| Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor γ (PPARγ) agonists: PPARγ co-association with transcription factor NFAT XY Yang, LH Wang, T Chen, DR Hodge, JH Resau, L DaSilva, WL Farrar Journal of biological chemistry 275 (7), 4541-4544, 2000 | 520 | 2000 |
| Interleukin 6 activates androgen receptor-mediated gene expression through a signal transducer and activator of transcription 3-dependent pathway in LNCaP prostate cancer cells T Chen, LH Wang, WL Farrar Cancer research 60 (8), 2132-2135, 2000 | 354 | 2000 |
| Characterization of RIPK3-mediated phosphorylation of the activation loop of MLKL during necroptosis DA Rodriguez, R Weinlich, S Brown, C Guy, P Fitzgerald, CP Dillon, ... Cell Death & Differentiation 23 (1), 76-88, 2016 | 347 | 2016 |
| Role of CAR and PXR in xenobiotic sensing and metabolism YM Wang, SS Ong, SC Chai, T Chen Expert opinion on drug metabolism & toxicology 8 (7), 803-817, 2012 | 263 | 2012 |
| BOK is a non-canonical BCL-2 family effector of apoptosis regulated by ER-associated degradation F Llambi, YM Wang, B Victor, M Yang, DM Schneider, S Gingras, ... Cell 165 (2), 421-433, 2016 | 249 | 2016 |
| A2B adenosine and P2Y2 receptors stimulate mitogen-activated protein kinase in human embryonic kidney-293 cells: cross-talk between cyclic AMP and protein kinase C pathways Z Gao, T Chen, MJ Weber, J Linden Journal of Biological Chemistry 274 (9), 5972-5980, 1999 | 236 | 1999 |
| Efficacy of retinoids in IKZF1-mutated BCR-ABL1 acute lymphoblastic leukemia ML Churchman, J Low, C Qu, EM Paietta, LH Kasper, Y Chang, ... Cancer cell 28 (3), 343-356, 2015 | 188 | 2015 |
| Evaluation of 170 xenobiotics as transactivators of human pregnane X receptor (hPXR) and correlation to known CYP3A4 drug interactions M Sinz, S Kim, Z Zhu, T Chen, M Anthony, K Dickinson, AD Rodrigues Current drug metabolism 7 (4), 375-388, 2006 | 182 | 2006 |
| Nuclear receptor drug discovery T Chen Current opinion in chemical biology 12 (4), 418-426, 2008 | 145 | 2008 |
| PXR: more than just a master xenobiotic receptor PO Oladimeji, T Chen Molecular pharmacology 93 (2), 119-127, 2018 | 131 | 2018 |
| Oncogenic role and therapeutic targeting of ABL-class and JAK-STAT activating kinase alterations in Ph-like ALL KG Roberts, YL Yang, D Payne-Turner, W Lin, JK Files, K Dickerson, Z Gu, ... Blood advances 1 (20), 1657-1671, 2017 | 131 | 2017 |
| Elevation of cyclic adenosine 3′, 5′-monophosphate potentiates activation of mitogen-activated protein kinase by growth factors in LNCaP prostate cancer cells T Chen, RW Cho, PJS Stork, MJ Weber Cancer Research 59 (1), 213-218, 1999 | 131 | 1999 |
| A phosphotyrosine switch regulates organic cation transporters JA Sprowl, SS Ong, AA Gibson, S Hu, G Du, W Lin, L Li, S Bharill, ... Nature communications 7 (1), 10880, 2016 | 125 | 2016 |
| Targeting xenobiotic receptors PXR and CAR in human diseases M Banerjee, D Robbins, T Chen Drug discovery today 20 (5), 618-628, 2015 | 122 | 2015 |
| Cyclin-dependent kinase 2 negatively regulates human pregnane X receptor-mediated CYP3A4 gene expression in HepG2 liver carcinoma cells W Lin, J Wu, H Dong, D Bouck, FY Zeng, T Chen Journal of biological chemistry 283 (45), 30650-30657, 2008 | 115 | 2008 |
| Interleukin (IL)-4 indirectly suppresses IL-2 production by human T lymphocytes via peroxisome proliferator-activated receptor γ activated by macrophage-derived 12/15 … XY Yang, LH Wang, K Mihalic, W Xiao, T Chen, P Li, LM Wahl, WL Farrar Journal of Biological Chemistry 277 (6), 3973-3978, 2002 | 101 | 2002 |
| Small-molecule modulators of PXR and CAR SC Chai, MT Cherian, YM Wang, T Chen Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1859 (9 …, 2016 | 100 | 2016 |
| Mitigation of acute kidney injury by cell-cycle inhibitors that suppress both CDK4/6 and OCT2 functions N Pabla, AA Gibson, M Buege, SS Ong, L Li, S Hu, G Du, JA Sprowl, ... Proceedings of the National Academy of Sciences 112 (16), 5231-5236, 2015 | 99 | 2015 |
| Overcoming drug resistance by regulating nuclear receptors T Chen Advanced drug delivery reviews 62 (13), 1257-1264, 2010 | 97 | 2010 |
| SPA70 is a potent antagonist of human pregnane X receptor W Lin, YM Wang, SC Chai, L Lv, J Zheng, J Wu, Q Zhang, YD Wang, ... Nature communications 8 (1), 741, 2017 | 95 | 2017 |
