| Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation T Afroz, EM Hock, P Ernst, C Foglieni, M Jambeau, LAB Gilhespy, ... Nature communications 8 (1), 45, 2017 | 270 | 2017 |
| TDP-43 extracted from frontotemporal lobar degeneration subject brains displays distinct aggregate assemblies and neurotoxic effects reflecting disease progression rates F Laferrière, Z Maniecka, M Pérez-Berlanga, M Hruska-Plochan, ... Nature neuroscience 22 (1), 65-77, 2019 | 149 | 2019 |
| One, two, three, four! How multiple RRMs read the genome sequence T Afroz, Z Cienikova, A Cléry, FHT Allain Methods in enzymology 558, 235-278, 2015 | 102 | 2015 |
| A fly trap mechanism provides sequence-specific RNA recognition by CPEB proteins T Afroz, L Skrisovska, E Belloc, J Guillén-Boixet, R Méndez, FHT Allain Genes & development 28 (13), 1498-1514, 2014 | 90 | 2014 |
| Gilhespy LAB, Laferriere F, Maniecka Z, Plückthun A, Mittl P et al (2017) Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic … T Afroz, EM Hock, P Ernst, C Foglieni, M Jambeau Nat Commun 8 (45), 536-543, 2017 | 56 | 2017 |
| Split GFP technologies to structurally characterize and quantify functional biomolecular interactions of FTD-related proteins C Foglieni, S Papin, A Salvadè, T Afroz, S Pinton, G Pedrioli, G Ulrich, ... Scientific reports 7 (1), 14013, 2017 | 41 | 2017 |
| Memory decline and its reversal in aging and neurodegeneration involve miR-183/96/182 biogenesis A Jawaid, BT Woldemichael, EA Kremer, F Laferriere, N Gaur, T Afroz, ... Molecular neurobiology 56, 3451-3462, 2019 | 35 | 2019 |
| Structural transition, function and dysfunction of TDP-43 in neurodegenerative diseases T Afroz, M Pérez-Berlanga, M Polymenidou Chimia 73 (5), 380-380, 2019 | 21 | 2019 |
| Gilhespy LAB, Laferriere F, Maniecka Z, Pluckthun A, Mittl P, Paganetti P, Allain FHT, Polymenidou M (2017) Functional and dynamic polymerization of the ALS-linked protein TDP … T Afroz, EM Hock, P Ernst, C Foglieni, M Jambeau Nat Commun 8 (1), 45, 0 | 19 | |
| Functional and dynamic polymerization of the ALS-linked protein TDP-43 antagonizes its pathologic aggregation. Nat Commun 8: 45 T Afroz, EM Hock, P Ernst, C Foglieni, M Jambeau, L Gilhespy, ... | 10 | 2017 |
| Immunotherapy targeting the C-terminal domain of TDP-43 decreases neuropathology and confers neuroprotection in mouse models of ALS/FTD T Afroz, E Chevalier, M Audrain, C Dumayne, T Ziehm, R Moser, ... Neurobiology of Disease 179, 106050, 2023 | 8 | 2023 |
| Insight into the role of histidine in RNR motif of protein component of RNase P of M. tuberculosis in catalysis A Singh, AK Ramteke, T Afroz, JK Batra IUBMB life 68 (3), 178-189, 2016 | 4 | 2016 |
| Improved antibody pharmacokinetics by disruption of contiguous positive surface potential and charge reduction using alternate human framework R Ollier, A Fuchs, F Gauye, K Piorkowska, S Menant, M Ratnam, ... MAbs 15 (1), 2232087, 2023 | 3 | 2023 |
| Distinct TDP-43 aggregate features and toxicity stratify FTD patients F Laferriere, Z Maniecja, M Perez-Berlanga, M Hruska-Plochan, G Larissa, ... Nature Neuroscience, 2019 | 1 | 2019 |
| Discovery and optimization of the first‐in‐class TDP‐43 PET tracer T Seredenina, E Vokali, N Dreyfus, E Chevallier, T Afroz, T Jaquier, ... Alzheimer's & Dementia 19, e075525, 2023 | | 2023 |
| Development of TDP‐43 immunotherapy blocking transmission of seeding‐competent species from ALS/FTD T Afroz Alzheimer's & Dementia 19, e075520, 2023 | | 2023 |
| Humanized Anti-TDP-43 Binding Molecules and Uses Thereof T Seredenina, TM Ziehm, T Afroz, RC Ollier US Patent App. 18/020,593, 2023 | | 2023 |
| TDP-43 proteinopathy in neurodegenerative diseases: current understanding of pathobiology and development of therapeutics and diagnostics VMMY Lee, T Afroz Alzheimer's Association International Conference, 2023 | | 2023 |
| Targeting amyotrophic lateral sclerosis by neutralizing seeding-competent TDP-43 in CSF M Audrain, AL Egesipe, N Tentillier, L Font, M Ratnam, L Mottier, M Clavel, ... Brain Communications 5 (6), fcad306, 2023 | | 2023 |
| Anti-TDP-43 Binding Molecules and Uses Thereof T Seredenina, TM Ziehm, T Afroz US Patent App. 17/613,444, 2022 | | 2022 |
Magdalini PolymenidouAssociate Professor for Biomedicine, Department of Quantitative Biomedicine, University of ZurichVerified email at imls.uzh.ch
