| Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases JR Somoza, RJ Skene, BA Katz, C Mol, JD Ho, AJ Jennings, C Luong, ... Structure 12 (7), 1325-1334, 2004 | 833 | 2004 |
| Clinical targeting of HIV capsid protein with a long-acting small molecule JO Link, MS Rhee, WC Tse, J Zheng, JR Somoza, W Rowe, R Begley, ... Nature 584 (7822), 614-618, 2020 | 245 | 2020 |
| Structural, biochemical, and biophysical characterization of idelalisib binding to phosphoinositide 3-kinase δ JR Somoza, D Koditek, AG Villaseñor, N Novikov, MH Wong, A Liclican, ... Journal of Biological Chemistry 290 (13), 8439-8446, 2015 | 159 | 2015 |
| Structural and kinetic analysis of Escherichia coli GDP-mannose 4, 6 dehydratase provides insights into the enzyme’s catalytic mechanism and regulation by GDP-fucose JR Somoza, S Menon, H Schmidt, D Joseph-McCarthy, A Dessen, ... Structure 8 (2), 123-135, 2000 | 128 | 2000 |
| Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease SX Wang, KC Pandey, JR Somoza, PS Sijwali, T Kortemme, LS Brinen, ... Proceedings of the National Academy of Sciences 103 (31), 11503-11508, 2006 | 122 | 2006 |
| Visualizing ATP-dependent RNA translocation by the NS3 helicase from HCV TC Appleby, R Anderson, O Fedorova, AM Pyle, R Wang, X Liu, ... Journal of molecular biology 405 (5), 1139-1153, 2011 | 119 | 2011 |
| Crystal Structure of the Hypoxanthine−Guanine−Xanthine Phosphoribosyltransferase from the Protozoan Parasite Tritrichomonas foetus, JR Somoza, MS Chin, PJ Focia, CC Wang, RJ Fletterick Biochemistry 35 (22), 7032-7040, 1996 | 119 | 1996 |
| Design and synthesis of tri-ring P3 benzamide-containing aminonitriles as potent, selective, orally effective inhibitors of cathepsin K JT Palmer, C Bryant, DX Wang, DE Davis, EL Setti, RM Rydzewski, ... Journal of medicinal chemistry 48 (24), 7520-7534, 2005 | 112 | 2005 |
| Crystal structure of human cathepsin S ME Mcgrath, JT Palmer, D Brömme, JR Somoza Protein science 7 (6), 1294-1302, 1998 | 112 | 1998 |
| Crystal Structure of Human Cathepsin V, JR Somoza, H Zhan, KK Bowman, L Yu, KD Mortara, JT Palmer, JM Clark, ... Biochemistry 39 (41), 12543-12551, 2000 | 111 | 2000 |
| The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain JR Somoza, JD Ho, C Luong, M Ghate, PA Sprengeler, K Mortara, ... Structure 11 (9), 1123-1131, 2003 | 105 | 2003 |
| Two Crystal Structures of a Potently Sweet Protein: Natural Monellin at 2· 75 Å Resolution and Single-Chain Monellin at 1· 7 Å Resolution JR Somoza, F Jiang, L Tong, CH Kang, JM Cho, SH Kim Journal of molecular biology 234 (2), 390-404, 1993 | 101 | 1993 |
| The crystal structure of human cathepsin F and its implications for the development of novel immunomodulators JR Somoza, JT Palmer, JD Ho Journal of molecular biology 322 (3), 559-568, 2002 | 80 | 2002 |
| Crystal Structure of Tritrichomonas foetus Inosine-5‘-monophosphate Dehydrogenase and the Enzyme−Product Complex FG Whitby, H Luecke, P Kuhn, JR Somoza, JA Huete-Perez, JD Phillips, ... Biochemistry 36 (35), 10666-10674, 1997 | 76 | 1997 |
| Quinolones as HCV NS5B polymerase inhibitors DV Kumar, R Rai, KA Brameld, JR Somoza, R Rajagopalan, JW Janc, ... Bioorganic & medicinal chemistry letters 21 (1), 82-87, 2011 | 59 | 2011 |
| Rational design of novel antimicrobials: blocking purine salvage in a parasitic protozoan JR Somoza, AG Skillman, NR Munagala, CM Oshiro, RMA Knegtel, ... Biochemistry 37 (16), 5344-5348, 1998 | 59 | 1998 |
| Coupling between trans/cis proline isomerization and protein stability in staphylococcal nuclease DM Truckses, KE Prehoda, SC Miller, JL Markley, JR Somoza Protein science 5 (9), 1907-1916, 1996 | 52 | 1996 |
| 2, 4, 6-Triaminopyrimidine as a novel hinge binder in a series of PI3Kδ selective inhibitors L Patel, J Chandrasekhar, J Evarts, AC Haran, C Ip, JA Kaplan, M Kim, ... Journal of Medicinal Chemistry 59 (7), 3532-3548, 2016 | 50 | 2016 |
| The taste-active regions of monellin, a potently sweet protein JR Somoza, JM Cho, SH Kim Chemical senses 20 (1), 61-68, 1995 | 49 | 1995 |
| Atropisomerism by design: discovery of a selective and stable phosphoinositide 3-kinase (PI3K) β inhibitor J Chandrasekhar, R Dick, J Van Veldhuizen, D Koditek, EI Lepist, ... Journal of Medicinal Chemistry 61 (15), 6858-6868, 2018 | 47 | 2018 |
