Stem cell gene expression programs influence clinical outcome in human leukemia K Eppert, K Takenaka, ER Lechman, L Waldron, B Nilsson, P Van Galen, ... Nature medicine 17 (9), 1086-1093, 2011 | 1201 | 2011 |
Variable clonal repopulation dynamics influence chemotherapy response in colorectal cancer A Kreso, CA O'Brien, P Van Galen, OI Gan, F Notta, AMK Brown, K Ng, ... Science 339 (6119), 543-548, 2013 | 874 | 2013 |
Single-cell RNA-seq reveals AML hierarchies relevant to disease progression and immunity P van Galen, V Hovestadt, MH Wadsworth II, TK Hughes, GK Griffin, ... Cell 176 (6), 1265-1281. e24, 2019 | 858 | 2019 |
Developmental and oncogenic programs in H3K27M gliomas dissected by single-cell RNA-seq MG Filbin, I Tirosh, V Hovestadt, MKL Shaw, LE Escalante, ... Science 360 (6386), 331-335, 2018 | 605 | 2018 |
Self-renewal as a therapeutic target in human colorectal cancer A Kreso, P Van Galen, NM Pedley, E Lima-Fernandes, C Frelin, T Davis, ... Nature medicine 20 (1), 29-36, 2014 | 555 | 2014 |
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance BB Liau, C Sievers, LK Donohue, SM Gillespie, WA Flavahan, TE Miller, ... Cell Stem Cell 20 (2), 233-246. e7, 2017 | 516 | 2017 |
The unfolded protein response governs integrity of the haematopoietic stem-cell pool during stress P van Galen, A Kreso, N Mbong, DG Kent, T Fitzmaurice, JE Chambers, ... Nature 510 (7504), 268-272, 2014 | 376 | 2014 |
miR-126 regulates distinct self-renewal outcomes in normal and malignant hematopoietic stem cells ER Lechman, B Gentner, SWK Ng, EM Schoof, P van Galen, JA Kennedy, ... Cancer cell 29 (2), 214-228, 2016 | 295 | 2016 |
Dual targeting of oncogenic activation and inflammatory signaling increases therapeutic efficacy in myeloproliferative neoplasms M Kleppe, R Koche, L Zou, P van Galen, CE Hill, L Dong, S De Groote, ... Cancer cell 33 (1), 29-43. e7, 2018 | 294 | 2018 |
Attenuation of miR-126 activity expands HSC in vivo without exhaustion ER Lechman, B Gentner, P van Galen, A Giustacchini, M Saini, ... Cell stem cell 11 (6), 799-811, 2012 | 238 | 2012 |
A cellular hierarchy framework for understanding heterogeneity and predicting drug response in acute myeloid leukemia AGX Zeng, S Bansal, L Jin, A Mitchell, WC Chen, HA Abbas, ... Nature medicine 28 (6), 1212-1223, 2022 | 178 | 2022 |
Association of clonal hematopoiesis with chronic obstructive pulmonary disease PG Miller, D Qiao, J Rojas-Quintero, MC Honigberg, AS Sperling, ... Blood, The Journal of the American Society of Hematology 139 (3), 357-368, 2022 | 161 | 2022 |
A multiplexed system for quantitative comparisons of chromatin landscapes P van Galen, AD Viny, O Ram, RJH Ryan, MJ Cotton, L Donohue, ... Molecular cell 61 (1), 170-180, 2016 | 135 | 2016 |
Integrated stress response activity marks stem cells in normal hematopoiesis and leukemia P van Galen, N Mbong, A Kreso, EM Schoof, E Wagenblast, SWK Ng, ... Cell reports 25 (5), 1109-1117. e5, 2018 | 121 | 2018 |
EHMT1 and EHMT2 inhibition induces fetal hemoglobin expression A Renneville, P Van Galen, MC Canver, M McConkey, JM Krill-Burger, ... Blood, The Journal of the American Society of Hematology 126 (16), 1930-1939, 2015 | 118 | 2015 |
Mitochondrial variant enrichment from high-throughput single-cell RNA sequencing resolves clonal populations TE Miller, CA Lareau, JA Verga, EAK DePasquale, V Liu, D Ssozi, ... Nature biotechnology 40 (7), 1030-1034, 2022 | 97 | 2022 |
Reduced lymphoid lineage priming promotes human hematopoietic stem cell expansion P van Galen, A Kreso, E Wienholds, E Laurenti, K Eppert, ER Lechman, ... Cell stem cell 14 (1), 94-106, 2014 | 94 | 2014 |
Single-cell lineage analysis reveals genetic and epigenetic interplay in glioblastoma drug resistance CE Eyler, H Matsunaga, V Hovestadt, SJ Vantine, P van Galen, ... Genome biology 21, 1-21, 2020 | 78 | 2020 |
Chromatin accessibility promotes hematopoietic and leukemia stem cell activity L Cabal-Hierro, P van Galen, MA Prado, KJ Higby, K Togami, CT Mowery, ... Nature communications 11 (1), 1406, 2020 | 61 | 2020 |
Deciphering cell states and genealogies of human haematopoiesis C Weng, F Yu, D Yang, M Poeschla, LA Liggett, MG Jones, X Qiu, ... Nature 627 (8003), 389-398, 2024 | 40 | 2024 |