| Two tarantula peptides inhibit activation of multiple sodium channels RE Middleton, VA Warren, RL Kraus, JC Hwang, CJ Liu, G Dai, ... Biochemistry 41 (50), 14734-14747, 2002 | 282 | 2002 |
| Drug-resistant Drosophila indicate glutamate-gated chloride channels are targets for the antiparasitics nodulisporic acid and ivermectin NS Kane, B Hirschberg, S Qian, D Hunt, B Thomas, R Brochu, ... Proceedings of the National Academy of Sciences 97 (25), 13949-13954, 2000 | 239 | 2000 |
| Sodium channel blockade may contribute to the analgesic efficacy of antidepressants IE Dick, RM Brochu, Y Purohit, GJ Kaczorowski, WJ Martin, BT Priest The Journal of Pain 8 (4), 315-324, 2007 | 209 | 2007 |
| Functional assay of voltage-gated sodium channels using membrane potential-sensitive dyes JP Felix, BS Williams, BT Priest, RM Brochu, IE Dick, VA Warren, L Yan, ... Assay and drug development technologies 2 (3), 260-268, 2004 | 100 | 2004 |
| Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator MHM Smith, VA Warren, BS Thomas, RM Brochu, EA Ertel, S Rohrer, ... Biochemistry 39 (18), 5543-5554, 2000 | 89 | 2000 |
| Characterization of a new class of potent inhibitors of the voltage-gated sodium channel Nav1. 7 BS Williams, JP Felix, BT Priest, RM Brochu, K Dai, SB Hoyt, C London, ... Biochemistry 46 (50), 14693-14703, 2007 | 74 | 2007 |
| Block of peripheral nerve sodium channels selectively inhibits features of neuropathic pain in rats RM Brochu, IE Dick, JW Tarpley, E McGowan, D Gunner, J Herrington, ... Molecular pharmacology 69 (3), 823-832, 2006 | 63 | 2006 |
| Stichodactyla helianthus peptide, a pharmacological tool for studying Kv3. 2 channels L Yan, J Herrington, E Goldberg, PM Dulski, RM Bugianesi, RS Slaughter, ... Molecular pharmacology 67 (5), 1513-1521, 2005 | 59 | 2005 |
| Potassium channel blockade: A mechanism for suppressing ventricular fibrillation. MB Bacaner, JR Clay, A Shrier, RM Brochu Proceedings of the National Academy of Sciences 83 (7), 2223-2227, 1986 | 59 | 1986 |
| Discovery of selective small molecule ROMK inhibitors as potential new mechanism diuretics H Tang, SP Walsh, Y Yan, RK de Jesus, A Shahripour, N Teumelsan, ... ACS Medicinal Chemistry Letters 3 (5), 367-372, 2012 | 47 | 2012 |
| WIN 17317-3, a new high-affinity probe for voltage-gated sodium channels SG Wanner, H Glossmann, HG Knaus, R Baker, W Parsons, ... Biochemistry 38 (34), 11137-11146, 1999 | 46 | 1999 |
| A high-capacity membrane potential FRET-based assay for NaV1. 8 channels CJ Liu, BT Priest, RM Bugianesi, PM Dulski, JP Felix, IE Dick, RM Brochu, ... Assay and drug development technologies 4 (1), 37-48, 2006 | 45 | 2006 |
| Biophysical and pharmacological properties of the voltage‐gated potassium current of human pancreatic β‐cells J Herrington, M Sanchez, D Wunderler, L Yan, RM Bugianesi, IE Dick, ... The Journal of Physiology 567 (1), 159-175, 2005 | 43 | 2005 |
| A disubstituted succinamide is a potent sodium channel blocker with efficacy in a rat pain model BT Priest, ML Garcia, RE Middleton, RM Brochu, S Clark, G Dai, IE Dick, ... Biochemistry 43 (30), 9866-9876, 2004 | 36 | 2004 |
| Pharmacologic inhibition of the renal outer medullary potassium channel causes diuresis and natriuresis in the absence of kaliuresis ML Garcia, BT Priest, M Alonso-Galicia, X Zhou, JP Felix, RM Brochu, ... Journal of Pharmacology and Experimental Therapeutics 348 (1), 153-164, 2014 | 35 | 2014 |
| Pacemaker current in single cells and in aggregates of cells dissociated from the embryonic chick heart. RM Brochu, JR Clay, A Shrier The Journal of Physiology 454 (1), 503-515, 1992 | 33 | 1992 |
| Discovery of MK-7145, an oral small molecule ROMK inhibitor for the treatment of hypertension and heart failure H Tang, Y Zhu, N Teumelsan, SP Walsh, A Shahripour, BT Priest, ... ACS Medicinal Chemistry Letters 7 (7), 697-701, 2016 | 29 | 2016 |
| Discovery of a novel sub-class of ROMK channel inhibitors typified by 5-(2-(4-(2-(4-(1H-Tetrazol-1-yl) phenyl) acetyl) piperazin-1-yl) ethyl) isobenzofuran-1 (3H)-one H Tang, RK de Jesus, SP Walsh, Y Zhu, Y Yan, BT Priest, AM Swensen, ... Bioorganic & medicinal chemistry letters 23 (21), 5829-5832, 2013 | 28 | 2013 |
| Phase resetting of embryonic chick atrial heart cell aggregates. Experiment and theory JR Clay, RM Brochu, A Shrier Biophysical journal 58 (3), 609-621, 1990 | 28 | 1990 |
| Discovery of a novel class of biphenyl pyrazole sodium channel blockers for treatment of neuropathic pain S Tyagarajan, PK Chakravarty, B Zhou, B Taylor, R Eid, MH Fisher, ... Bioorganic & medicinal chemistry letters 20 (24), 7479-7482, 2010 | 27 | 2010 |
