlier, B Masereel
Current medicinal chemistry 12 (4), 397-417, 2005
Computational tools for in silico fragment-based drug design
J Mortier, C Rakers, R Frederick, G Wolber
Current topics in medicinal chemistry 12 (17), 1935-1943, 2012
Novel pyrazolo [1, 5-a] pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR
JD Kendall, AC Giddens, KY Tsang, R Frédérick, ES Marshall, R Singh, ...
Bioorganic & medicinal chemistry 20 (1), 58-68, 2012
Discovery of pyrazolo [1, 5-a] pyridines as p110α-selective PI3 kinase inhibitors
JD Kendall, PD O’Connor, AJ Marshall, R Frédérick, ES Marshall, CL Lill, ...
Bioorganic & medicinal chemistry 20 (1), 69-85, 2012
Mechanism-Based Thrombin Inhibitors:  Design, Synthesis, and Molecular Docking of a New Selective 2-Oxo-2H-1-benzopyran Derivative
R Frédérick, S Robert, C Charlier, J Wouters, B Masereel, L Pochet
Journal of medicinal chemistry 50 (15), 3645-3650, 2007
Synthesis, Structural Reassignment, and Biological Activity of Type B MAO Inhibitors Based on the 5H-Indeno[1,2-c]pyridazin-5-one Core
R Frédérick, W Dumont, F Ooms, L Aschenbach, CJ Van der Schyf, ...
Journal of medicinal chemistry 49 (12), 3743-3747, 2006
Phosphoinositide-3-kinases (PI3Ks): combined comparative modeling and 3D-QSAR to rationalize the inhibition of p110α
R Frédérick, WA Denny
Journal of chemical information and modeling 48 (3), 629-638, 2008
Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket
R Frédérick, C Charlier, S Robert, J Wouters, B Masereel, L Pochet
Bioorganic & medicinal chemistry letters 16 (7), 2017-2021, 2006
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