| Enhanced proteolysis of β-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death MA Leissring, W Farris, AY Chang, DM Walsh, X Wu, X Sun, MP Frosch, ... Neuron 40 (6), 1087-1093, 2003 | 929 | 2003 |
| Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders MP Mattson, FM LaFerla, SL Chan, MA Leissring, PN Shepel, JD Geiger Trends in neurosciences 23 (5), 222-229, 2000 | 615 | 2000 |
| Proteolytic degradation of amyloid β-protein T Saido, MA Leissring Cold Spring Harbor perspectives in medicine 2 (6), a006379, 2012 | 432 | 2012 |
| Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice MA Leissring, Y Akbari, CM Fanger, MD Cahalan, MP Mattson, ... The Journal of cell biology 149 (4), 793-798, 2000 | 425 | 2000 |
| A physiologic signaling role for the γ-secretase-derived intracellular fragment of APP MA Leissring, MP Murphy, TR Mead, Y Akbari, MC Sugarman, ... Proceedings of the National Academy of Sciences 99 (7), 4697-4702, 2002 | 366 | 2002 |
| Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid β-protein W Farris, S Mansourian, MA Leissring, EA Eckman, L Bertram, ... The American journal of pathology 164 (4), 1425-1434, 2004 | 338 | 2004 |
| Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging Z Ahmed, H Sheng, Y Xu, WL Lin, AE Innes, J Gass, X Yu, H Hou, S Chiba, ... The American journal of pathology 177 (1), 311-324, 2010 | 320 | 2010 |
| Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones JP Maianti, A McFedries, ZH Foda, RE Kleiner, XQ Du, MA Leissring, ... Nature 511 (7507), 94-98, 2014 | 268 | 2014 |
| Alzheimer's Presenilin‐1 Mutation Potentiates Inositol 1,4,5‐Trisphosphate‐Mediated Calcium Signaling in Xenopus MA Leissring, BA Paul, I Parker, CW Cotman, FM LaFerla Journal of neurochemistry 72 (3), 1061-1068, 1999 | 240 | 1999 |
| Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy W Farris, SG Schütz, JR Cirrito, GM Shankar, X Sun, A George, ... The American journal of pathology 171 (1), 241-251, 2007 | 207 | 2007 |
| Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria MA Leissring, W Farris, X Wu, DC Christodoulou, MC Haigis, L Guarente, ... Biochemical journal 383 (3), 439-446, 2004 | 202 | 2004 |
| Presenilin-2 mutations modulate amplitude and kinetics of inositol 1, 4, 5-trisphosphate-mediated calcium signals MA Leissring, I Parker, FM LaFerla Journal of Biological Chemistry 274 (46), 32535-32538, 1999 | 183 | 1999 |
| Biochemical and immunohistochemical analysis of an Alzheimer's disease mouse model reveals the presence of multiple cerebral Aβ assembly forms throughout life GM Shankar, MA Leissring, A Adame, X Sun, E Spooner, E Masliah, ... Neurobiology of disease 36 (2), 293-302, 2009 | 150 | 2009 |
| Structure of substrate-free human insulin-degrading enzyme (IDE) and biophysical analysis of ATP-induced conformational switch of IDE H Im, M Manolopoulou, E Malito, Y Shen, J Zhao, M Neant-Fery, CY Sun, ... Journal of biological chemistry 282 (35), 25453-25463, 2007 | 146 | 2007 |
| Kinetics of amyloid β-protein degradation determined by novel fluorescence-and fluorescence polarization-based assays MA Leissring, A Lu, MM Condron, DB Teplow, RL Stein, W Farris, ... Journal of Biological Chemistry 278 (39), 37314-37320, 2003 | 145 | 2003 |
| Inclusion body myositis-like phenotype induced by transgenic overexpression of βAPP in skeletal muscle MC Sugarman, TR Yamasaki, S Oddo, JC Echegoyen, MP Murphy, ... Proceedings of the National Academy of Sciences 99 (9), 6334-6339, 2002 | 138 | 2002 |
| Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin MA Leissring, E Malito, S Hedouin, L Reinstatler, T Sahara, SO Abdul-Hay, ... PloS one 5 (5), e10504, 2010 | 132 | 2010 |
| Deletion of insulin-degrading enzyme elicits antipodal, age-dependent effects on glucose and insulin tolerance SO Abdul-Hay, D Kang, M McBride, L Li, J Zhao, MA Leissring PloS one 6 (6), e20818, 2011 | 127 | 2011 |
| Multiphoton-evoked color change of DsRed as an optical highlighter for cellular and subcellular labeling JS Marchant, GE Stutzmann, MA Leissring, FM LaFerla, I Parker Nature biotechnology 19 (7), 645-649, 2001 | 126 | 2001 |
| Calsenilin reverses presenilin-mediated enhancement of calcium signaling MA Leissring, TR Yamasaki, W Wasco, JD Buxbaum, I Parker, FM LaFerla Proceedings of the National Academy of Sciences 97 (15), 8590-8593, 2000 | 119 | 2000 |
Samer Abdul-HayMayo Clinic - JacksonvilleVerified email at mayo.edu
