| Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients SJ Howe, MR Mansour, K Schwarzwaelder, C Bartholomae, M Hubank, ... The Journal of clinical investigation 118 (9), 2008 | 1440 | 2008 |
| An oncogenic super-enhancer formed through somatic mutation of a noncoding intergenic element MR Mansour, BJ Abraham, L Anders, A Berezovskaya, A Gutierrez, ... Science 346 (6215), 1373-1377, 2014 | 840 | 2014 |
| Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers RS Maser, B Choudhury, PJ Campbell, B Feng, KK Wong, A Protopopov, ... Nature 447 (7147), 966-971, 2007 | 449 | 2007 |
| T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics, and outcome from the large randomized prospective trial (UKALL XII/ECOG 2993) DI Marks, EM Paietta, AV Moorman, SM Richards, G Buck, G DeWald, ... Blood, The Journal of the American Society of Hematology 114 (25), 5136-5145, 2009 | 435 | 2009 |
| Notch signaling: switching an oncogene to a tumor suppressor C Lobry, P Oh, MR Mansour, AT Look, I Aifantis Blood, The Journal of the American Society of Hematology 123 (16), 2451-2459, 2014 | 294 | 2014 |
| Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL WR Gordon, M Roy, D Vardar-Ulu, M Garfinkel, MR Mansour, JC Aster, ... Blood, The Journal of the American Society of Hematology 113 (18), 4381-4390, 2009 | 217 | 2009 |
| KPT‐330 inhibitor of CRM 1 (XPO 1)‐mediated nuclear export has selective anti‐leukaemic activity in preclinical models of T‐cell acute lymphoblastic leukaemia and acute myeloid … J Etchin, T Sanda, MR Mansour, A Kentsis, J Montero, BT Le, AL Christie, ... British journal of haematology 161 (1), 117-127, 2013 | 203 | 2013 |
| Antileukemic activity of nuclear export inhibitors that spare normal hematopoietic cells J Etchin, Q Sun, A Kentsis, A Farmer, ZC Zhang, T Sanda, MR Mansour, ... Leukemia 27 (1), 66-74, 2013 | 202 | 2013 |
| Therapeutic targeting of “undruggable” MYC V Llombart, MR Mansour EBioMedicine 75, 2022 | 178 | 2022 |
| Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress R Burt, A Dey, S Aref, M Aguiar, A Akarca, K Bailey, W Day, S Hooper, ... Blood, The Journal of the American Society of Hematology 134 (17), 1415-1429, 2019 | 170 | 2019 |
| Cyclin C is a haploinsufficient tumour suppressor N Li, A Fassl, J Chick, H Inuzuka, X Li, MR Mansour, L Liu, H Wang, ... Nature cell biology 16 (11), 1080-1091, 2014 | 159 | 2014 |
| WT1 mutations in T-ALL V Tosello, MR Mansour, K Barnes, M Paganin, ML Sulis, S Jenkinson, ... Blood, The Journal of the American Society of Hematology 114 (5), 1038-1045, 2009 | 149 | 2009 |
| Prognostic implications of NOTCH1 and FBXW7 mutations in adults with T-cell acute lymphoblastic leukemia treated on the MRC UKALLXII/ECOG E2993 protocol MR Mansour, ML Sulis, V Duke, L Foroni, S Jenkinson, K Koo, CG Allen, ... Journal of clinical oncology 27 (26), 4352, 2009 | 143 | 2009 |
| The TAL1 complex targets the FBXW7 tumor suppressor by activating miR-223 in human T cell acute lymphoblastic leukemia MR Mansour, T Sanda, LN Lawton, X Li, T Kreslavsky, CD Novina, ... Journal of Experimental Medicine 210 (8), 1545-1557, 2013 | 142 | 2013 |
| Pten mediates Myc oncogene dependence in a conditional zebrafish model of T cell acute lymphoblastic leukemia A Gutierrez, R Grebliunaite, H Feng, E Kozakewich, S Zhu, F Guo, ... Journal of Experimental Medicine 208 (8), 1595-1603, 2011 | 135 | 2011 |
| Activity of a selective inhibitor of nuclear export, selinexor (KPT-330), against AML-initiating cells engrafted into immunosuppressed NSG mice J Etchin, J Montero, A Berezovskaya, BT Le, A Kentsis, AL Christie, ... Leukemia 30 (1), 0-0, 2016 | 93 | 2016 |
| Small genomic insertions form enhancers that misregulate oncogenes BJ Abraham, D Hnisz, AS Weintraub, N Kwiatkowski, CH Li, Z Li, ... Nature communications 8 (1), 14385, 2017 | 92 | 2017 |
| High incidence of Notch-1 mutations in adult patients with T-cell acute lymphoblastic leukemia MR Mansour, DC Linch, L Foroni, AH Goldstone, RE Gale Leukemia 20 (3), 537-539, 2006 | 92 | 2006 |
| Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia MR Mansour, V Duke, L Foroni, B Patel, CG Allen, PJ Ancliff, RE Gale, ... Clinical cancer research 13 (23), 6964-6969, 2007 | 91 | 2007 |
| PI3K/mTOR inhibition upregulates NOTCH-MYC signalling leading to an impaired cytotoxic response C Shepherd, L Banerjee, CW Cheung, MR Mansour, S Jenkinson, ... Leukemia 27 (3), 650-660, 2013 | 89 | 2013 |
