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John O. Miners
John O. Miners
Matthew Flinders Distinguished Professor
Verificeret mail på flinders.edu.au
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Cytochrome P4502C9: an enzyme of major importance in human drug metabolism
JO Miners, DJ Birkett
British journal of clinical pharmacology 45 (6), 525-538, 1998
11201998
Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily
PI Mackenzie, KW Bock, B Burchell, C Guillemette, S Ikushiro, T Iyanagi, ...
Pharmacogenetics and genomics 15 (10), 677-685, 2005
9712005
The role of the CFP2C9-Leu 359 allelic variant in the tolbutamide polymorphism
TH Sullivan-Klose, BI Ghanayem, DA Bell, ZY Zhang, LS Kaminsky, ...
Pharmacogenetics and Genomics 6 (4), 341-349, 1996
8201996
The UDP-glucuronosyltransferases: their role in drug metabolism and detoxification
A Rowland, JO Miners, PI Mackenzie
The international journal of biochemistry & cell biology 45 (6), 1121-1132, 2013
6902013
Drug glucuronidation in humans
JO Miners, PI Mackenzie
Pharmacology & therapeutics 51 (3), 347-369, 1991
4621991
Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.
W Tassaneeyakul, DJ Birkett, ME Veronese, ME McManus, RH Tukey, ...
Journal of Pharmacology and Experimental Therapeutics 265 (1), 401-407, 1993
4131993
Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by …
V Uchaipichat, PI Mackenzie, XH Guo, D Gardner-Stephen, A Galetin, ...
Drug Metabolism and Disposition 32 (4), 413-423, 2004
3792004
The effects of buthionine sulphoximine (BSO) on glutathione depletion and xenobiotic biotransformation
R Drew, JO Miners
Biochemical pharmacology 33 (19), 2989-2994, 1984
3001984
Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance
CR Bhasker, W McKinnon, A Stone, ACT Lo, T Kubota, T Ishizaki, ...
Pharmacogenetics and Genomics 10 (8), 679-685, 2000
2962000
Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance
JO Miners, RA McKinnon, PI Mackenzie
Toxicology 181, 453-456, 2002
2762002
Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.
C Jin, JO Miners, KJ Lillywhite, PI Mackenzie
Journal of Pharmacology and Experimental Therapeutics 264 (1), 475-479, 1993
2741993
Identification of human liver cytochrome P450 isoforms mediating omeprazole metabolism
T ANDERSSON, JO MINERS, ME VERONESE, W Tassaneeyakul, ...
British journal of clinical pharmacology 36 (6), 521-530, 1993
2731993
Diazepam metabolism by human liver microsomes is mediated by both S‐mephenytoin hydroxylase and CYP3A isoforms.
T Andersson, JO Miners, ME Veronese, DJ Birkett
British journal of clinical pharmacology 38 (2), 131-137, 1994
2701994
Tolbutamide and phenytoin hydroxylations by cDNA-expressed human liver cytochrome P4502C9
ME Veronese, PI Mackenzie, CJ Doecke, ME McManus, JO Miners, ...
Biochemical and biophysical research communications 175 (3), 1112-1118, 1991
2701991
In vitro–in vivo correlation for drugs and other compounds eliminated by glucuronidation in humans: pitfalls and promises
JO Miners, KM Knights, JB Houston, PI Mackenzie
Biochemical pharmacology 71 (11), 1531-1539, 2006
2622006
Selectivity of substrate (trifluoperazine) and inhibitor (amitriptyline, androsterone, canrenoic acid, hecogenin, phenylbutazone, quinidine, quinine, and sulfinpyrazone)“probes …
V Uchaipichat, PI Mackenzie, DJ Elliot, JO Miners
Drug metabolism and disposition 34 (3), 449-456, 2006
2562006
In vitro characterization of lamotrigine N2-glucuronidation and the lamotrigine-valproic acid interaction
A Rowland, DJ Elliot, JA Williams, PI Mackenzie, RG Dickinson, ...
Drug Metabolism and Disposition 34 (6), 1055-1062, 2006
2552006
The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro …
JO Miners, PI Mackenzie, KM Knights
Drug metabolism reviews 42 (1), 196-208, 2010
2502010
Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches
JO Miners, PA Smith, MJ Sorich, RA McKinnon, PI Mackenzie
Annu. Rev. Pharmacol. Toxicol. 44, 1-25, 2004
2502004
Isoform selectivity and kinetics of morphine 3-and 6-glucuronidation by human UDP-glucuronosyltransferases: evidence for atypical glucuronidation kinetics by UGT2B7
AN Stone, PI Mackenzie, A Galetin, JB Houston, JO Miners
Drug Metabolism and Disposition 31 (9), 1086-1089, 2003
2442003
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