Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade N McGranahan, AJS Furness, R Rosenthal, S Ramskov, R Lyngaa, ... Science 351 (6280), 1463-1469, 2016 | 3185 | 2016 |
Tracking the evolution of non–small-cell lung cancer M Jamal-Hanjani, GA Wilson, N McGranahan, NJ Birkbak, TBK Watkins, ... New England Journal of Medicine 376 (22), 2109-2121, 2017 | 2381 | 2017 |
Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution C Abbosh, NJ Birkbak, GA Wilson, M Jamal-Hanjani, T Constantin, ... Nature 545 (7655), 446-451, 2017 | 1842 | 2017 |
Allele-specific HLA loss and immune escape in lung cancer evolution N McGranahan, R Rosenthal, CT Hiley, AJ Rowan, TBK Watkins, ... Cell 171 (6), 1259-1271. e11, 2017 | 1298 | 2017 |
DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution R Rosenthal, N McGranahan, J Herrero, BS Taylor, C Swanton Genome biology 17 (1), 1-11, 2016 | 1117 | 2016 |
Insertion-and-deletion-derived tumour-specific neoantigens and the immunogenic phenotype: a pan-cancer analysis S Turajlic, K Litchfield, H Xu, R Rosenthal, N McGranahan, JL Reading, ... The Lancet Oncology 18 (8), 1009-1021, 2017 | 934 | 2017 |
Neoantigen-directed immune escape in lung cancer evolution R Rosenthal, EL Cadieux, R Salgado, MA Bakir, DA Moore, CT Hiley, ... Nature 567 (7749), 479-485, 2019 | 826 | 2019 |
Meta-analysis of tumor-and T cell-intrinsic mechanisms of sensitization to checkpoint inhibition K Litchfield, JL Reading, C Puttick, K Thakkar, C Abbosh, R Bentham, ... Cell 184 (3), 596-614. e14, 2021 | 704 | 2021 |
Deterministic evolutionary trajectories influence primary tumor growth: TRACERx renal S Turajlic, H Xu, K Litchfield, A Rowan, S Horswell, T Chambers, ... Cell 173 (3), 595-610. e11, 2018 | 621 | 2018 |
Fc effector function contributes to the activity of human anti-CTLA-4 antibodies FA Vargas, AJS Furness, K Litchfield, K Joshi, R Rosenthal, E Ghorani, ... Cancer cell 33 (4), 649-663. e4, 2018 | 595 | 2018 |
Fc-optimized anti-CD25 depletes tumor-infiltrating regulatory T cells and synergizes with PD-1 blockade to eradicate established tumors FA Vargas, AJS Furness, I Solomon, K Joshi, L Mekkaoui, MH Lesko, ... Immunity 46 (4), 577-586, 2017 | 454 | 2017 |
Large-scale detection of antigen-specific T cells using peptide-MHC-I multimers labeled with DNA barcodes AK Bentzen, AM Marquard, R Lyngaa, SK Saini, S Ramskov, M Donia, ... Nature biotechnology 34 (10), 1037-1045, 2016 | 363 | 2016 |
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma K AbdulJabbar, SEA Raza, R Rosenthal, M Jamal-Hanjani, S Veeriah, ... Nature Medicine 26 (7), 1054-1062, 2020 | 263 | 2020 |
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer K Joshi, MR de Massy, M Ismail, JL Reading, I Uddin, A Woolston, ... Nature medicine 25 (10), 1549-1559, 2019 | 181 | 2019 |
Perspective: APOBEC mutagenesis in drug resistance and immune escape in HIV and cancer evolution S Venkatesan, R Rosenthal, N Kanu, N McGranahan, J Bartek, ... Annals of Oncology 29 (3), 563-572, 2018 | 168 | 2018 |
Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma E Ghorani, R Rosenthal, N McGranahan, JL Reading, M Lynch, KS Peggs, ... Annals of Oncology 29 (1), 271-279, 2017 | 138 | 2017 |
A clonal expression biomarker associates with lung cancer mortality D Biswas, NJ Birkbak, R Rosenthal, CT Hiley, EL Lim, K Papp, S Boeing, ... Nature Medicine, 1-9, 2019 | 103 | 2019 |
The T cell differentiation landscape is shaped by tumour mutations in lung cancer E Ghorani, JL Reading, JY Henry, MR Massy, R Rosenthal, V Turati, ... Nature cancer 1 (5), 546-561, 2020 | 95 | 2020 |
Immune surveillance in clinical regression of preinvasive squamous cell lung cancer A Pennycuick, VH Teixeira, K AbdulJabbar, SEA Raza, T Lund, ... Cancer Discovery 10 (10), 1489-1499, 2020 | 84 | 2020 |
Intratumoural evolutionary landscape of high-risk prostate cancer: the PROGENY study of genomic and immune parameters M Linch, G Goh, C Hiley, Y Shanmugabavan, N McGranahan, A Rowan, ... Annals of Oncology 28 (10), 2472-2480, 2017 | 72 | 2017 |