Taosheng Chen
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Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor γ (PPARγ) agonists: PPARγ co-association with transcription factor NFAT
XY Yang, LH Wang, T Chen, DR Hodge, JH Resau, L DaSilva, WL Farrar
Journal of biological chemistry 275 (7), 4541-4544, 2000
Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells
T Chen, LH Wang, WL Farrar
Cancer research 60 (8), 2132-2135, 2000
Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis
DA Rodriguez, R Weinlich, S Brown, C Guy, P Fitzgerald, CP Dillon, ...
Cell Death & Differentiation 23 (1), 76-88, 2016
Role of CAR and PXR in xenobiotic sensing and metabolism
YM Wang, SS Ong, SC Chai, T Chen
Expert opinion on drug metabolism & toxicology 8 (7), 803-817, 2012
A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells: cross-talk between cyclic AMP and protein kinase C pathways
Z Gao, T Chen, MJ Weber, J Linden
Journal of Biological Chemistry 274 (9), 5972-5980, 1999
BOK is a non-canonical BCL-2 family effector of apoptosis regulated by ER-associated degradation
F Llambi, YM Wang, B Victor, M Yang, DM Schneider, S Gingras, ...
Cell 165 (2), 421-433, 2016
Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions
M Sinz, S Kim, Z Zhu, T Chen, M Anthony, K Dickinson, AD Rodrigues
Current drug metabolism 7 (4), 375-388, 2006
Efficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia
ML Churchman, J Low, C Qu, EM Paietta, LH Kasper, Y Chang, ...
Cancer cell 28 (3), 343-356, 2015
Nuclear receptor drug discovery
T Chen
Current opinion in chemical biology 12 (4), 418-426, 2008
Elevation of cyclic adenosine 3′, 5′-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells
T Chen, RW Cho, PJS Stork, MJ Weber
Cancer Research 59 (1), 213-218, 1999
Targeting xenobiotic receptors PXR and CAR in human diseases
M Banerjee, D Robbins, T Chen
Drug discovery today 20 (5), 618-628, 2015
Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL
KG Roberts, YL Yang, D Payne-Turner, W Lin, JK Files, K Dickerson, Z Gu, ...
Blood advances 1 (20), 1657-1671, 2017
A phosphotyrosine switch regulates organic cation transporters
JA Sprowl, SS Ong, AA Gibson, S Hu, G Du, W Lin, L Li, S Bharill, ...
Nature communications 7 (1), 10880, 2016
PXR: more than just a master xenobiotic receptor
PO Oladimeji, T Chen
Molecular pharmacology 93 (2), 119-127, 2018
Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells
W Lin, J Wu, H Dong, D Bouck, FY Zeng, T Chen
Journal of Biological Chemistry 283 (45), 30650-30657, 2008
Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor γ activated by macrophage-derived 12/15…
XY Yang, LH Wang, K Mihalic, W Xiao, T Chen, P Li, LM Wahl, WL Farrar
Journal of Biological Chemistry 277 (6), 3973-3978, 2002
Overcoming drug resistance by regulating nuclear receptors
T Chen
Advanced drug delivery reviews 62 (13), 1257-1264, 2010
Flavonoids activate pregnane receptor-mediated CYP3A4 gene expression by inhibiting cyclin-dependent kinases in HepG2 liver carcinoma cells
H Dong, W Lin, J Wu, T Chen
BMC biochemistry 11, 1-9, 2010
Small-molecule modulators of PXR and CAR
SC Chai, MT Cherian, YM Wang, T Chen
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1859 (9…, 2016
Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions
N Pabla, AA Gibson, M Buege, SS Ong, L Li, S Hu, G Du, JA Sprowl, ...
Proceedings of the National Academy of Sciences 112 (16), 5231-5236, 2015
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