| Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels D Spanswick, MA Smith, VE Groppi, SD Logan, MLJ Ashford Nature 390 (6659), 521-525, 1997 | 812 | 1997 |
| A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization RS Hurst, M Hajós, M Raggenbass, TM Wall, NR Higdon, JA Lawson, ... Journal of Neuroscience 25 (17), 4396-4405, 2005 | 529 | 2005 |
| The selective α7 nicotinic acetylcholine receptor agonist PNU-282987 [N-[(3R)-1-azabicyclo [2.2. 2] oct-3-yl]-4-chlorobenzamide hydrochloride] enhances GABAergic synaptic … M Hajos, RS Hurst, WE Hoffmann, M Krause, TM Wall, NR Higdon, ... Journal of Pharmacology and Experimental Therapeutics 312 (3), 1213-1222, 2005 | 286 | 2005 |
| Discovery and structure− activity relationship of quinuclidine benzamides as agonists of α7 nicotinic acetylcholine receptors AL Bodnar, LA Cortes-Burgos, KK Cook, DM Dinh, VE Groppi, M Hajos, ... Journal of medicinal chemistry 48 (4), 905-908, 2005 | 268 | 2005 |
| Discovery of N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide, an Agonist of the α7 Nicotinic Acetylcholine Receptor, for the Potential … DG Wishka, DP Walker, KM Yates, SC Reitz, S Jia, JK Myers, KL Olson, ... Journal of medicinal chemistry 49 (14), 4425-4436, 2006 | 238 | 2006 |
| The DBA/2J strain and prepulse inhibition of startle: a model system to test antipsychotics? B Olivier, C Leahy, T Mullen, R Paylor, VE Groppi, Z Sarnyai, D Brunner Psychopharmacology 156, 284-290, 2001 | 134 | 2001 |
| Inhibition of protein synthesis stabilizes histone mRNA E Stimac, VE Groppi Jr, P Coffino Molecular and Cellular Biology 4 (10), 2082-2090, 1984 | 130 | 1984 |
| Design, synthesis, structure–activity relationship, and in vivo activity of azabicyclic aryl amides as α7 nicotinic acetylcholine receptor agonists DP Walker, DG Wishka, DW Piotrowski, S Jia, SC Reitz, KM Yates, ... Bioorganic & medicinal chemistry 14 (24), 8219-8248, 2006 | 118 | 2006 |
| G1 and S phase mammalian cells synthesize histones at equivalent rates VE Groppi Jr, P Coffino Cell 21 (1), 195-204, 1980 | 116 | 1980 |
| Discovery of N-[(3R, 5R)-1-azabicyclo [3.2. 1] oct-3-yl] furo [2, 3-c] pyridine-5-carboxamide as an agonist of the α7 nicotinic acetylcholine receptor: In vitro and in vivo … BA Acker, EJ Jacobsen, BN Rogers, DG Wishka, SC Reitz, DW Piotrowski, ... Bioorganic & Medicinal Chemistry Letters 18 (12), 3611-3615, 2008 | 95 | 2008 |
| Synthesis and biological activity of spirocyclic benzopyran imidazolone potassium channel openers RC Gadwood, BV Kamdar, LAC Dubray, ML Wolfe, MP Smith, W Watt, ... Journal of medicinal chemistry 36 (10), 1480-1487, 1993 | 86 | 1993 |
| Altered adenosine cyclic 3', 5'-monophosphate synthesis and degradation by C-6 astrocytoma cells following prolonged exposure to norepinephrine ET BROWNING, CO BROSTROM, VE GROPPI Molecular Pharmacology 12 (1), 32-40, 1976 | 86 | 1976 |
| Resolution of basic cellular proteins including histone variants by two-dimensional gel electrophoresis: evaluation of lysine to arginine ratios and phosphorylation MM Sanders, VE Groppi Jr, ET Browning Analytical Biochemistry 103 (1), 157-165, 1980 | 72 | 1980 |
| Anthelmintic paraherquamides are cholinergic antagonists in gastrointestinal nematodes and mammals EW Zinser, ML Wolf, SJ Alexander‐Bowman, EM Thomas, JP Davis, ... Journal of veterinary pharmacology and therapeutics 25 (4), 241-250, 2002 | 68 | 2002 |
| Quinuclidine-substituted heteroaryl moieties for treatment of disease JK Myers, BN Rogers, VE Groppi Jr, DW Piotrowski, AL Bodnar, ... US Patent 6,492,385, 2002 | 67 | 2002 |
| Quinuclidine-substituted aryl compounds for treatment of disease JK Myers, VE Groppi Jr, DW Piotrowski US Patent 6,486,172, 2002 | 66 | 2002 |
| Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease DP Walker, DW Piotrowski, EJ Jacobsen, BA Acker, DG Wishka, SC Reitz US Patent 6,911,543, 2005 | 63 | 2005 |
| Phenotypic optimization of urea–thiophene carboxamides to yield potent, well tolerated, and orally active protective agents against aminoglycoside-induced hearing loss S Chowdhury, KN Owens, RJ Herr, Q Jiang, X Chen, G Johnson, ... Journal of medicinal chemistry 61 (1), 84-97, 2018 | 57 | 2018 |
| Quinuclidine-substituted heteroaryl moieties for treatment of disease JK Myers, BN Rogers, VE Groppi Jr, DW Piotrowski, AL Bodnar, ... US Patent 6,500,840, 2002 | 56 | 2002 |
| ATP-sensitive K+ channel opener acts as a potent Cl− channel inhibitor in vascular smooth muscle cells KO Holevinsky, Z Fan, M Frame, JC Makielski, V Groppi, DJ Nelson The Journal of membrane biology 137, 59-70, 1994 | 55 | 1994 |
