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Cheryl Arrowsmith
Cheryl Arrowsmith
Senior Scientist, Princess Margaret Cancer Centre & Professor of Medical Biophysics, University of Toronto
Verified email at uhnres.utoronto.ca
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Cited by
Cited by
Year
Histone recognition and large-scale structural analysis of the human bromodomain family
P Filippakopoulos, S Picaud, M Mangos, T Keates, JP Lambert, ...
Cell 149 (1), 214-231, 2012
16322012
Epigenetic protein families: a new frontier for drug discovery
CH Arrowsmith, C Bountra, PV Fish, K Lee, M Schapira
Nature reviews Drug discovery 11 (5), 384-400, 2012
15142012
Protein production and purification
Architecture et Fonction des MacromolÚcules Biologiques Vincentelli Renaud 4 ...
Nature methods 5 (2), 135-146, 2008
9662008
Consistent blind protein structure generation from NMR chemical shift data
Y Shen, O Lange, F Delaglio, P Rossi, JM Aramini, G Liu, A Eletsky, Y Wu, ...
Proceedings of the National Academy of Sciences 105 (12), 4685-4690, 2008
8962008
The promise and peril of chemical probes
CH Arrowsmith, JE Audia, C Austin, J Baell, J Bennett, J Blagg, C Bountra, ...
Nature chemical biology 11 (8), 536-541, 2015
8032015
Chemical screening methods to identify ligands that promote protein stability, protein crystallization, and structure determination
M Vedadi, FH Niesen, A Allali-Hassani, OY Fedorov, PJ Finerty Jr, ...
Proceedings of the National Academy of Sciences 103 (43), 15835-15840, 2006
7032006
Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation
DB Yap, J Chu, T Berg, M Schapira, SWG Cheng, A Moradian, RD Morin, ...
Blood, The Journal of the American Society of Hematology 117 (8), 2451-2459, 2011
6772011
Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell–and patient-derived tumor organoids
L Huang, A Holtzinger, I Jagan, M BeGora, I Lohse, N Ngai, C Nostro, ...
Nature medicine 21 (11), 1364-1371, 2015
6702015
A suite of triple resonance NMR experiments for the backbone assignment of 15N, 13C, 2H labeled proteins with high sensitivity
T Yamazaki, W Lee, CH Arrowsmith, DR Muhandiram, LE Kay
Journal of the American Chemical Society 116 (26), 11655-11666, 1994
6631994
A chemical probe selectively inhibits G9a and GLP methyltransferase activity in cells
M Vedadi, D Barsyte-Lovejoy, F Liu, S Rival-Gervier, A Allali-Hassani, ...
Nature chemical biology 7 (8), 566-574, 2011
5312011
Self-renewal as a therapeutic target in human colorectal cancer
A Kreso, P Van Galen, NM Pedley, E Lima-Fernandes, C Frelin, T Davis, ...
Nature medicine 20 (1), 29-36, 2014
5292014
Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1
GV Avvakumov, JR Walker, S Xue, Y Li, S Duan, C Bronner, ...
Nature 455 (7214), 822-825, 2008
5162008
ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly (ADP-ribose) polymerase
H Vaziri, MD West, RC Allsopp, TS Davison, YS Wu, CH Arrowsmith, ...
The EMBO journal 16 (19), 6018-6033, 1997
5071997
An orally bioavailable chemical probe of the lysine methyltransferases EZH2 and EZH1
KD Konze, A Ma, F Li, D Barsyte-Lovejoy, T Parton, CJ MacNevin, F Liu, ...
ACS chemical biology 8 (6), 1324-1334, 2013
4672013
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
J Zhu, MA Sammons, G Donahue, Z Dou, M Vedadi, M Getlik, ...
Nature 525 (7568), 206-211, 2015
4662015
Global analysis of protein folding using massively parallel design, synthesis, and testing
GJ Rocklin, TM Chidyausiku, I Goreshnik, A Ford, S Houliston, A Lemak, ...
Science 357 (6347), 168-175, 2017
4572017
Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1: implications for EBV-mediated immortalization
V Saridakis, Y Sheng, F Sarkari, MN Holowaty, K Shire, T Nguyen, ...
Molecular cell 18 (1), 25-36, 2005
4312005
Structural proteomics of an archaeon
D Christendat, A Yee, A Dharamsi, Y Kluger, A Savchenko, JR Cort, ...
Nature structural biology 7 (10), 903-909, 2000
4132000
Fate mapping of human glioblastoma reveals an invariant stem cell hierarchy
X Lan, DJ J÷rg, FMG Cavalli, LM Richards, LV Nguyen, RJ Vanner, ...
Nature 549 (7671), 227-232, 2017
4032017
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation
SB Rothbart, K Krajewski, N Nady, W Tempel, S Xue, AI Badeaux, ...
Nature structural & molecular biology 19 (11), 1155-1160, 2012
3852012
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