Matthew D. Lloyd
Matthew D. Lloyd
Senior Lecturer (Associate Professor) of Pharmacy & Pharmacology, University of Bath, United Kingdom
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Structure of a cephalosporin synthase
K Valegård, ACT Van Scheltinga, MD Lloyd, T Hara, S Ramaswamy, ...
Nature 394 (6695), 805-809, 1998
The iron (II) and 2-oxoacid-dependent dioxygenases and their role in metabolism
AG Prescott, MD Lloyd
Natural product reports 17 (4), 367-383, 2000
Refsum's disease: a peroxisomal disorder affecting phytanic acid α‐oxidation
AS Wierzbicki, MD Lloyd, CJ Schofield, MD Feher, FB Gibberd
Journal of neurochemistry 80 (5), 727-735, 2002
The advantages and limitations of protein crystal structures
KR Acharya, MD Lloyd
Trends in pharmacological sciences 26 (1), 10-14, 2005
Pentalenene synthase. Purification, molecular cloning, sequencing, and high-level expression in Escherichia coli of a terpenoid cyclase from Streptomyces UC5319
DE Cane, JK Sohng, CR Lamberson, SM Rudnicki, Z Wu, MD Lloyd, ...
Biochemistry 33 (19), 5846-5857, 1994
α‐Methylacyl‐CoA racemase–an ‘obscure’metabolic enzyme takes centre stage
MD Lloyd, DJ Darley, AS Wierzbicki, MD Threadgill
The FEBS journal 275 (6), 1089-1102, 2008
Studies on the active site of deacetoxycephalosporin C synthase
MD Lloyd, HJ Lee, K Harlos, ZH Zhang, JE Baldwin, CJ Schofield, ...
Journal of molecular biology 287 (5), 943-960, 1999
Kinetic and crystallographic studies on deacetoxycephalosporin C synthase (DAOCS)
HJ Lee, MD Lloyd, K Harlos, IJ Clifton, JE Baldwin, CJ Schofield
Journal of molecular biology 308 (5), 937-948, 2001
α-Methylacyl-CoA racemase (AMACR): metabolic enzyme, drug metabolizer and cancer marker P504S
MD Lloyd, M Yevglevskis, GL Lee, PJ Wood, MD Threadgill, TJ Woodman
Progress in lipid research 52 (2), 220-230, 2013
The chemical biology of branched-chain lipid metabolism
M Mukherji, CJ Schofield, AS Wierzbicki, GA Jansen, RJA Wanders, ...
Progress in lipid research 42 (5), 359-376, 2003
Phytanic acid alpha-oxidation, new insights into an old problem: a review
RJA Wanders, GA Jansen, MD Lloyd
Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids …, 2003
Design, synthesis, and evaluation in vitro of quinoline-8-carboxamides, a new class of poly (adenosine-diphosphate-ribose) polymerase-1 (PARP-1) inhibitor
AM Lord, MF Mahon, MD Lloyd, MD Threadgill
Journal of medicinal chemistry 52 (3), 868-877, 2009
Structure–function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum’s disease
M Mukherji, W Chien, NJ Kershaw, IJ Clifton, CJ Schofield, AS Wierzbicki, ...
Human molecular genetics 10 (18), 1971-1982, 2001
Utilization of sterol carrier protein-2 by phytanoyl-CoA 2-hydroxylase in the peroxisomal α oxidation of phytanic acid
M Mukherji, NJ Kershaw, CJ Schofield, AS Wierzbicki, MD Lloyd
Chemistry & biology 9 (5), 597-605, 2002
Long-wavelength TCF-based fluorescence probes for the detection and intracellular imaging of biological thiols
AC Sedgwick, JE Gardiner, G Kim, M Yevglevskis, MD Lloyd, ATA Jenkins, ...
Chemical communications 54 (38), 4786-4789, 2018
Product-substrate engineering by bacteria: studies on clavaminate synthase, a trifunctional dioxygenase
MD Lloyd, KD Merritt, V Lee, TJ Sewell, B Wha-Son, JE Baldwin, ...
Tetrahedron 55 (33), 10201-10220, 1999
High-throughput screening for the discovery of enzyme inhibitors
MD Lloyd
Journal of Medicinal Chemistry 63 (19), 10742-10772, 2020
Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S)—A potential mechanism for the anti-cancer effects of ibuprofen
TJ Woodman, PJ Wood, AS Thompson, TJ Hutchings, GR Steel, P Jiao, ...
Chemical communications 47 (26), 7332-7334, 2011
5-Benzamidoisoquinolin-1-ones and 5-(ω-carboxyalkyl) isoquinolin-1-ones as isoform-selective inhibitors of poly (ADP-ribose) polymerase 2 (PARP-2)
PT Sunderland, ECY Woon, A Dhami, AB Bergin, MF Mahon, PJ Wood, ...
Journal of medicinal chemistry 54 (7), 2049-2059, 2011
Crystal structure of human carbonic anhydrase II at 1.95 Å resolution in complex with 667-coumate, a novel anti-cancer agent
MD Lloyd, RL Pederick, R Natesh, LWL Woo, A Purohit, MJ Reed, ...
Biochemical Journal 385 (3), 715-720, 2005
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