A stable trimeric influenza hemagglutinin stem as a broadly protective immunogen A Impagliazzo, F Milder, H Kuipers, MV Wagner, X Zhu, RMB Hoffman, ... Science 349 (6254), 1301-1306, 2015 | 563 | 2015 |
Redox-based reagents for chemoselective methionine bioconjugation S Lin, X Yang, S Jia, AM Weeks, M Hornsby, PS Lee, RV Nichiporuk, ... Science 355 (6325), 597-602, 2017 | 424 | 2017 |
Structural delineation of a quaternary, cleavage-dependent epitope at the gp41-gp120 interface on intact HIV-1 Env trimers C Blattner, JH Lee, K Sliepen, R Derking, E Falkowska, AT de la Peña, ... Immunity 40 (5), 669-680, 2014 | 389 | 2014 |
Recombinant HIV envelope trimer selects for quaternary-dependent antibodies targeting the trimer apex D Sok, MJ van Gils, M Pauthner, JP Julien, KL Saye-Francisco, J Hsueh, ... Proceedings of the National Academy of Sciences 111 (49), 17624-17629, 2014 | 368 | 2014 |
Arylfluorosulfates inactivate intracellular lipid binding protein (s) through chemoselective SuFEx reaction with a binding site Tyr residue W Chen, J Dong, L Plate, DE Mortenson, GJ Brighty, S Li, Y Liu, ... Journal of the American Chemical Society 138 (23), 7353-7364, 2016 | 221 | 2016 |
A common solution to group 2 influenza virus neutralization RHE Friesen, PS Lee, EJM Stoop, RMB Hoffman, DC Ekiert, G Bhabha, ... Proceedings of the National Academy of Sciences 111 (1), 450-455, 2013 | 197 | 2013 |
Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity PS Lee, R Yoshida, DC Ekiert, N Sakai, Y Suzuki, A Takada, IA Wilson Proceedings of the National Academy of Sciences 109 (42), 17040-17045, 2012 | 192 | 2012 |
Recent H3N2 viruses have evolved specificity for extended, branched human-type receptors, conferring potential for increased avidity W Peng, RP de Vries, OC Grant, AJ Thompson, R McBride, B Tsogtbaatar, ... Cell host & microbe 21 (1), 23-34, 2017 | 186 | 2017 |
Receptor mimicry by antibody F045–092 facilitates universal binding to the H3 subtype of influenza virus PS Lee, N Ohshima, RL Stanfield, W Yu, Y Iba, Y Okuno, Y Kurosawa, ... Nature communications 5 (1), 3614, 2014 | 184 | 2014 |
Antibody Recognition of the Pandemic H1N1 Influenza Virus Hemagglutinin Receptor Binding Site M Hong, PS Lee, RMB Hoffman, X Zhu, JC Krause, NS Laursen, S Yoon, ... Journal of Virology 87 (22), 12471-12480, 2013 | 148 | 2013 |
Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site EM Strauch, SM Bernard, D La, AJ Bohn, PS Lee, CE Anderson, ... Nature biotechnology 35 (7), 667-671, 2017 | 127 | 2017 |
Characterization of a broadly neutralizing monoclonal antibody that targets the fusion domain of group 2 influenza A virus hemagglutinin GS Tan, PS Lee, RMB Hoffman, B Mazel-Sanchez, F Krammer, PE Leon, ... Journal of virology 88 (23), 13580-13592, 2014 | 126 | 2014 |
Structural insights into key sites of vulnerability on HIV‐1 Env and influenza HA JP Julien, PS Lee, IA Wilson Immunological Reviews 250 (1), 180-198, 2012 | 110 | 2012 |
Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies PS Lee, IA Wilson Influenza Pathogenesis and Control-Volume II, 323-341, 2014 | 97 | 2014 |
Cacidases: caspases can cleave after aspartate, glutamate and phosphoserine residues JE Seaman, O Julien, PS Lee, TJ Rettenmaier, ND Thomsen, JA Wells Cell Death & Differentiation 23 (10), 1717-1726, 2016 | 82 | 2016 |
A computationally designed hemagglutinin stem-binding protein provides in vivo protection from influenza independent of a host immune response MT Koday, J Nelson, A Chevalier, M Koday, H Kalinoski, L Stewart, ... PLoS pathogens 12 (2), e1005409, 2016 | 59 | 2016 |
Structural Basis of DNA Recognition by the Alternative Sigma-factor, σ54 M Doucleff, JG Pelton, PS Lee, BT Nixon, DE Wemmer Journal of Molecular Biology 369 (4), 1070-1078, 2007 | 56 | 2007 |
Design and structure of an engineered disulfide-stabilized influenza virus hemagglutinin trimer PS Lee, X Zhu, W Yu, IA Wilson Journal of virology 89 (14), 7417-7420, 2015 | 42 | 2015 |
Structural mechanism of GAF-regulated σ54 activators from Aquifex aeolicus JD Batchelor, PS Lee, AC Wang, M Doucleff, DE Wemmer Journal of molecular biology 425 (1), 156-170, 2013 | 20 | 2013 |
Cancer immunotherapy and the nectin family RJ Johnston, PS Lee, P Strop, MJ Smyth Annual Review of Cancer Biology 5, 203-219, 2021 | 18 | 2021 |