Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding TN Starr, AJ Greaney, SK Hilton, D Ellis, KHD Crawford, AS Dingens, ... cell 182 (5), 1295-1310. e20, 2020 | 1863 | 2020 |
Comprehensive mapping of mutations in the SARS-CoV-2 receptor-binding domain that affect recognition by polyclonal human plasma antibodies AJ Greaney, AN Loes, KHD Crawford, TN Starr, KD Malone, HY Chu, ... Cell host & microbe 29 (3), 463-476. e6, 2021 | 1195 | 2021 |
Complete mapping of mutations to the SARS-CoV-2 spike receptor-binding domain that escape antibody recognition AJ Greaney, TN Starr, P Gilchuk, SJ Zost, E Binshtein, AN Loes, SK Hilton, ... Cell host & microbe 29 (1), 44-57. e9, 2021 | 1048 | 2021 |
Prospective mapping of viral mutations that escape antibodies used to treat COVID-19 TN Starr, AJ Greaney, A Addetia, WW Hannon, MC Choudhary, ... Science 371 (6531), 850-854, 2021 | 739 | 2021 |
Complete map of SARS-CoV-2 RBD mutations that escape the monoclonal antibody LY-CoV555 and its cocktail with LY-CoV016 TN Starr, AJ Greaney, AS Dingens, JD Bloom Cell Reports Medicine 2 (4), 2021 | 469 | 2021 |
SARS-CoV-2 RBD antibodies that maximize breadth and resistance to escape TN Starr, N Czudnochowski, Z Liu, F Zatta, YJ Park, A Addetia, D Pinto, ... Nature 597 (7874), 97-102, 2021 | 379 | 2021 |
Mapping mutations to the SARS-CoV-2 RBD that escape binding by different classes of antibodies AJ Greaney, TN Starr, CO Barnes, Y Weisblum, F Schmidt, M Caskey, ... Nature communications 12 (1), 4196, 2021 | 348 | 2021 |
Genetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail J Dong, SJ Zost, AJ Greaney, TN Starr, AS Dingens, EC Chen, RE Chen, ... Nature microbiology 6 (10), 1233-1244, 2021 | 247 | 2021 |
Antibodies elicited by mRNA-1273 vaccination bind more broadly to the receptor binding domain than do those from SARS-CoV-2 infection AJ Greaney, AN Loes, LE Gentles, KHD Crawford, TN Starr, KD Malone, ... Science translational medicine 13 (600), eabi9915, 2021 | 196 | 2021 |
Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution TN Starr, AJ Greaney, WW Hannon, AN Loes, K Hauser, JR Dillen, E Ferri, ... Science 377 (6604), 420-424, 2022 | 153 | 2022 |
Sulforaphane inhibits multiple inflammasomes through an Nrf2-independent mechanism AJ Greaney, NK Maier, SH Leppla, M Moayeri Journal of Leucocyte Biology 99 (1), 189-199, 2016 | 149 | 2016 |
Elicitation of broadly protective sarbecovirus immunity by receptor-binding domain nanoparticle vaccines AC Walls, MC Miranda, A Schäfer, MN Pham, A Greaney, ... Cell 184 (21), 5432-5447. e16, 2021 | 144 | 2021 |
Mosaic RBD nanoparticles protect against challenge by diverse sarbecoviruses in animal models AA Cohen, N van Doremalen, AJ Greaney, H Andersen, A Sharma, ... Science 377 (6606), eabq0839, 2022 | 134 | 2022 |
ACE2 binding is an ancestral and evolvable trait of sarbecoviruses TN Starr, SK Zepeda, AC Walls, AJ Greaney, S Alkhovsky, D Veesler, ... Nature 603 (7903), 913-918, 2022 | 131 | 2022 |
Genetic and structural basis for recognition of SARS-CoV-2 spike protein by a two-antibody cocktail J Dong, SJ Zost, AJ Greaney, TN Starr, AS Dingens, EC Chen, RE Chen, ... BioRxiv, 2021.01. 27.428529, 2021 | 127 | 2021 |
Bacterial exotoxins and the inflammasome AJ Greaney, SH Leppla, M Moayeri Frontiers in immunology 6, 162956, 2015 | 114 | 2015 |
Deep mutational scans for ACE2 binding, RBD expression, and antibody escape in the SARS-CoV-2 Omicron BA. 1 and BA. 2 receptor-binding domains TN Starr, AJ Greaney, CM Stewart, AC Walls, WW Hannon, D Veesler, ... PLoS pathogens 18 (11), e1010951, 2022 | 100 | 2022 |
The rosetteless gene controls development in the choanoflagellate S. rosetta TC Levin, AJ Greaney, L Wetzel, N King Elife 3, e04070, 2014 | 91 | 2014 |
An antibody-escape estimator for mutations to the SARS-CoV-2 receptor-binding domain AJ Greaney, TN Starr, JD Bloom Virus evolution 8 (1), veac021, 2022 | 76 | 2022 |
Selection analysis identifies clusters of unusual mutational changes in Omicron lineage BA. 1 that likely impact Spike function DP Martin, S Lytras, AG Lucaci, W Maier, B Grüning, SD Shank, S Weaver, ... Molecular Biology and Evolution 39 (4), msac061, 2022 | 67 | 2022 |