Follow
Anant Akash Agrawal
Anant Akash Agrawal
Remix Therapeutics
Verified email at remixtx.com
Title
Cited by
Cited by
Year
H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
M Seiler, A Yoshimi, R Darman, B Chan, G Keaney, M Thomas, ...
Nature medicine 24 (4), 497-504, 2018
4592018
Cancer-associated SF3B1 hotspot mutations induce cryptic 3′ splice site selection through use of a different branch point
RB Darman, M Seiler, AA Agrawal, KH Lim, S Peng, D Aird, SL Bailey, ...
Cell reports 13 (5), 1033-1045, 2015
4442015
Somatic mutational landscape of splicing factor genes and their functional consequences across 33 cancer types
M Seiler, S Peng, AA Agrawal, J Palacino, T Teng, P Zhu, PG Smith, ...
Cell reports 23 (1), 282-296. e4, 2018
3812018
Structural basis of splicing modulation by antitumor macrolide compounds
C Cretu, AA Agrawal, A Cook, CL Will, P Fekkes, PG Smith, R Lührmann, ...
Molecular cell 70 (2), 265-273. e8, 2018
1492018
Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts
A Mupo, M Seiler, V Sathiaseelan, A Pance, Y Yang, AA Agrawal, F Iorio, ...
Leukemia 31 (3), 720-727, 2017
1372017
The cryo-EM structure of the SF3b spliceosome complex bound to a splicing modulator reveals a pre-mRNA substrate competitive mechanism of action
LI Finci, X Zhang, X Huang, Q Zhou, J Tsai, T Teng, A Agrawal, B Chan, ...
Genes & development 32 (3-4), 309-320, 2018
1092018
Porous nanocrystalline silicon membranes as highly permeable and molecularly thin substrates for cell culture
AA Agrawal, BJ Nehilla, KV Reisig, TR Gaborski, DZ Fang, CC Striemer, ...
Biomaterials 31 (20), 5408-5417, 2010
1042010
Targeting splicing abnormalities in cancer
AA Agrawal, L Yu, PG Smith, S Buonamici
Current opinion in genetics & development 48, 67-74, 2018
732018
An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal
AA Agrawal, E Salsi, R Chatrikhi, S Henderson, JL Jenkins, MR Green, ...
Nature communications 7 (1), 10950, 2016
682016
U2AF65 adapts to diverse pre-mRNA splice sites through conformational selection of specific and promiscuous RNA recognition motifs
JL Jenkins, AA Agrawal, A Gupta, MR Green, CL Kielkopf
Nucleic acids research 41 (6), 3859-3873, 2013
502013
Structural basis of intron selection by U2 snRNP in the presence of covalent inhibitors
C Cretu, P Gee, X Liu, A Agrawal, TV Nguyen, AK Ghosh, A Cook, ...
Nature Communications 12 (1), 4491, 2021
292021
Cancer-associated mutations mapped on high-resolution structures of the U2AF2 RNA recognition motifs
E Glasser, AA Agrawal, JL Jenkins, CL Kielkopf
Biochemistry 56 (36), 4757-4761, 2017
262017
Small molecule inhibition of CPS1 activity through an allosteric pocket
S Yao, TV Nguyen, A Rolfe, AA Agrawal, J Ke, S Peng, F Colombo, S Yu, ...
Cell Chemical Biology 27 (3), 259-268. e5, 2020
212020
Structure-guided U2AF65 variant improves recognition and splicing of a defective pre-mRNA
AA Agrawal, KJ McLaughlin, JL Jenkins, CL Kielkopf
Proceedings of the National Academy of Sciences 111 (49), 17420-17425, 2014
162014
Reprogramming RNA processing: an emerging therapeutic landscape
CR Neil, MW Seiler, DJ Reynolds, JJ Smith, FH Vaillancourt, PG Smith, ...
Trends in Pharmacological Sciences 43 (5), 437-454, 2022
152022
Novel SF3B1 in-frame deletions result in aberrant RNA splicing in CLL patients
AA Agrawal, M Seiler, LT Brinton, R Mantel, R Lapalombella, JA Woyach, ...
Blood Advances 1 (15), 995-1000, 2017
152017
Oligonucleotides useful for modulation of splicing
JJ Smith, D Brown, MW Seiler, P Smith, AA Agrawal
US Patent App. 18/033,748, 2024
2024
2-(indazol-5-yl)-6-(piperidin-4-yl)-1, 7-naphthyridine derivatives and related compounds as modulators for splicing nucleic acids and for the tre
D Reynolds, MW Seiler, AA Agrawal, F Vaillancourt, P Smith, S Vyskocil, ...
US Patent App. 18/014,059, 2024
2024
Heterocyclic amides and their use for modulating splicing
D Reynolds, MW Seiler, AA Agrawal, F Vaillancourt, P Smith
US Patent App. 17/802,719, 2023
2023
Pyridazine derivatives for modulating nucleic acid splicing
D Reynolds, MW Seiler, AA Agrawal, F Vaillancourt, P Smith, AT Hopper
US Patent App. 17/802,747, 2023
2023
The system can't perform the operation now. Try again later.
Articles 1–20