| pH-degradable imidazoquinoline-ligated nanogels for lymph node-focused immune activation L Nuhn, N Vanparijs, A De Beuckelaer, L Lybaert, G Verstraete, ... Proceedings of the National Academy of Sciences 113 (29), 8098-8103, 2016 | 191 | 2016 |
| Structure− activity relationships in human Toll-like receptor 7-active imidazoquinoline analogues NM Shukla, SS Malladi, CA Mutz, R Balakrishna, SA David Journal of medicinal chemistry 53 (11), 4450-4465, 2010 | 183 | 2010 |
| Antibacterial activities of Groebke–Blackburn–Bienaymé-derived imidazo [1, 2-a] pyridin-3-amines NM Shukla, DB Salunke, E Yoo, CA Mutz, R Balakrishna, SA David Bioorganic & medicinal chemistry 20 (19), 5850-5863, 2012 | 131 | 2012 |
| Structural analyses of toll-like receptor 7 reveal detailed RNA sequence specificity and recognition mechanism of agonistic ligands Z Zhang, U Ohto, T Shibata, M Taoka, Y Yamauchi, R Sato, NM Shukla, ... Cell reports 25 (12), 3371-3381. e5, 2018 | 114 | 2018 |
| Potential adjuvantic properties of innate immune stimuli HJ Warshakoon, JD Hood, MR Kimbrell, S Malladi, WY Wu, N Shukla, ... Human vaccines 5 (6), 381-394, 2009 | 113 | 2009 |
| Structure–Activity Relationships in Human Toll-like Receptor 8-Active 2,3-Diamino-furo[2,3-c]pyridines DB Salunke, E Yoo, NM Shukla, R Balakrishna, SS Malladi, KJ Serafin, ... Journal of medicinal chemistry 55 (18), 8137-8151, 2012 | 91 | 2012 |
| Potent adjuvanticity of a pure TLR7-agonistic imidazoquinoline dendrimer NM Shukla, DB Salunke, R Balakrishna, CA Mutz, SS Malladi, SA David Public Library of Science 7 (8), e43612, 2012 | 84 | 2012 |
| Toll-like receptor (TLR)-7 and-8 modulatory activities of dimeric imidazoquinolines NM Shukla, CA Mutz, SS Malladi, HJ Warshakoon, R Balakrishna, ... Journal of medicinal chemistry 55 (3), 1106-1116, 2012 | 82 | 2012 |
| Toward self-adjuvanting subunit vaccines: model peptide and protein antigens incorporating covalently bound toll-like receptor-7 agonistic imidazoquinolines NM Shukla, TC Lewis, TP Day, CA Mutz, R Ukani, CD Hamilton, ... Bioorganic & medicinal chemistry letters 21 (11), 3232-3236, 2011 | 76 | 2011 |
| Syntheses of fluorescent imidazoquinoline conjugates as probes of Toll-like receptor 7 NM Shukla, CA Mutz, R Ukani, HJ Warshakoon, DS Moore, SA David Bioorganic & medicinal chemistry letters 20 (22), 6384-6386, 2010 | 66 | 2010 |
| Immunoprofiling toll-like receptor ligands: Comparison of immunostimulatory and proinflammatory profiles in ex vivo human blood models JD Hood, HJ Warshakoon, MR Kimbrell, NM Shukla, SS Malladi, X Wang, ... Human vaccines 6 (4), 322-335, 2010 | 64 | 2010 |
| Regioisomerism-dependent TLR7 agonism and antagonism in an imidazoquinoline NM Shukla, MR Kimbrell, SS Malladi, SA David Bioorganic & medicinal chemistry letters 19 (8), 2211-2214, 2009 | 61 | 2009 |
| Structure–activity relationships in human Toll-like receptor 2-specific monoacyl lipopeptides DB Salunke, NM Shukla, E Yoo, BM Crall, R Balakrishna, SS Malladi, ... Journal of medicinal chemistry 55 (7), 3353-3363, 2012 | 60 | 2012 |
| The imidazoquinoline toll-like receptor-7/8 agonist hybrid-2 potently induces cytokine production by human newborn and adult leukocytes L Ganapathi, S Van Haren, DJ Dowling, I Bergelson, NM Shukla, ... PLoS One 10 (8), e0134640, 2015 | 56 | 2015 |
| Preliminary evaluation of a 3H imidazoquinoline library as dual TLR7/TLR8 antagonists NM Shukla, SS Malladi, V Day, SA David Bioorganic & medicinal chemistry 19 (12), 3801-3811, 2011 | 52 | 2011 |
| Design and development of stable, water-soluble, human Toll-like receptor 2 specific monoacyl lipopeptides as candidate vaccine adjuvants DB Salunke, SW Connelly, NM Shukla, AR Hermanson, LM Fox, ... Journal of medicinal chemistry 56 (14), 5885-5900, 2013 | 50 | 2013 |
| Toll-like receptor-7 and-8 modulatory 1H imidazoquinoline derived compounds SA David, NM Shukla US Patent 8,728,486, 2014 | 42 | 2014 |
| Identification of a Human Toll-like Receptor (TLR) 8-specific Agonist and a Functional Pan-TLR Inhibitor in 2-Aminoimidazoles M Beesu, G Caruso, ACD Salyer, NM Shukla, KK Khetani, LJ Smith, ... Journal of medicinal chemistry 59 (7), 3311-3330, 2016 | 39 | 2016 |
| Hyaluronic acid conjugates of TLR7/8 agonists for targeted delivery to secondary lymphoid tissue E Yoo, ACD Salyer, MJH Brush, Y Li, KL Trautman, NM Shukla, ... Bioconjugate chemistry 29 (8), 2741-2754, 2018 | 27 | 2018 |
| Structure–Activity Relationship Studies of Pyrimido[5,4-b]indoles as Selective Toll-Like Receptor 4 Ligands M Chan, Y Kakitsubata, T Hayashi, A Ahmadi, S Yao, NM Shukla, ... Journal of medicinal chemistry 60 (22), 9142-9161, 2017 | 24 | 2017 |
