| Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1 DJ Klionsky, AK Abdel-Aziz, S Abdelfatah, M Abdellatif, A Abdoli, S Abel, ... autophagy 17 (1), 1-382, 2021 | 9634 | 2021 |
| Self-inactivating lentiviral vectors with enhanced transgene expression as potential gene transfer system in Parkinson's disease N Deglon, JL Tseng, JC Bensadoun, AD Zurn, Y Arsenijevic, ... Human gene therapy 11 (1), 179-190, 2000 | 347 | 2000 |
| miR‐155 modulates microglia‐mediated immune response by down‐regulating SOCS‐1 and promoting cytokine and nitric oxide production AL Cardoso, JR Guedes, L Pereira de Almeida, MC Pedroso de Lima Immunology 135 (1), 73-88, 2012 | 315 | 2012 |
| Extracellular vesicles: Novel promising delivery systems for therapy of brain diseases D Rufino-Ramos, PR Albuquerque, V Carmona, R Perfeito, RJ Nobre, ... Journal of Controlled Release 262, 247-258, 2017 | 277 | 2017 |
| Lentiviral-Mediated Delivery of Mutant Huntingtin in the Striatum of Rats Induces a Selective Neuropathology Modulated by Polyglutamine Repeat Size, Huntingtin Expression Levels L Pereira de Almeida, CA Ross, D Zala, P Aebischer, N Deglon The Journal of Neuroscience 22 (9), 3473-3483, 2002 | 245 | 2002 |
| Overexpression of the autophagic beclin-1 protein clears mutant ataxin-3 and alleviates Machado–Joseph disease I Nascimento-Ferreira, T Santos-Ferreira, L Sousa-Ferreira, G Auregan, ... Brain 134 (5), 1400-1415, 2011 | 203 | 2011 |
| Gene therapy for the CNS using AAVs: the impact of systemic delivery by AAV9 J Saraiva, RJ Nobre, LP de Almeida Journal of Controlled Release 241, 94-109, 2016 | 195 | 2016 |
| Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease LP de Almeida, D Zala, P Aebischer, N Deglon Neurobiology of disease 8 (3), 433-446, 2001 | 190 | 2001 |
| Allele-specific RNA silencing of mutant ataxin-3 mediates neuroprotection in a rat model of Machado-Joseph disease S Alves, I Nascimento-Ferreira, G Auregan, R Hassig, N Dufour, ... PloS one 3 (10), e3341, 2008 | 186 | 2008 |
| MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma PM Costa, AL Cardoso, C Custódia, P Cunha, LP de Almeida, ... Journal of Controlled Release 207, 31-39, 2015 | 172 | 2015 |
| Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model JR Guedes, CM Custodia, RJ Silva, LP de Almeida, MC Pedroso de Lima, ... Human molecular genetics 23 (23), 6286-6301, 2014 | 142 | 2014 |
| Calpastatin-mediated inhibition of calpains in the mouse brain prevents mutant ataxin 3 proteolysis, nuclear localization and aggregation, relieving Machado–Joseph disease AT Simoes, N Gonçalves, A Koeppen, N Deglon, S Kügler, CB Duarte, ... Brain 135 (8), 2428-2439, 2012 | 133 | 2012 |
| Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice C Nóbrega, I Nascimento-Ferreira, I Onofre, D Albuquerque, H Hirai, ... PloS one 8 (1), e52396, 2013 | 128 | 2013 |
| Dose-dependent neuroprotective effect of ciliary neurotrophic factor delivered via tetracycline-regulated lentiviral vectors in the quinolinic acid rat model of Huntington's … E Regulier, L Pereira de Almeida, B Sommer, P Aebischer, N Deglon Human gene therapy 13 (16), 1981-1990, 2002 | 127 | 2002 |
| Silencing ataxin-3 mitigates degeneration in a rat model of Machado–Joseph disease: no role for wild-type ataxin-3? S Alves, I Nascimento-Ferreira, N Dufour, R Hassig, G Auregan, ... Human molecular genetics 19 (12), 2380-2394, 2010 | 125 | 2010 |
| siRNA delivery by a transferrin‐associated lipid‐based vector: a non‐viral strategy to mediate gene silencing ALC Cardoso, S Simoes, LP De Almeida, J Pelisek, C Culmsee, ... The Journal of Gene Medicine: A cross‐disciplinary journal for research on …, 2007 | 119 | 2007 |
| Role of hypothalamic neurogenesis in feeding regulation L Sousa-Ferreira, LP de Almeida, C Cavadas Trends in Endocrinology & Metabolism 25 (2), 80-88, 2014 | 116 | 2014 |
| Tumor-targeted chlorotoxin-coupled nanoparticles for nucleic acid delivery to glioblastoma cells: a promising system for glioblastoma treatment PM Costa, AL Cardoso, LS Mendonça, A Serani, C Custódia, ... Molecular Therapy-Nucleic Acids 2, e100, 2013 | 113 | 2013 |
| Striatal and nigral pathology in a lentiviral rat model of Machado-Joseph disease S Alves, E Régulier, I Nascimento-Ferreira, R Hassig, N Dufour, ... Human molecular genetics 17 (14), 2071-2083, 2008 | 103 | 2008 |
| Neuropeptide Y (NPY) as a therapeutic target for neurodegenerative diseases J Duarte-Neves, LP de Almeida, C Cavadas Neurobiology of disease 95, 210-224, 2016 | 102 | 2016 |
Claudia CavadasUniversity of Coimbra, Center for Neurosciences and Cell Biology and Faculty of PharmacyVerified email at uc.pt
