Chao Lu
Chao Lu
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Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
ME Figueroa, O Abdel-Wahab, C Lu, PS Ward, J Patel, A Shih, Y Li, ...
Cancer cell 18 (6), 553-567, 2010
IDH mutation impairs histone demethylation and results in a block to cell differentiation
C Lu, PS Ward, GS Kapoor, D Rohle, S Turcan, O Abdel-Wahab, ...
Nature, 2012
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
S Turcan, D Rohle, A Goenka, LA Walsh, F Fang, E Yilmaz, C Campos, ...
Nature, 2012
Metabolic Regulation of Epigenetics
C Lu, CB Thompson
Cell Metabolism 16 (1), 9-17, 2012
Hypoxia induces production of L-2-hydroxyglutarate
AM Intlekofer, RG Dematteo, S Venneti, LWS Finley, C Lu, AR Judkins, ...
Cell metabolism 22 (2), 304-311, 2015
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
KE Wellen, C Lu, A Mancuso, JMS Lemons, M Ryczko, JW Dennis, ...
Genes & development 24 (24), 2784-2799, 2010
Serine catabolism regulates mitochondrial redox control during hypoxia
J Ye, J Fan, S Venneti, YW Wan, BR Pawel, J Zhang, LWS Finley, C Lu, ...
Cancer discovery 4 (12), 1406-1417, 2014
The histone mark H3K36me2 recruits DNMT3A and shapes the intergenic DNA methylation landscape
DN Weinberg, S Papillon-Cavanagh, H Chen, Y Yue, X Chen, ...
Nature 573 (7773), 281-286, 2019
Ammonia-induced autophagy is independent of ULK1/ULK2 kinases
H Cheong, T Lindsten, J Wu, C Lu, CB Thompson
Proceedings of the National Academy of Sciences 108 (27), 11121, 2011
Therapeutic targets in cancer cell metabolism and autophagy
H Cheong, C Lu, T Lindsten, CB Thompson
Nature Biotechnology 30 (7), 671-678, 2012
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape
C Lu, SU Jain, D Hoelper, D Bechet, RC Molden, L Ran, D Murphy, ...
Science 352 (6287), 844-849, 2016
DNA hydroxymethylation profiling reveals that WT1 mutations result in loss of TET2 function in acute myeloid leukemia
R Rampal, A Alkalin, J Madzo, A Vasanthakumar, E Pronier, J Patel, Y Li, ...
Cell reports 9 (5), 1841-1855, 2014
H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis
AS Harutyunyan, B Krug, H Chen, S Papillon-Cavanagh, M Zeinieh, ...
Nature communications 10 (1), 1262, 2019
Impaired H3K36 methylation defines a subset of head and neck squamous cell carcinomas
S Papillon-Cavanagh, C Lu, T Gayden, LG Mikael, D Bechet, ...
Nature genetics 49 (2), 180-185, 2017
Cancer-associated IDH2 mutants drive an acute myeloid leukemia that is susceptible to Brd4 inhibition
C Chen, Y Liu, C Lu, JR Cross, JP Morris, AS Shroff, PS Ward, JE Bradner, ...
Genes & Development 27 (18), 1974-1985, 2013
Identification of additional IDH mutations associated with oncometabolite R (−)-2-hydroxyglutarate production
PS Ward, JR Cross, C Lu, O Weigert, O Abel-Wahab, RL Levine, ...
Oncogene, 2011
The Potential for Isocitrate Dehydrogenase Mutations to Produce 2-Hydroxyglutarate Depends on Allele Specificity and Subcellular Compartmentalization
PS Ward, C Lu, JR Cross, O Abdel-Wahab, RL Levine, GK Schwartz, ...
Journal of Biological Chemistry 288 (6), 3804-3815, 2013
Induction of sarcomas by mutant IDH2
C Lu, S Venneti, A Akalin, F Fang, PS Ward, RG DeMatteo, AM Intlekofer, ...
Genes & Development 27 (18), 1986-1998, 2013
Lowered H3K27me3 and DNA hypomethylation define poorly prognostic pediatric posterior fossa ependymomas
J Bayliss, P Mukherjee, C Lu, SU Jain, C Chung, D Martinez, B Sabari, ...
Science translational medicine 8 (366), 366ra161-366ra161, 2016
Functional interrogation of DNA damage response variants with base editing screens
R Cuella-Martin, SB Hayward, X Fan, X Chen, JW Huang, A Taglialatela, ...
Cell 184 (4), 1081-1097. e19, 2021
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